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environmental enrichment in combination with Bifidobacterium breve HNXY26M4 intervention amplifies neuroprotective benefits in a mouse model of Alzheimer's disease by modulating glutamine metabolism of the gut microbiome

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Food Science and Human Wellness 2024年第2期13卷 982-992页

作者： Guangsu Zhu Min Guo Jianxin Zhao Hao Zhang Gang Wang Wei Chen State Key Laboratory of Food Science and Resources Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China (Yangzhou)Institute of Food Biotechnology Jiangnan UniversityYangzhou 225004China National Engineering Center of Functional Food Jiangnan UniversityWuxi 214122China

The gut microbiota-brain axis has emerged as a novel target for Alzheimer's disease(AD),a neurodegenerative disease characterised by behavioural and cognitive ***,most previous microbiome-based intervention studies have focused on single factors and yielded only modest cognitive ***,we proposed a multidomain intervention strategy that combined Bifidobacterium breve treatment with environmental enrichment(EE)*** this study,we found that compared with EE or *** treatment alone,*** intervention combined with EE amplified its neuroprotective effects on AD mice,as reflected by improved cognition,inhibited neuroinflammation and enhanced synaptic ***,using microbiome and metabolome profiling,we found that the combination of *** and EE treatment restored AD-related gut microbiota dysbiosis and reversed microbial metabolite ***,by integrating behavioural and neurological data with metabolomic profiles,we revealed that the underlying mechanism may involve the modulation of microbiota-derived glutamine metabolism via gut-brain ***,combined *** intervention with EE treatment can alleviate AD-related cognitive impairment and improve brain function by regulating glutamine metabolism of the gut *** findings provide a promising multidomain intervention strategy,with a combination of dietary microbiome-based and lifestyle-targeted interventions,to promote brain function and delay the progression of AD.

关键词： Alzheimer’s disease Bifidobacterium breve environmental enrichment Glutamine metabolism Microbiota-gut-brain axis

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environmental enrichment combined with fasudil promotes motor function recovery and axonal regeneration after stroke

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Neural Regeneration Research 2021年第12期16卷 2512-2520页

作者： Yi-Tong Zhu Qun Zhang Hong-Yu Xie Ke-Wei Yu Gao-Jing Xu Si-Yue Li Yi Wu Department of Rehabilitation Medicine Huashan HospitalFudan UniversityShanghaiChina

Fasudil,a Rho-associated protein kinase(ROCK)inhibitor,has a protective effect on the central nervous *** addition,environmental enrichment is a promising technique for inducing the recovery of motor impairments in ischemic stroke *** present study aimed to explore whether environmental enrichment combined with fasudil can facilitate motor function recovery and induce cortical axonal regeneration after ***,a mouse model of ischemic cerebral stroke was established by photochemical embolization of the left sensorimotor *** solution(10 mg/kg per day)was injected intraperitoneally for 21 days after the photothrombotic *** environmental enrichment intervention was performed on days 7-21 after the photothrombotic *** results revealed that environmental enrichment combined with fasudil improved motor function,increased growth-associated protein 43 expression in the infarcted cerebral cortex,promoted axonal regeneration on the contralateral side,and downregulated ROCK,p-LIM domain kinase(LIMK)1,and p-cofilin *** combined intervention was superior to *** findings suggest that environmental enrichment combined with fasudil treatment promotes motor recovery after stroke,at least partly by stimulating axonal *** underlying mechanism might involve ROCK/LIMK1/cofilin pathway *** study was approved by the Institutional Animal Care and Use Committee of Fudan University,China(approval No.20160858A232)on February 24,2016.

关键词： axon regeneration biotinylated dextran amines environmental enrichment fasudil growth-associated protein 43 ischemic stroke motor recovery Nissl bodies Rho/ROCK pathway

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environmental enrichment promotes neural remodeling in newborn rats with hypoxic-ischemic brain damage

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Neural Regeneration Research 2011年第20期6卷 1548-1553页

作者： Chuanjun Liu Yankui Guo Yalu Li Zhenying Yang Department of Pediatrics Taian Health Centre for Women and Children Taian 271000 Shandong Province China Central Laboratory of Shandong Agricultural University Taian 271018 Shandong Province China Morphological Laboratory of Taishan Medical College Taian 271000 Shandong Province China

We evaluated the effect of hypoxic-ischemic brain damage and treatment with early environmental enrichment intervention on development of newborn rats, as evaluated by light and electron microscopy and morphometry. Early intervention with environmental enrichment intelligence training attenuated brain edema and neuronal injury, promoted neuronal repair, and increased neuronal plasticity in the frontal lobe cortex of the newborn rats with hypoxic-ischemic brain damage.

