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Cytotoxic effect of methanolic extracts of Fritillaria imperialis bulbs and eryngium caucasicum leaves on hepatoma and colon cancer cells

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Asian Pacific Journal of Tropical Biomedicine 2019年第8期9卷 353-358页

作者： Mostafa Kardan Zahra Yazdani Zaher Morsaljahan Mohammad Ali Ebrahimzadeh Alireza Rafiei Student Research Committee Department of ImmunologyMolecular and cell Biology Research CenterSchool of MedicineMazandaran University of Medical SciencesSariIran Department of Immunology School of MedicineMazandaran University of Medical SciencesSariIran Pharmaceutical Sciences Research Center Department of Medicinal ChemistryFaculty of PharmacyMazandaran University of Medical SciencesSariIran

Objective: To evaluate antitumor activities of Fritillaria imperialis and eryngium caucasicum methanolic extracts on human hepatoma (HepG2) and colon cancer (HCT116) cell lines in comparison to human foreskin fibroblasts as the normal cells. Methods: Methanolic extracts of Fritillaria imperialis and eryngium caucasicum were prepared by the maceration method. The effect of the extracts at various concentrations (100, 200, 400, 600, and 800 μg/mL) on cell survival was evaluated using the MTT method. Besides, fluorescence staining was used to evaluate death patterns of the cells. Results: MTT assay showed that Fritillaria imperialis significantly decreased the viability of all cell lines after 24 and 48 hours of treatments. However, eryngium caucasicum extract did not show any significant cytotoxicity effect on the cell lines. Fluorescence staining revealed that Fritillaria imperialis induced apoptosis of HCT116 cells at 550 μg/mL. Conclusions: Fritillaria imperialis extract has antiproliferative and cytotoxic effects on HCT116 and HepG2 cancer cells and therefore, may serve as an anticancer agent.

关键词： Fritillaria imperialis eryngium caucasicum Cytotoxity Colon cancer Hepatoma cancer

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Ethnobotanical and traditional uses, phytochemical constituents and biological activities of eryngium species growing in Iran

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Traditional Medicine Research 2019年第3期4卷 148-159页

作者： Masoumeh Ghajarieh Sepanlou Mehran Mirabzadeh Ardakani Mannan Hajimahmoodi Sima Sadrai Gholam-Reza Amin Naficeh Sadeghi Seyedeh Nargess Sadati Lamardi Department of Traditional Pharmacy School of Persian Medicine Tehran University of Medical Sciences Tehran Iran. Drug and Food Control Department Faculty of Pharmacy Tehran University of Medical Sciences Tehran Iran. Persian Medicine and Pharmacy Research Center Tehran University of Medical Sciences Tehran Iran. Pharmaceutical Department Faculty of Pharmacy Tehran University of Medical Sciences Tehran Iran. Pharmacognosy Department Faculty of Pharmacy Tehran University of Medical Sciences Tehran Iran.

Objective: eryngium with the 274 accepted species, is the largest genus of Apiaceae family which are distributed all over the world and have been used in traditional remedies to manage various ailments in different nations. Ten species of eryngium have been identified in Iran including E. caeruleum M.B.(syn: E. caucasicum Trautv.), E. creticum Lam., E. bungei Boiss., E. billardieri F. Delaroche.(syn: E. kotschyi Boiss.), E. glomeratum Lam.(syn: E. parviflorum Sm.), E. bornumulleri Nab., E. pyramidale Boiss.& Husson., E. noeanum Boiss., E. wanaturi Woron.(syn: E. woronowii Bordz.), and E. thyrsoideum Boiss. The aim of the present research is to review pharmacological activity, and phytochemical constituents as well as ethnobotany and traditional uses of Iranian species of eryngium. Materials and methods: Electronic databases including PubMed, Scopus, Science Direct (ISI Web of Knowledge) and Embase library were comprehensively searched for research on eryngium. The search period was from 1966 to October 2018. The related articles were selected according to the inclusion and exclusion criterias in our study. Results: A total of 57 papers were enrolled in analyses. The findings showed that Iranian species of eryngium, had a noticeable diverse of traditional medicinal uses and also broad range of pharmacological activities as well as various phytochemical compounds. Some remarkable biological and pharmacological activities of these species have been demonstrated in present scientific studies, including antimicrobial, cytotoxic and anticancer, anti-inflammatory, analgesic and antinociceptive activities as well as antioxidant, antidiabetic, anti-snake and anti-scorpion venom effects. Conclusion: Iranian eryngium species have enormous potential for prospective preparation of herbal medicinal products and are good candidates for discovering new drugs.

关键词： eryngium Iranian species Pharmacological activities Phytochemical compositions Traditional and ethnopharmacological uses

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Phenolic composition and antioxidant properties of eryngium maritimum (sea holly)

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Journal of Coastal Life Medicine 2017年第5期5卷 212-215页

作者： Ilhem Rjeibi Anouar Ben Saad Sana Ncib Sami Souid Research Unit of Macromolecular Biochemistry and Genetic Faculty of Sciences of GafsaGafsa2112Tunisia Common Services Unit for Research Faculty of Sciences of GafsaGafsa2112Tunisia

Objective: To examine the antioxidant potential of Tunisian eryngium maritimum (E. maritimum) leaf, root and stems extracts, as well as their phenolic compositions. Methods: The antioxidant activity of different extracts was assessed using DPPH free radical and hydrogen peroxide scavenging assays. Phenolic profiles were determined by means of liquid chromatography (HPLC-DAD). Results: All plant parts were a rich source of phenolics. Polyphenols and flavonoids were present in leaf extracts. E. maritimum leaf extracts displayed the strongest H2O2 scavenging activity (IC50 = 76.83 μg/mL) and the highest DPPH scavenging activity value (IC50 = 47.87 μg/mL) compared to other extracts. Good relationships were observed between antioxidant activities and the total phenolic and flavonoid contents. Nine bioactive compounds were detected in E. maritimum extracts. Conclusions: Our results provided evidence that E. maritimum could be an interesting source of natural antioxidant that can be used to treat divers diseases.

关键词： eryngium maritimum Phenolic compositions Antioxidant activity

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