检索结果-南通市图书馆

Potential of phloroglucinol to improve erectile dysfunction associated with streptozotocin-induced diabetes in rats

Journal of Integrative Medicine 2019年第4期17卷 282-287页

作者： Syed Kashif Rema Razdan Ramanaiah Illuri Department of Pharmacology Al-Ameen College of Pharmacy Bengaluru Karnataka 560027 India PG and Research Centre in Biotechnology MGR College Hosur Tamil Nadu 635109 India

Objective: Diabetes is a common metabolic disease with several complications in its patients. Often, people living with diabetes develop erectile dysfunction (ED). The primary aim of this work was to investigate the effect of phloroglucinol in diabetes-induced ED in rats. Methods: Male Wistar rats were given 52 mg/kg of streptozotocin, by intraperitoneal injection, to induce diabetes and ED. Subsequently, animals were grouped into three groups: group 1, diabetic control;group 2, low-dose phloroglucinol (150 mg/kg body weight);and group 3, high-dose phloroglucinol (250 mg/kg body weight). A group of six normal rats served as a normal control. The rats were treated with phloroglucinol for six weeks and then were assessed for treatment effects. Sexual behavior, glycosylated hemoglobin Ale (HbAlc) values, serum testosterone, serum nitric oxide (NO), blood pressure and sperm count were measured after the end of treatment. Results: After a 6-week treatment period, the high dose of phloroglucinol significantly decreased HbAlc values in diabetic rats. Rats treated with phloroglucinol had increased serum testosterone, NO and sperm count. Animals treated with 250 mg/kg phloroglucinol performed similar to normal rats in the sexual behavioral study, suggesting the reversal of complications of ED. Conversely, a decrease in the blood pressure in treated groups was observed. Conclusion: The results highlight the protective effect of phloroglucinol in diabetes-induced ED in rats warranting further studies.

关键词： Diabetes Streptozotocin erectile dysfunction Phloroglucinol Glycated hemoglobin A

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Consecutive nightly measurements are needed for accurate evaluation of nocturnal erectile capacity when the first-night laboratory recording is abnormal

引用

Asian Journal of Andrology 2020年第1期22卷 94-99页

作者： Zi-Jun Zou Shi-Tao Chen Gong-Chao Ma Yu-Fen Lai Xiao-Jian Yang Jia-Rong Feng Zhi-Jun Zang Tao Qi Bo Wang Lei Ye Yan Zhang Department of Infertility and Sexual Medicine The Third Affiliated HospitalSun Yat-sen UniversityGuangzhou 510630China

Multiple measurements of nocturnal penile tumescence and rigidity(NPTR)are widely accepted as a method to differentiate psychogenic erectile dysfunction(ED)from organic ED.However,direct evidence remains limited regarding the first-night effect on NPTR measurement using the RigiScan.Here,we evaluated the first-night effect on the results of NPTR measurement to validate the necessity of NPTR measurement for two consecutive nights,particularly when abnormal first-night measurements are recorded in a laboratory setting.We retrospectively reviewed 105 patients with a complaint of ED,who underwent NPTR measurement using the RigiScan in the Department of Infertility and Sexual Medicine,the Third Affiliated Hospital of Sun Yat-sen University(Guangzhou,China),for two consecutive nights,during the period from November 2015 to May 2016.NPTR parameters were collected and analyzed.We found that more effective nocturnal erections were detected during the second night than during the first night(Perectile capacity,especially when the first-night record is abnormal in a laboratory setting.