关键词： intelligence training environmental enrichment synaptic plasticity newborn rats hypoxic-ischemic brain damage neural regeneration

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environmental enrichment and Its Effect on the Welfare of Two Asian Elephants in Africam Safari Wildlife Conservation Park (Puebla, Mexico)

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Open Journal of Animal Sciences 2023年第4期13卷 496-512页

作者： Martha Trinidad Pérez Ramírez Nora Garcez Mercado María Rebeca Rojas Ronquillo Marco Antonio Alarcón Zapata Melina Maribel Ojeda Chi Carlos David Pérez Brígido Abigail Tabarez Rojas Faculty of Biological and Agricultural Sciences Veracruzana University Tuxpan Mexico

Animal welfare is important in zoos to maintain the physical well-being and psychological health of individuals. An animal is considered to have welfare if it has good nutrition and also expresses its innate behavior, including sensations and feelings experienced as a result of physical health. The objective of this study was to evaluate the effect of environmental enrichment on the behaviors of two Asian elephants in a wildlife conservation park. The behavior of two Asian elephants, a 46-year-old male and a 59-year-old female, was observed. Behavior was measured by quantifying the frequency, latency, and duration of behavioral actions. Measurements were done with ad libitum sampling during 5 days of testing, then observations were recorded with focal sampling for 25 days with environmental enrichment and 25 days without enrichment. Data were analyzed with the Chi-square statistical test using the statistical program SPSS 20, observing significant differences (P the application of environmental enrichment. The frequency of maintenance behaviors was higher when environmental enrichment was provided, and the frequency of social conducts (affiliative and agonistic) decreased. In fact, the behaviors most frequently presented by elephants with and without environmental enrichment were definitely maintenance behaviors. The environmental enrichment program helped to reduce the duration of abnormal behaviors and increase the frequency of typical behaviors of the species. It also increased independent movements within the exhibition area and helped to know each of the elephants individually in order to apply each enrichment combination according to their needs.

关键词： Asian Elephant Animal Welfare environmental enrichment Behavior

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environmental enrichment modifies ON-OFF visual processing in mouse primary visual cortex

Environmental enrichment modifies ON-OFF visual processing i...

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中国神经科学学会第十届全国学术会议

作者： Dinghong ZHANG Haishan YAO Institute of Neuroscience and State Key Laboratory of Neuroscience Shanghai Institutes for Biological SciencesChinese Academy of Sciences Graduate University of Chinese Academy of Sciences

Objective The information of light increments and decrements is processed by ON and OFF visual channels,which originate from the retina and converge for the first time in the primary visual cortex（V1）.Recent studies show that OFF-dominant neurons outnumber ON-dominant neurons in monkey and cat V1,and a study in our lab suggests that the OFF-dominance is matched to the prevalence of negative contrasts in natural ***,it remains unclear whether the relative strength of ON and OFF responses is influenced by visual *** this study,we examined the effect of environmental enrichment（EE） on the ON and OFF responses in mouse *** Mice were reared in standard or enriched *** to mice reared in the standard condition,enriched mice were reared in larger groups and stimulated by a variety of *** measured ON and OFF RFs of V1 neurons using two-dimensional sparse noise *** We found that EE enhanced the degree of OFF-dominance in *** enhancement of OFF-dominance was observed across different cortical layers,and the effect can be observed in mice exposed to various durations of EE,including EE for 2 months,1 month,and 1 *** Our results add to the literature that examines the influence of EE on brain function,and provide the first evidence that the relative strength of ON and OFF responses can be modified by sensory experience.

