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Impacts of cold exposure on energy metabolism

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Frigid Zone Medicine 2024年第2期4卷 65-71页

作者： Miao Yan Shanjie Wang Shaohong Fang Mingyan E Bo Yu Department of Cardiology Second Affiliated Hospital of Harbin Medical UniversityHarbin 150001China The Key Laboratory of Myocardial Ischemia Chinese Ministry of EducationHarbin 150001China Department of Thoracic Radiotherapy Harbin Medical University Cancer HospitalHarbin 150081China

Cold stimulation has been shown to regulate glucose,lipid,and amino acid metabolism,while also increasing heat production and energy expenditure in the *** energy metabolism is a key factor in the onset and progression of chronic metabolic conditiones such as diabetes,obesity,and cardiovascular *** research has unveiled the myriad pathways through which cold stimulation affects human energy *** article provides an overview of how cold stimulation affects energy metabolism across the three major metabolic ***,it explores the implications and potential therapeutic applications of cold stimulation in the prevention and treatment of various metabolic diseases.

关键词： cold stimulation energy metabolism glucose metabolism lipid metabolism amino acid metabolism chronic metabolic diseases

energy metabolism disorders and potential therapeutic drugs in heart failure

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Acta Pharmaceutica Sinica B 2021年第5期11卷 1098-1116页

作者： Yanan He Wei Huang Chen Zhang Lumeng Chen Runchun Xu Nan Li Fang Wang Li Han Ming Yang Dingkun Zhang State Key Laboratory Breeding Base of Systematic Research Development and Utilization of Chinese Medicine ResourcesChengdu University of Traditional Chinese MedicineChengdu 611137China Jiangxi University of Traditional Chinese Medicine Nanchang 330004China The College of Pharmacy Chengdu University of Traditional Chinese MedicineChengdu 611137China

Heart failure(HF)is a global public health problem with high morbidity and mortality.A large number of studies have shown that HF is caused by severe energy metabolism disorders,which result in an insufficient heart energy *** deficiency causes cardiac pump dysfunction and systemic energy metabolism failure,which determine the development of HF and recovery of *** HF therapy acts by reducing heart rate and cardiac preload and afterload,treating the HF symptomatically or delaying development of the *** aimed at cardiac energy metabolism have not yet been *** this review,we outline the main characteristics of cardiac energy metabolism in healthy hearts,changes in metabolism during HF,and related pathways and targets of energy ***,we discuss drugs that improve cardiac function via energy metabolism to provide new research ideas for the development and application of drugs for treating HF.

关键词： Heart failure energy deficit Cardiac dysfunction energy metabolism Substrate metabolism Hormones Natural products Synthetic drugs

Dimethyl phthalate damages Staphylococcus aureus by changing the cell structure, inducing oxidative stress and inhibiting energy metabolism

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Journal of Environmental Sciences 2021年第9期33卷 171-183页

作者： Xiaohui Zhu Hong Liu Zhigang Wang Renmao Tian Shenglin Li School of Life Science and Agriculture Forestry Qiqihar UniversityQiqiharHeilongjiang 161006China Heilongjiang Provincial Technology Innovation Center of Agromicrobial Preparation Industrialization Qiqihar 161006China Institute for Food Safety and Health Illinois Institute of TechnologyChicagoIL 60501USA Key Laboratory of Saline-alkali Vegetation Ecology Restoration Ministry of EducationCollege of Life SciencesNortheast Forestry UniversityHarbin 150040China

Dimethyl phthalate(DMP), used as a plasticizer in industrial products, exists widely in air,water and *** aureus is a typical model organism representing Gram-positive *** molecular mechanisms of DMP toxicology in *** were researched by proteomic and transcriptomic *** results showed that the cell wall, membrane and cell surface characteristics were damaged and the growth was inhibited in *** by *** stress was induced by DMP in *** activities of succinic dehydrogenase(SDH) and ATPase were changed by DMP, which could impact energy *** on proteomic and transcriptomic analyses, the oxidative phosphorylation pathway was enhanced and the glycolysis/gluconeogenesis and pentose phosphate pathways were inhibited in *** exposed to *** results of real-time reverse transcription quantitative PCR(RT-qPCR) further confirmed the results of the proteomic and transcriptomic *** acid, pyruvic acid and glucose were reduced by DMP in ***, which suggested that DMP could inhibit energy *** results indicated that DMP damaged the cell wall and membrane, induced oxidative stress, and inhibited energy metabolism and activation in ***.