关键词： erectile dysfunction nocturnal penile tumescence and rigidity penis RigiScan

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Novel noninvasive quantification of penile corpus caver no sum lesions in hyperlipidemia-induced erectile dysfunction in rabbits by two-dimensional shear-wave elastography

引用

Asian Journal of Andrology 2019年第2期21卷 143-149页

作者： Jian-Lin Hu Hui-Xing Chen Hui-Rong Chen Yu Wu Xiao-Wen Sun Zheng Li Jin-Fang Xing Department of Reproductive Medicine Shanghai General HospitalShanghai Jiao Tong UniversitySchool of MedicineShanghai 201620China Department of Andrology Center for Men's HealthUrologic Medical CenterShanghai General HospitalShanghai Jiao Tong UniversitySchool of MedicineShanghai 200080China Department of Urology Shanghai General HospitalShanghai Jiao Tong UniversitySchool of MedicineShanghai 201620China Department of Medical Ultrasound Shanghai General HospitalShanghai Jiao Tong UniversitySchool of MedicineShanghai 200080China

Structural alterations in fibroelastic compone nts of the penile corpus caver no usum(CC)may impair its compliance,resulting in venous leakage and erectile dysfunction(ED).Our study evaluated the effectiveness of noninvasive two-dimensional shear-wave elastography(2-D SWE)in quantifying penile CC lesions in rabbits with hyperlipidemia-induced ED.A total of 12 New Zealand white rabbits were randomly divided into two groups.Six were fed a high-cholesterol diet containing 2%cholesterol and 8.5%lard for 10 weeks and the other six were fed normal diet as controls.We measured the shear-wave elastic quantitative(SWQ)value of penile CC by 2-D SWE.erectile function was inv estigated by intracavernous injecti on of pa pa ver i ne,and immunohistochemical(IHC)stain inga nd the wester n blot analysis to determine the penile CC lesions.After 10 weeks,the SWQ values obtained from penile CC were remarkably higher in the high-cholesterol-fed compared with the control group,and the AICP(ICP plateau minus ICP baseline)/MAP(ICP:intracavernous pressure,MAP:mean arterial pressure)was markedly decreased.The IHC staining and western blot revealed extracellular matrix(ECM)accumulation in penile cavernous tissues,and the smooth muscle cell(SMC)phenotypic transition was affected,as indicated by reduced alpha-smooth muscle actin and calponinexpression and increased phospho-myosin light chain?。(p-MLC20)/MLC20 and osteopontin expression.Hyperlipidemia resulted in ECM accumulation accompanied with SMC phenotypic transition in penile CC and impaired the erectile function eventually.These might,in turn,lead to variations in the SWQ values.It suggests that 2-D SWE may be a novel,noninvasive and effective approach that distinguishes penile CC lesions secondary to hyperlipidemia from normal.

关键词： corpus cavernosum erectile dysfunction extracellular matrix accumulation phenotypic transition shear-wave elastography smooth muscle cells

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

G protein-coupled receptor kinase 2 inhibition improves erectile function through amelioration of endothelial dysfunction and oxidative stress in a rat model of type 2 diabetes

引用

Asian Journal of Andrology 2019年第1期21卷 74-79页

作者： Zhi-Hua Wan Yuan-Jie Zhang Lin Chen Yong-Lian Guo Guo-Hao Li Ding Wu Yong Wang Department of Urology The Central Hospital of WuhanTongll Medical CollegeHuazhong University of Science and TechnologyWuhan 430014China

Type 2 diabetes mellitus (T2DM)is a common cause of erectile dysfunction (ED).It has been demonstrated that G protein-coupled receptor kinase 2 (GRK2)overexpression contributes to diabetic endothelial dysfunction and oxidative stress,which also underlies ED in T2DM.We hypothesized that GRK2 overexpressed and attenuated endothelial function of the cavernosal tissue in a rat model of T2DM.T2DM rats were established by feeding with a high-fat diet (HFD)for 2 weeks and then administering two intraperitoneal (IP) injections of a low dose of streptozotocin (STZ),followed by continuous feeding with a HFD for 6 weeks.GRK2 was inhibited by IP injection of paroxetine,a selective GRK2 inhibitor,after STZ injection.Insulin challenge tests,intracavernous pressure (ICP), GRK2 expression,the protein kinase B (Akt)/endothelial nitric oxide synthase (eNOS)pathway,nicotinamide adenine dinucleotide phosphate (NADPH)oxidase subunit gp91phox,nitric oxide (NO),reactive oxygen species (ROS)production,and apoptosis in cavernosal tissue were examined.Less response to insulin injection was observed in T2DM rats 2 weeks after HFD.Markedly increased GRK2 expression,along with impaired Akt/eNOS pathway,reduced NO production,increased gp91phox expression and ROS generation,increased apoptosis and impaired erectile function were found in T2DM rats.inhibition of GRK2 with paroxetine ameliorated Akt/eNOS signaling,restored NO production,downregulated NADPH oxidase,subsequently inhibited ROS generation and apoptosis,and ultimately preserved erectile function.These results indicated that GRK2 upregulation may be an important mechanism underlying T2DM ED,and GRK2 inhibition may be a potential therapeutic strategy for T2DM ED.

