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Posterior pedicle screw fixation combined with local steroid injections for treating axial eosinophilic granulomas and atlantoaxial dislocation:A case report

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World Journal of Clinical Cases 2023年第20期11卷 4944-4955页

作者： Cheng-Quan Tu Zhi-Da Chen Xiao-Tao Yao Yuan-Jie Jiang Bi-Fang Zhang Bin Lin Department of Orthopedic Surgery The 909^(th)HospitalSchool of MedicineXiamen UniversityZhangzhou 363000Fujian ProvinceChina School of Medicine Xiamen UniversityXiamen 361005Fujian ProvinceChina

BACKGROUND eosinophilic granuloma(EG)is a proliferative condition that affects the cells of bone *** are no specific clinical signs or imaging manifestations in the early stages of the disease,making it simple to overlook and *** of the disease's rarity,there is presently no standardized treatment *** are few accounts of such occurrences affecting the axis among *** discovered a case of a child whose EG resulted in atlantoaxial joint dislocation and destruction of the axial *** SUMMARY After having pharyngeal discomfort for more than six months without a clear explanation,a 6-year-old boy was brought to our *** a careful evaluation,the pathology indicated a strong likelihood of an axial ***,we decided to treat the boy with posterior pedicle screw fixation and local steroid *** EGs of the upper cervical spine are quite uncommon in children,and they are exceedingly easy to overlook or *** pedicle screw fixation and local steroid injections are effective treatments for patients with axial EGs affecting the atlantoaxial junction.

关键词： eosinophilic granuloma Atlantoaxial joint dislocation Local steroid injections Children Osteopathy Posterior surgery Case report

Bone analysis using an aggregation-induced emission-active iridium complex

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Aggregate 2023年第6期4卷 110-119页

作者： Xianpeng Zhang Xinling Liu Hongwen Yu Shuang Shen Junchao Zhi Zhen GaoJingqi Xin Jiaqi Song Liang Shao Caiting Meng Feifei An Taotao Huo Shichang Liu Ye Zhang Li Xu Guanying Li Department of Biophysics School of Basic Medical SciencesHealth Science CentreXi’an Jiaotong UniversityXi’anP.R.China School of Chemistry and Chemical Engineering Guangdong Pharmaceutical UniversityZhongshanP.R.China Department of Spine Surgery Honghui HospitalXi’an Jiaotong UniversityXi’anP.R.China Active Soft Matter Group Songshan Lake Materials LaboratoryDongguanP.R.China School of Public Health Health Science CentreXi’an Jiaotong UniversityXi’anP.R.China

Fluorescent analysis of bone provides valuable insights into bone ***,conventional dyes suffer from low specificity on bone tissue,small stokes shift,short fluorescent lifetime,and aggregation-caused quenching effect,which result in low efficacy and *** this work,we design an aggregation-induced emission(AIE)-active iridium(III)complex(Ir-BP2)as a highly selective,convenient,nondestructiveness,and dual-mode staining agent for bone ***-BP2 containing phosphonate groups selectively binds to hydroxyapatites,the main component of bone matrix,and exhibits turn-on AIE phosphorescence with prolonged ***-BP2 exhibits promising biosafety and offers higher accuracy in staining calcium deposits than conventional Alizarin Red S staining assay when it is employed in real-time monitoring of osteogenesis differentiation process.A ready-to-use staining spray of Ir-BP2 is *** using fluorescent imaging and lifetime imaging,Ir-BP2 staining provides valuable insights into bone microstructure analysis,microdamage diagnosis,and bone growth state ***,Ir-BP2 is successfully applied on a human spine vertebra for diagnosing bone invasiveness of eosinophilic granuloma,validating its clinical *** work presents a powerful tool in bone analysis and will lead to new approaches for the diagnosis and treatment of bone-related diseases.

关键词： aggregation-induced emission bone analysis clinical diagnosis eosinophilic granuloma iridium complexes phosphorescent probe

A rare case of langerhans cell histiocytosis of the gastrointestinal tract

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World Journal of Gastroenterology 2012年第12期18卷 1410-1413页

作者： Uday Shankar Monika Prasad Om P Chaurasia Internal Medicine Mount Sinai School of Medicine at Queens Hospital CenterJamaicaNY 11432United States Department of Medicine University of CaliforniaIrvineCA 92697United States

Langerhans cell histiocytosis （LCH） is a group of idiopathic disorders characterized by the proliferation of specialized, bone marrow-derived langerhans cells and mature eosinophils. The clinical spectrum ranges from an acute, fulminant, disseminated disease called Letterer Siwe disease to solitary or few, indolent and chronic lesions of the bone or other organs called eosinophilic granuloma. Involvement of the gastrointestinal tract is very rare in LCH. We present the case of a 53-year-old woman referred by her primary care physician for a screening colonoscopy. A single sessile polyp, measuring 4 mm in size, was found in the rectum. Histopathological examination revealed that the lesion was relatively well circumscribed and comprised mainly a mixture of polygonal cells with moderate-to-abundant pink slightly granular cytoplasm. The nuclei within these cells had frequent grooves and were occasionally folded. Immunohistochemical staining was positive for CD la which confirmed the diagnosis of LCH. On further workup, there was no evidence of involvement of any other organ. On follow up colonoscopy one year later, there was no evidence of disease recurrence. Review of the published literature revealed that LCH presenting as solitary colonic polyp is rare. However, with the increasing rates of screening colonoscopy, more colonic polyps may be identified as LCH on histopathology. This underscores the importance of recognizing this rare condition and ensuring proper follow-up to rule out systemic disease.

关键词： Langerhans cells Histiocytosis Colonic pol-yp CD-la eosinophilic granuloma Screening Colono-scopy

eosinophilic gastroenteritis in basset hound dog

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Open Journal of Animal Sciences 2012年第2期2卷 110-112页

作者： Carlos E.Fonseca-Alves Aline G.Correa Fabiana Elias Department of Clinical Veterinary Medicine School of Veterinary Medicine and Animal ScienceSao Paulo State UniversityBotucatuBrazil Department of Veterinary Medicine Pioneer Union of Social IntegrationBrasiliaBrazil

An 1-year-old male Basset Hound dog was evaluated for chronic intermittent vomiting, hematemesis, and melena which had been ongoing for several months. The histopathologic examination revealed that all layers of the small intestine were thicker than normal. The lamina propria of the mucosa, including the villi, exhibited a prominent cellular infiltrate which consisted of numerous eosinophils and an increased numbers of plasma cells in addition to the normal lymphocytic component. The muscularis mucosa was invaded, and in some places disrupted, by eosinophils, which also infiltrated into the submucosa and muscularis propria. This report describes the pathological findings of a case of eosinophilic gastroenteritis (EG) in a dog.

关键词： eosinophilic granuloma Gastroenteritis Canine