关键词： Dimethyl phthalate Staphylococcus aureus Cell micro-interface Oxidative stress energy metabolism Proteomics and transcriptomics analyses

energy metabolism and survival of liver grafts from non-heart-beating donor rats with warm ischemia injury

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Hepatobiliary & Pancreatic Diseases International 2006年第4期5卷 521-525页

作者： Yi Ma, Lin-Wei Wu, Jin-Liang Wu, Ying-Jie Liang, Zhen-Yu Zhu, Rui-De Hu and Xiao-Shun He Organ Transplantation Center, First Affiliated Hospital , Molecular Medicine Center Department of Pathology , Sun Yat-Sen University, Guangzhou 510080, China Organ Transplantation Center First Affiliated Hospital Sun Yat-Sen University Guangzhou 510080 China. anhuimayi2002@***

BACKGROUND: The shortage of donor livers is a critical limiting factor for the use of liver transplantation in treatment of end-stage liver diseases. Organs from non- heart-beating donors seem to be an effective option to alleviate this problem. Warm ischemia injury, however, directly influences the grafts' activity and functional recovery after operation. We investigated the energy metabolism and post-transplant survival of liver grafts after different warm ischemia times (WITs) in rats and determined the maximum limit for liver grafts with warm ischemia. METHODS: Rats were randomized into 7 groups with WITs of 0 (control), 10, 15, 20, 30, 45 or 60 minutes. The indices of energy metabolism were measured by reversed- phase high performance liquid chromatograpy and all liver graft specimens were subjected to ultrastructural observation. After orthotopic liver transplantation (OLT), the recovery of energy metabolism in liver grafts after 24 and 48 hours and the survival of the rats were assessed. RESULTS: The levels of adenosine triphosphate (ATP) and energy charge (EC) decreased gradually after different WITs in a time-dependent manner, and this was especially significant within 30 minutes. The levels of ATP and EC in liver grafts with 30 minutes of warm ischemia largely recovered 24 hours after OLT, with 45 minutes of warm ischemia partially recovered 48 hours after OLT, and with 60 minutes of warm ischemia, hardly recovered even 48 hours after OLT. The survival time after OLT did not significantly change with up to 30 minutes of WIT, while long-term survival was reduced with 45 and 60 minutes of ***: The levels of ATP and EC after OLT may be important criteria for evaluating the quality of a liver graft. The WIT of a liver graft is closely related to the recovery of hepatic energy metabolism and the graft survival.

关键词： liver transplantation warm ischemia injury energy metabolism

Improving Blood Monocyte energy metabolism Enhances Its Ability to Phagocytose Amyloid-βand Prevents Alzheimer’s Disease-Type Pathology and Cognitive Deficits

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Neuroscience Bulletin 2023年第12期39卷 1775-1788页

作者： Zhi-Hao Liu Yu-Di Bai Zhong-Yuan Yu Hui-Yun Li Jie Liu Cheng-Rong Tan Gui-Hua Zeng Yun-Feng Tu Pu-Yang Sun Yu-Juan Jia Jin-Cai He Yan-Jiang Wang Xian-Le Bu Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou325000China Department of Neurology and Centre for Clinical Neuroscience Daping HospitalThird Military Medical UniversityChongqing400042China Chongqing Key Laboratory of Ageing and Brain Diseases Chongqing400042China Institute of Brain and Intelligence Third Military Medical UniversityChongqing400042China State Key Laboratory of Trauma Burns and Combined InjuryThird Military Medical UniversityChongqing400042China Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai201200China

Deficiencies in the clearance of peripheral amyloidβ(Aβ)play a crucial role in the progression of Alzheimer’s disease(AD).Previous studies have shown that the ability of blood monocytes to phagocytose Aβis decreased in ***,the exact mechanism of Aβclearance dysfunction in AD monocytes remains *** the present study,we found that blood monocytes in AD mice exhibited decreases in energy metabolism,which was accompanied by cellular senescence,a senescence-associated secretory phenotype,and dysfunctional phagocytosis of Aβ.Improving energy metabolism rejuvenated monocytes and enhanced their ability to phagocytose Aβin vivo and in ***,enhancing blood monocyte Aβphagocytosis by improving energy metabolism alleviated brain Aβdeposition and neuroinflammation and eventually improved cognitive function in AD *** study reveals a new mechanism of impaired Aβphagocytosis in monocytes and provides evidence that restoring their energy metabolism may be a novel therapeutic strategy for AD.