关键词： endothelial dysfunction erectile dysfunction G protein-coupled receptor kinase 2 oxidative stress type 2 diabetes mellitus

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Losartan improves erectile function through suppression of corporal apoptosis and oxidative stress in rats with cavernous nerve injury

引用

Asian Journal of Andrology 2019年第5期21卷 452-459页

作者： Yi Wang Xiang-Hu Meng Qi-Jie Zhang Ya-Min Wang Chen Chen Yi-Chun Wang Xiang Zhou Cheng-Jian Ji Ning-Hong Song Department of Urology The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China

This study aimed to investigate the functional and morphological changes in the corpus cavernosum after cavernous nerve(CN)injury or neurectomy and then reveal whether treatment with the angiotensin II Type 1 receptor antagonist losartan would improve erectile function as well as its potential mechanisms.A total of 48 10-week-old Sprague-Dawley male rats,weighing 300-350 g,were randomly divided into the following four groups(n=12 per group):sham operation(Sham)group,bilateral cavernous nerve injury(BOND group,losartaretreated BCNI(BCNI+Losartan)group,and bilateral cavernous neurectomy(Neurectomy)group.Losartan was administered once daily by oral gavage at a dose of 30 mg kg^-1 day^-1 for 4 weeks starting on the day of surgery.The BCNI and the Neurectomy groups exhibited decreases in erectile response and increases in apoptosis and oxidative stress,compared with the Sham group.Treatment with losartan could have a modest effect on erectile function and significantly prevent corporal apoptosis and oxidative stress?The phospho-B-cell lymphoma 2(Bcl-2)-associated death promoter(p-Bad)/Bad and phospho-the protein kinase B(p-AKT)/AKT ratios were substantially lower,while the Bcl-2-associated X protein(Bax)/Bcl-2 ratio,nuclear factor erythroid 2-related factor 2(Nrf2)/Kelch-like ECH-associated protein 1(Keap-1),transforming growth factor-p 1(TGF-pi)and heme oxygenase-1(HO-1)levels,and caspase-3 activity were higher in the BCNI and Neurectomy groups than in the Sham group.After 4 weeks of daily administration with losartan,these expression levels were remarkably attenuated compared with the BCNI group.Taken together,our results suggested that early administration of losartan after CN injury could slightly improve erectile function and significantly reduce corporal apoptosis and oxidative stress by inhibiting the Akt/Bad/Bax/caspase-3 and Nrf2/Keap-1 pathways.

关键词： angiotensin II apoptosis erectile dysfunction fibrosis losartan oxidative stress

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dynamic infusion cavernosometry and cavernosography for classifying venous erectile dysfunction and its significance for individual treatment

引用

Chinese Medical Journal 2019年第4期132卷 405-410页

作者： Qing-Qiang Gao Jian-Huai Chen Yun Chen Tao Song Yu-Tian Dai Department of Andrology Nanjing Drum Tower HospitalAffiliated Hospital of Nanjing University Medical SchoolNanjingJiangsu 210008China Department of Andrology Jiangsu Province Hospital of Chinese MedicineAffiLiated Hospital of Nanjing University of Chinese MedicineNanjingJiangsu 210029China.

