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Recurrence of infectious mononucleosis in adults after remission for 3 years:A case report

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World Journal of Clinical Cases 2022年第12期10卷 3951-3958页

作者： Xin-Yue Zhang Qi-Bei Teng Department of Traditional Chinese Medicine The Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center For Child HealthHangzhou 310052Zhejiang ProvinceChina Department of Hematology Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016Zhejiang ProvinceChina

BACKGROUND Infectious mononucleosis(IM)is a disease caused by epstein–barr virus(EBV).EBV infection is common in children;however,it can cause IM in *** on recurrence of IM in adults after remission are *** SUMMARY We report a 28-year-old man who presented with IM-like symptoms with mild liver damage after initial remission of IM for 3 *** was first diagnosed with IM and treated in ***-up tests in 2016 and 2017 did not show any *** November 2018,he presented with swelling of the *** was misdiagnosed with acute suppurative tonsillitis and treated for 5 *** signs of improvement were *** was readmitted with recurrent fever,pharyngalgia,fatigue,and systemic muscle *** revealed enlargement of the tonsils and cervical lymph *** tests revealed elevated transaminase ***-EBV test was positive,indicating virus *** recurrence was confirmed on the basis of laboratory tests and clinical *** was treated with antiviral,anti-infective,and hepatoprotective drugs and vitamin *** condition improved and no abnormalities were observed during *** Recurrence of IM after remission is possible in adults;therefore,long-term followup and monitoring are essential.

关键词： Adults epstein–barr virus Infectious mononucleosis Liver damage Recurrence Case report

CK5/6-positive,P63-positive lymphoepithelioma-like hepatocellular carcinoma:A case report and literature review

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World Journal of Clinical Cases 2023年第19期11卷 4640-4647页

作者： Hong-Tao Tang Wei Lin Wei-Qiao Zhang Jun-Lin Qian Kai Li Kun He Graduate School of Guangdong Medical University Zhanjiang 524002Guangdong ProvinceChina Department of Hepatobiliary Surgery Zhongshan People’s HospitalZhongshan 528400Guangdong ProvinceChina

BACKGROUND Lymphoepithelioma-like carcinoma(LELC),a rare and unique variant of liver cancer,can be divided into lymphoepithelioma-like hepatocellular carcinoma and lymphoepithelioma-like intrahepatic *** lymphocytic infiltration is its characteristic pathological *** recent years,the number of reported cases of this type has increased each *** have shown that lymphoepithelioma-like cholangiocarcinoma occurs more frequently in Asian women;LELC is associated with epstein–barr virus infection of liver cells of epithelial *** research shows that the prognosis of this tumour is *** SUMMARY A 38-year-old female patient was hospitalized after 3 mo of abdominal pain and *** had been infected with hepatitis B virus more than 10 years *** patient was hospitalized on January 21,*** resonance imaging showed a 36 mm×28 mm mass under the envelope of the left inner lobe of the *** metastasis of lymph nodes or other organs was *** left hemihepatectomy,biopsy and immunohistochemistry yielded a final diagnosis of lymphoepithelial hepatocellular *** 12 mo of outpatient follow-up and chemotherapy,no tumour metastases were found on the latest computed tomography *** Herein,the patient was treated surgically and then followed up as an outpatient for 12 *** case will further expand our overall knowledge of the diagnosis and treatment of this rare tumor.

关键词： Liver cancer Lymphoepithelioma-like carcinoma Hepatocellular carcinoma epstein–barr virus Literature review Case report

Aggressive natural killer cell leukemia with skin manifestation associated with hemophagocytic lymphohistiocytosis:A case report

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World Journal of Clinical Cases 2021年第34期9卷 10708-10714页

作者： Xiao-Huan Peng Lian-Sheng Zhang Li-Juan Li Xiao-Jia Guo Yang Liu Department of Hematology Second Hospital of Lanzhou UniversityLanzhou 730030Gansu ProvinceChina

BACKGROUND Aggressive natural killer cell leukemia(ANKL)is a rare natural killer cell neoplasm characterized by systemic infiltration of epstein–barr virus and rapidly progressive clinical *** can be accompanied with hemophagocytic lymphohistiocytosis(HLH).Here,we report a case of ANKL with rare skin lesions as an earlier manifestation,accompanied with HLH,and review the literature in terms of etiology,clinical manifestation,diagnosis and *** SUMMARY A 30-year-old woman from Northwest China presented with the clinical characteristics of jaundice,fever,erythema,splenomegaly,progressive hemocytopenia,liver failure,quantities of abnormal cells in bone marrow,and associated *** immunophenotypes of abnormal cells were positive for CD2,cCD3,CD7,CD56,CD38 and negative for sCD3,CD8 and *** diagnosis of ANKL complicated with HLH was *** the initial diagnosis and supplementary treatment,the patient received chemotherapy with VDLP regimen(vincristine,daunorubicin,L-asparaginase and prednisone).However,the patient had severe adverse reactions and complication such as severe hematochezia,neutropenia,and multiple organ dysfunction syndrome,and died a few days *** This is the first reported case of ANKL with rare skin lesions as an earlier manifestation and associated with HLH.

关键词： Aggressive natural killer cell leukemia Hemophagocytic lymphohistiocytosis Rare skin lesions epstein–barr virus Diagnosis and treatment Case report

Research Progress on Systemic Lupus Erythematosus Complicated with Infection

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国际感染病学（电子版） 2015年第2期4卷 50-54页

作者： Weisan Zhang Department of Geriatrics Tianjin Medical University General Hospital

In recent years, in treatment standardization of systemic lupus erythematosus (SLE), infections and serious complications became the leading cause of death related to this disease, exceeding those of renal involvement and lupus encephalopathy. SLE coinfection is mainly related to defects in humoral immunity and cellular immunity, SLE disease activity, and doses of hormone and immune inhibitors.

关键词： Systemic lupus erythematosus Infection Antinuclear epstein–barr virus