关键词： Alzheimer's disease Aβclearance Monocyte Phagocytosis energy metabolism

Metformin improves boar sperm quality via 5′-AMPactivated protein kinase-mediated energy metabolism in vitro

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Zoological Research 2020年第5期41卷 527-538页

作者： Rong-Nan Li Zhen-Dong Zhu Yi Zheng Ying-Hua Lv Xiu-E Tian De Wu Yong-Jun Wang Wen-Xian Zeng Key Laboratony for Anima/Genetics Breeding and Reproduction of Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest A&F UniversityYanglingShaanxi 712100China Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education of China Institute of Animal NutntionSichuan Agricultural UniversityChengduSichuan 611100China

Sperm are specialized cells that require adenosine triphosphate(ATP) to support their *** sperm energy homeostasis in vitro is vitally important to improve the efficacy of boar sperm preservation. Metformin can activate 5′-AMPactivated protein kinase(AMPK) to improve metabolic flexibility and maintain energy homeostasis. Thus, the aim of the present study was to investigate whether metformin can improve boar sperm quality through AMPK mediation of energy metabolism. Sperm motility parameters, membrane integrity,acrosomeintegrity,mitochondrial membrane potential(ΔΨm), ATP content, glucose uptake,and lactate efflux were *** and expression levels of AMPK and phospho-Thr172-AMPK(p-AMPK) were also detected by immunofluorescence and western blotting. We found that metformin treatment significantly increased sperm motility parameters, ΔΨm, and ATP content during storage at 17 ℃. Moreover, results showed that AMPK was localized at the acrosomal region, connecting piece, and midpiece of sperm and p-AMPK was distributed at the post-acrosomal region, connecting piece, and midpiece. When sperm were incubated with metformin for 4 h at 37 ℃, sperm motility parameters, ΔΨm, ATP content,p-AMPK, glucose uptake, and lactate efflux all significantly increased, whereas the addition of Compound C treatment, an inhibitor of AMPK,counteracted these positive effects. Together, our results suggest that metformin promotes AMPK activation, which contributes to the maintenance of energy hemostasis and mitochondrial activity,thereby maintaining boar sperm functionality and improving the efficacy of semen preservation.

关键词： Metformin AMPK Sperm energy metabolism Glycolysis

Oxidative stress disturbs energy metabolism of mitochondria in ethanol-induced gastric mucosa injury

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World Journal of Gastroenterology 2008年第38期14卷 5857-5867页

作者： Jin-Shui Pan Division of Gastroenterology Zhongshan Hospital Xiamen University Xiarnen 361004 Fujian Province China Gastroenterology Institute of Xiamen University Xiamen 361004 Fujian Province China Gastroenterology Center of Xiamen Xiamen 361004 Fujian Province China Intensive Care Unit the First Hospital of Zhangzhou Zhangzhou 363000 Fujian Province China

AIM: To study the role of mitochondrial energy disorder in the pathogenesis of ethanol-induced gastric mucosa injury. METHODS: Wistar rats were used in this study. A gastric mucosal injury model was established by giving the rats alcohol. Gross and microscopic appearance of gastric mucosa and ultrastructure of mitochondria were evaluated. Malondiadehyde (MDA) in gastric mucosa was measured with thiobarbituric acid. Expression of ATP synthase (ATPase) subunits 6 and 8 in mitochondrial DNA (mtDNA) was determined by reverse transcription polymerase chain reaction (RT- PCR). RESULTS:The gastric mucosal lesion index was correlated with the MDA content in gastric mucosa. As the concentration of ethanol was elevated and theexposure time to ethanol was extended, the content of MDA in gastric mucosa increased and the extent of damage aggravated. The ultrastructure of mitochondria was positively related to the ethanol concentration and exposure time. The expression of mtDNA ATPase subunits 6 and 8 mRNA declined with the increasing MDA content in gastric mucosa after gavage with ethanol. CONCLUSION: Ethanol-induced gastric mucosa injury is related to oxidative stress, which disturbs energy metabolism of mitochondria and plays a critical role in the pathogenesis of ethanol-induced gastric mucosa injury.