Background: The precise pathophysiology of venous erectile dysfunction (VED) was still unclear. Dynamic infusion cavernosometry and cavernosography (DICC) was the gold standard approach for the diagnoses of VED. However, a standard operative procedure of DICC was needed and it was unclear whether DICC could show promise in accurate assessment and treatment of VED. The aim of this study was to establish an optimized operation process of DICC and evaluate the efficacy of DICC in the diagnoses and therapy of VED. Methods: One hundred and forty-seven VED patients identified by the color doppler duplex ultrasonography (CDDU) were included. Then the method of DICC was adopted to assess the severity of VED and all patients were divided into 4 groups, including (1) non-VED;(2) mild VED;(3) moderate VED and (4) severe VED. All patients received the treatment of psychotherapy. Drug therapy, the intervention embolism of corpus cavernosum and the implantation of penile prosthesis were applied if psychotherapy was ineffective for patients. The international index of erectile function (IIEF-5) scores of patients were collected and compared before and after treatment. Results: IIEF-5 score of non-VED group after psychotherapy (19.35 ± 3.59) and drug therapy (23.31 ± 0.75) was higher than that before psychotherapy (15.30 ± 2.72, t=-4.31, P 0.05). IIEF-5 score of severe VED group was increased under the treatment of implantation of penile prosthesis (23.25 ± 0.71) compared with that before treatment (8.00 ± 0.39, t= -53.25, P < 0.05)

关键词： Venous erectile dysfunction Dynamic infusion cavernosometry and cavernosography Diagnosis Treatment

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The effects of single versus combined therapy using LIM-kinase 2 inhibitor and type 5 phosphodiesterase inhibitor on erectile function in a rat model of cavernous nerve injury-induced erectile dysfunction

引用

Asian Journal of Andrology 2019年第5期21卷 493-500页

作者： Min Chui Cho Junghoon Lee Juhyun Park Sohee Oh Ji Sun Chai Hwancheol Son Jae-Seung Paick Soo Woong Kim Department of Urology Seoul National University College of MedicineSMG-SNU Boramae Medical CenterSeoul 07061Korea Department of Urology Seoul National University College of MedicineSeoul National University HospitalSeoul 03080Korea Department of Biostatistics Seoul National University College of MedicineSMG-SNU Boramae Medical CenterSeoul 07061Korea

We aimed to determine whether combination of LIM-kinase 2 inhibitor(LIMK2i)and phosphodiesterase type-5 inhibitor(PDE5i)could restore erectile function through suppressing cavernous fibrosis and improving caver nous apoptosis in a rat model of cavernous nerve crush injury(CNCI).Seventy 12-week-old Sprague-Dawley rats were equally distributed into five groups as follows:(1)sham surgery(Group S),(2)CNCI(Group I),(3)CNCI treated with daily intraperitoneal administration of 10.0 mg kg^-1 LIMK2i(Group I+L),(4)daily oral administration of 20.0 mg kg-1 udenafil,PDE5i(Group I+U),and(5)combined administration of 10.0 mg kg^-1 LIMK2i and 20.0 mg kg^-1 udenafil(Group I+L+U).Rats in Groups I+L,I+U,and I+L+U were treated with respective regimens for 2 weeks after CNCI.At 2 weeks after surgery,erectile response was assessed using electrostimulation.Penile tissues were processed for histological studies and western blot.Group I showed lower intracavernous pressure(ICP)/mean arterial pressure(MAP),lower area under the curve(AUC)/MAP,decreased immunohistochemical staining for alpha-smooth muscle(SM)actin,higher apoptotic index,lower SM/collagen ratio,increased phospho-LIMK2-positive fibroblasts,decreased protein kinase B/endothelial nitric oxide synthase(Akt/eNOS)phosphorylation,increased LIMK2/cofilin phosphorylation,and increased protein expression of fibronectin,compared to Group S.In all three treatment groups,erectile responses,protein expression of fibronectin,and SM/collagen ratio were improved.Group I+L+U showed greater improvement in erectile response than Group I+L.SM content and apoptotic index in Groups I+U and I+L+U were improved compared to those in Group I.However,Group I+L did not show a significant improvement in SM content or apoptotic index.The number of phospho-LIMK2-positive fibroblasts was normalized in Groups I+L and I+L+U,but not in Group I+U.Akt/eNOS phosphorylation was improved in Groups I+U and I+L+U,but not in Group I+L.LIMK2/cofilin phosphorylation was improved in Groups I+L and I+L+U,but not in Group