关键词： environmental enrichment primary visual cortex ON/OFF response

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Vertically-Suspended environmental enrichment Improves Growth of Landlocked Fall Chinook Salmon during Initial Hatchery Rearing

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Open Journal of Applied Sciences 2020年第11期10卷 725-731页

作者： Nathan Huysman Jill M. Voorhees Eric Krebs Michael E. Barnes South Dakota Game Fish and Parks McNenny State Fish Hatchery Spearfish USA

environmental enrichment has been shown to improve juvenile salmonid growth during hatchery rearing. This study examined the effects of vertically-suspended environmental enrichment starting seven days after feed training and continuing for the next 32 days of landlocked fall Chinook salmon (Oncorhynchus tshawytscha) rearing. At the end of this experiment, final tank weights, gain, percent gain, and feed conversion ratio were all significantly improved in the tanks of salmon with environmental enrichment compared to barren tanks, with a nearly 25% improvement in feed conversion ratio. Individual salmon in tanks with environmental enrichment were significantly longer and weighed significantly more than salmon from tanks without enrichment. Specific growth rate was also significantly improved with the use of enrichment. The use of vertically-suspended environmental enrichment to improve growth and rearing efficiency is recommended during the initial rearing of landlocked fall Chinook salmon.

关键词： Oncorhynchus tshawytscha environmental enrichment Structure Initial Feeding

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Seniors’ experiences of visual art environmental enrichment

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Open Journal of Nursing 2013年第2期3卷 163-168页

作者： Lars Olov Bygren Birgitta Nasman Britt-Maj Wikstrom Benson BKonlaan Ann-Brith Karlsson Eva Elgh Andrej MGrjibovski Sven Sandström Department of Biosciences and Nutrition Karolinska InstituteHuddingeSweden Department of Community Medicine and Rehabilitation University of UmeaUmeaSweden Oslo and Akershus University College Faculty of Health SciencesOsloNorway Swedish Red Cross University College of Nursing StockholmSweden Norwegian Institute of Public Health OsloNorway International School of Public Health Northern State Medical UniversityArkhangelskRussia Department of Art History University of LundLundSweden

The present study aimed at determining whether short-term exposure to art in shared common areas in congregate housing units could affect health and health determinants among the residents. Ten residents (mean age 80.4 years) at one block were exposed to visual art environmental enrichment in common areas over a period of three months. Thirteen persons (mean age 86.6 years) living in another block played in-house boule. Cornell’s test, Mini-Mental tests (MMT), and face recognition test were performed to assess depression, cognition, and episodic memory, respectively before and after the intervention. The results show that visual art environmental enrichment in common areas and lack of stimulating and guiding dialogues show a change in depression scores in the intervention group (p = 0.018) and the control group (p = 0.009). MMT scores improved only in the control group (p = 0.003). No changes in episodic memory in any of the groups were observed. It could be concluded that in order to obtain a positive result of short term visual art environmental enrichment, guiding art dialogues conducted by nurses, as described in previous research, should be added to visual art environmental enrichment in healthcare settings.

关键词： Health Professionals Elderly Depression Visual Art environmental enrichment Memory

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Impact of Vertically-Suspended environmental enrichment and Two Densities of Fish on Circular Tank Velocity Profiles

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Engineering（科研） 2020年第10期12卷 723-738页

作者： Joshua M. A. Caasi Joseph M. Barnes Michael E. Barnes Benedictine College School of Engineering Atchison Kansas USA South Dakota Department of Game Fish and Parks McNenny State Fish Hatchery Spearfish South Dakota USA

Vertically-suspended environmental enrichment has been shown to produce improvements in fish growth during hatchery rearing in circular tanks. This study documented the effects of a novel suspended structure on the velocity profile of a 3.63-m diameter circular tank containing juvenile landlocked fall Chinook salmon (Oncorhynchus tshawytscha) at two different densities (9.0 and 34.3 kg/m3). The addition of vertically-suspended structure to the tank significantly decreased velocities at nearly every sampling point, with velocities typically dropping from 15 cm/s without structure to less than 6 cm/s when structure was present. Fish density also significantly impacted in-tank velocities, with an inverse relationship observed between the density of fish and water velocity. Significant interactions were present among the presence or absence of structure and fish density. When structure and fish were absent, the velocity at the edge of the tank was 15.63 cm/s, which was significantly higher than the 4.75 cm/s velocity when both structure and the lower fish density were added, which was in turn significantly higher than the 2.29 cm/s velocity observed with structure and higher fish density. Despite the potentially unique features of this study, vertically-suspended environmental enrichment and the presence of fish clearly alter circular tank water velocities, which may at least partially explain the improvements in fish rearing performance observed with the use of suspended structure.