关键词： Animal model Ethanol Gastric mucosa Oxygen free radical energy metabolism

Epigenetic regulation of energy metabolism in obesity

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Journal of Molecular Cell Biology 2021年第7期13卷 480-499页

作者： Wei Gao Jia-Li Liu Xiang Lu Qin Yang Department of Geriatrics Sir Run Run HospitalNanjing Medical UniversityNanjing 211166China Key Laboratory for Aging&Disease Nanjing Medical UniversityNanjing 211166China Department of Medicine Physiology and BiophysicsUC Irvine Diabetes CenterUniversity of California IrvineIrvineCA 92697USA

Obesity has reached epidemic proportions *** modern adoption of a sedentary lifestyle coupled with energy-dense nutrition is considered to be the main cause of obesity epidemic,genetic preposition contributes significantly to the imbalanced energy metabolism in ***,the variants of genetic loci identified from large-scale genetic studies do not appear to fully explain the rapid increase in obesity epidemic in the last four to five *** advancements of next-generation sequencing technologies and studies of tissue-specific effects of epigenetic factors in metabolic organs have significantly advanced our understanding of epigenetic regulation of energy metabolism in *** epigenome,including DNA methylation,histone modifications,and RNA-mediated processes,is characterized as mitotically or meiotically heritable changes in gene function without alteration of DNA ***,epigenetic modifications are ***,comprehensively understanding the landscape of epigenetic regulation of energy metabolism could unravel novel molecular targets for obesity *** this review,we summarize the current knowledge on the roles of DNA methylation,histone modifications such as methylation and acetylation,and RNA-mediated processes in regulating energy *** also discuss the effects of lifestyle modifications and therapeutic agents on epigenetic regulation of energy metabolism in obesity.

关键词： obesity epigenetics energy metabolism treatment

Combination of Total Astragalus Extract and Total Panax Notoginseng Saponins Strengthened the Protective Effects on Brain Damage through Improving energy metabolism and Inhibiting Apoptosis after Cerebral Ischemia-Reperfusion in Mice

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Chinese Journal of Integrative Medicine 2017年第6期23卷 445-452页

作者： HUANG Xiao-ping TAN Hua CHEN Bei-yang DENG Chang-qing Key Laboratory of Hunan Universities for Cell Biology and Molecular Techniques Key Laboratory of Hunan Province for Prevention and Treatment of Integrated Traditional Chinese and Western Medicine on Cardio-Cerebral DiseasesHunan University of Chinese MedicineChangsha 410007China Department of Histology and Embryology Hunan University of Chinese MedicineChangsha 410208China

Objective： To explore the effects and molecular mechanisms of the combination between total Astragalus extract （TAE） and total Panax notoginseng saponins （TPNS） against cerebral ischemia- reperfusion injury. Methods： C57BL/6 mice were randomly divided into sham-operated group, model group, TAE （110 mg/kg） group, TPNS （115 mg/kg） group, TAE-TPNS combination group and Edaravone （4 mg/kg） group, treated for 4 days, then, cerebral ischemia-repeffusion injury was established by bilateral common carotid artery （CCA） ligation for 20 min followed by reperfusion for 1 and 24 h. Results： TPNS could increase adenosine triphosphate （ATP） level, TAE and TAE-TPNS combination increased ATP, adenosine diphosphate （ADP） contents and Na＋-K＋-ATPase activity, and the effects of TAE-TPNS combination were stronger than those of TAE or TPNS alone after reperfusion for 1 h. After reperfusion for 24 h, TAE, TPNS and TAE-TPNS combination significantly increased neurocyte survival rate and decreased the apoptosis rate as well as down-regulated the expression of phosphorylated c-June N-terminal kinasel/2 （p-JNK1/2）, cytochrome C （Cyt C）, cysteine aspartic acid-specific protease （Caspase）-9 and Caspase-3. Furthermore, the effects in TAE-TPNS combination were better than those in TAE or TPNS alone. Conclusion： The combination of TAE 110 mg/kg and TPNS 115 mg/kg could strengthen protective effects on cerebral ischemia injury, the mechanism underlying might be related to improving jointly the early energy metabolism, and relieving the delayed apoptosis via inhibiting the mitochondrial apoptosis pathway of JNK signal transduction.

关键词： total Astragalus extract total Panax notoginseng saponins combination cerebral ischemia- reperfusion energy metabolism C-Jun N-terminal kinase signal transduction mitochondrial apoptosis pathway Chinese medicine