关键词： apoptosis erectile dysfunction fibrosis LIM kinase phosphodiesterase

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Adipose-derived stem cells modified by BDNF gene rescue erectile dysfunction after cavernous nerve injury

引用

Neural Regeneration Research 2020年第1期15卷 120-127页

作者： Mei Yang Jiang-Yang Sun Cheng-Cheng Ying Yong Wang Yong-Lian Guo Department of Endocrinology Tongren Hospital of Wuhan University(Wuhan Third Hospital)WuhanHubei ProvinceChina Department of Hepatobiliary Surgery The Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Urology The Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Cavernous nerve injury is the main cause of erectile dysfunction following radical prostatectomy.The recovery of erectile function following radical prostatectomy remains challenging.Our previous studies found that injecting adipose-derived stem cells(ADSCs)into the cavernosa could repair the damaged cavernous nerves,but the erectile function of the treated rats could not be restored to a normal level.We evaluated the efficacy of ADSCs infected with a lentiviral vector encoding rat brain-derived neurotrophic factor(lenti-rBDNF)in a rat model of cavernous nerve injury.The rats were equally and randomly divided into four groups.In the control group,bilateral cavernous nerves were isolated but not injured.In the bilateral cavernous nerve injury group,bilateral cavernous nerves were isolated and injured with a hemostat clamp for 2 minutes.In the ADSCGFP and ADSCrBDNF groups,after injury with a hemostat clamp for 2 minutes,rats were injected with ADSCs infected with lenti-GFP(1×106 in 20μL)and lenti-rBDNF(1×106 in 20μL),respectively.erectile function was assessed 4 weeks after injury by measuring intracavernosal pressures.Then,penile tissues were collected for histological detection and western blot assay.Results demonstrated that compared with the bilateral cavernous nerve injury group,erectile function was significantly recovered in the ADSCGFP and ADSCrBDNF groups,and to a greater degree in the ADSCrBDNF group.Neuronal nitric oxide synthase content in the dorsal nerves and the ratio of smooth muscle/collagen were significantly higher in the ADSCrBDNF and ADSCGFP groups than in the bilateral cavernous nerve injury group.Neuronal nitric oxide synthase expression was obviously higher in the ADSCrBDNF group than in the ADSCGFP group.These findings confirm that intracavernous injection with ADSCs infected with lenti-rBDNF can effectively improve erectile dysfunction caused by cavernous nerve injury.This study was approved by the Medical Animal Care and Welfare Committee of Wuhan University,China(approval No.2017-1638)on

关键词： adipose-derived stem cells brain-derived neurotrophic factor cavernous nerve injury erectile dysfunction infection intracavernous injection lentiviral vector neuronal nitric oxide synthase radical prostatectomy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Human tissue kallikrein-1 protects against the development of erectile dysfunction in a rat model of hyperhomocysteinemia

引用

Asian Journal of Andrology 2019年第5期21卷 508-515页

作者： Kai Cui Yang Luan Zhe Tang Chuan-Chang Li Tao Wang Shao-Gang Wang Zhong Chen Ji-Hong Liu Department of Urology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Institute of Urology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