关键词： Circular Tank Velocity environmental enrichment Fish Density

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Memantine combined with environmental enrichment improves spatial memory and alleviates Alzheimer's disease-like pathology in senescence-accelerated prone-8(SAMP8) mice

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The Journal of Biomedical Research 2012年第6期26卷 439-447页

作者： Jingde Dong Mi Zhou Xiaoqiang Wu Mingyang Du Xiaoshan Wang Department of Geriatric Neurology Department of Neurology Nanjing Brain Hospital Affiliated to Nanjing Medical UniversityNanjingJiangsu 210029China.

Memantine is a N-methyl-D-aspartate (NMDA) receptor antagonist approved for the treatment of moderate to severe Alzheimer's disease (AD). environmental enrichment (EE) has shown significant beneficial effects on func- tional improvement in AD. In this study, we sought to determine whether combining these two distinct therapies would yield greater benefit than either drug used alone. We investigated the effect of memantine combined with EE on spatial learning and memory and AD-like pathology in a widely used AD model, the senescence-accelerated prone mice (SAMP8). The SAMP8 mice were randomly assigned to enriched housing (EH) or standard housing (SH), where either memantine (20 mg/kg) or saline was given by gastric lavage once daily continuously for eight weeks. Our results showed that, when provided separately, memantine and EE significantly improved spatial learning and memory by shortening escape latencies and increasing the frequency of entrance into the target quadrant. When combined, memantine and EE showed additive effect on learning and memory as evidenced by significant shorter escape latencies and higher frequency of target entrance than either drug alone. Consistent with the behavior results, pathological studies showed that both memantine and EE significantly reduced hippocampal CA1 neurofibrilliary tangles (NFTs) as well as amyloid beta precursor protein (APP) levels. Combining both therapies synergistically lessened NFTs and APP expression compared to either drug alone in SAMP8 mice, indicating that the combination of memantine with EE could offer a novel and efficient therapeutic strategy for the treatment of AD.

关键词： memantine environmental enrichment SAMP8 mouse spatial memory Alzheimer's disease (AD)

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The effects of environmental enrichment rearing on performance in learning and memory tasks in mice

The effects of environmental enrichment rearing on performan...

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Jing-Jing ZHENG~(1,2),Xiang YU~(1,*) 1 Lab of Dendritic Development and Neural Circuit Formation,Institute of Neuroscience and State Key Laboratory of Neuroscience,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai 200031,China. 2 Graduate School of the Chinese Academy of Sciences,Shanghai 200031,China

＜正＞environmental enrichment（EE） rearing has been used extensively a model for naturally increasing neural *** work has been done in EE reared mice,showing that this paradigm can increase neural plasticity and enhance the acquisition and consolidation of ***,most of the previously used enrichment paradigms were targeted at juvenile and adult rodents,and not the developing *** our laboratory,we are interested in the effects of naturally increasing neural activity on neural circuit development,and thus set up an EE paradigm for neonatal *** aim of the present study is to test if EE rearing may result in better performance in various behavioral *** has been suggested that differences in maternal behavior between enriched and non-enriched conditions could contribute to the effects of EE *** care behaviors were video recorded and analyzed at 2 min intervals from postnatal day 1 until 8,and the percentage time each dam spent licking,grooming,arched-back nursing,passive nursing,nesting or having no contact with pups were *** with published results,we observe an increase in the frequency of maternal care events in enriched mice compared to *** of control and EE mice were also tested in several learning and memory tasks including cued and contextual fear conditioning,spatial memory and paired association ***,EE mice performed better than control mice in all these tasks,showing that EE rearing of neonatal pups increases the acquisition and consolidation of memory in both simple and complex behavioral *** future experiments, we will assess if EE rearing can reverse some of the learning and memory defects in mouse models of various developmental disorders.

关键词： environmental enrichment maternal care behavior fear conditioning

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