The aim of this study was to investigate the mechanism by which a diet inducing high hyperhomocysteinemia(HHcy)leads to the deterioration of erectile function in rats and whether this is inhibited by expression of the human tissue kallikrein-1(hKLKl)gene.We established a rat model of HHcy by feeding methionine(Met)-rich diets to male Sprague-Dawley(SD)rats.Male wild-type SD rats(WTRs)and transgenic rats harboring the hKLKl gene(TGRs)were fed a normal diet until 10 weeks of age.Then,30 WTRs were randomly divided into three groups as follows:the control(n=10)group,the low-dose(4%Met,n=10)group,and the high-dose(7%Met,n=10)group.Another 10 age-matched TGRs were fed the high-dose diet and designated as the TGR+7%Met group.After 30 days,in all four groups,erectile function was measured and penile tissues were harvested to determine oxidative stress,endothelial cell content,and penis fibrosis.Compared with the 7%Met group,the TGR+7%Met group showed diminished HHcy-induced erectile dysfunction(ED),indicating the improvement caused by hKLKl.Regarding corpus cavernosum endothelial cells,hKLKl preserved endothelial cell-cell junctions and endothelial cell content,and activated protein kinase B/endothelial nitric oxide synthase(Akt/eNOS)signaling.Fibrosis assessment indicated that hKLKl preserved normal penis structure by inhibiting apoptosis in the corpus cavernosum smooth muscle cells.Taken together,these findings showed that oxidative stress,impaired corpus cavernosum endothelial cells,and severe penis fibrosis were involved in the in duction of ED by HHcy in rats,whereas hKLKl preserved erectile function by inhibiting these pathophysiological changes.

关键词： endothelial cell erectile function fibrosis human tissue kallikrein-1 hyperhomocysteinemia oxidative stress

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Association of erectile dysfunction with depression in patients with chronic viral hepatitis

引用

World Journal of Gastroenterology 2015年第18期21卷 5641-5646页

作者： Bong Oh Ma Sang Goon Shim Hae Jin Yang Department of Medicine Samsung Changwon Hospital Sungkyunkwan University School of Medicine Changwon-si 630-723 South Korea

AIM: To investigate the prevalence of erectile dysfunction(ED) and its association with depression in patients with chronic viral hepatitis.METHODS: This single center cross-sectional study was conducted from August 2013 through January 2014. All outpatients with chronic viral hepatitis in our liver clinic between 18 and 80 years of age were considered eligible for this study. The exclusion criteria included well-established causes of ED, such as diabetes, hypertension, hyperlipidemia, alcohol abuse, liver cirrhosis, ischemic heart disease, renal disease, neurologic disease, and malignancy. We also excluded the patients who had incompletely answered the questionnaires. ED was assessed using the validated Korean version of the International Index of erectile Function(IIEF-5) scale. The Korean version of the self-administered Beck Depression Inventory(BDI) scale was used to assess depression in the patients. Demographic and medical data were obtained from the patients' medical records. Current or past history of psychiatric diagnosis and drug history including the use of an antiviral agent and an antidepressant were also recorded. RESULTS: A total of 727 patients met the initial eligibility criteria. Six hundred seventeen patients were excluded because their medical records contained one or more of the previously determined exclusion criteria. The remaining 110 patients were assessed based on the BDI and IIEF-5 questionnaires. Based on the IIEF-5 scale, the prevalence of ED among patients with chronic viral hepatitis was 40%. Compared with the non-ED group, patients in the ED group were older. The proportion of patients in the ED group who had a job or who were na?ve peg-interferon users was lower than that in patients in the non-ED group. Patients with ED had significantly lower scores on the IIEF-5 scale than patients without ED(11.75 ± 4.88 vs 21.33 ± 1.86, P = 0.000). Patients with ED rated significantly higher scores on the BDI scale compared with patients without ED(12.59 ± 7.08 vs 5.30 ± 4.00, P = 0.000). Al

关键词： Beck depression inventory Chronic viral hepatitis Depression erectile dysfunction International Index of erectile Function-5

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：