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Evaluation of endocrine disruption and dioxin-like effects of organic extracts from sewage sludge in autumn in Beijing, China

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Frontiers of Environmental Science & Engineering 2014年第3期8卷 433-440页

作者： Cao LIU Yiping XU Mei MA Bingbin HUANG Jingdong WU Qingyi MENG Zijian WANG Robert Alan GEARHEART State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China Beijing Water Science and Technology Institute Beijing 100048 China Environmental Engineering Department Humboldt State University Arcata CA95521 USA

Study on effective disposal and utilization of sewage sludge has recently been the target of growing interest in China. However, potential risks are associated with the use of sludge due to its contamination with toxic organics, heavy metals and pathogenic microorganisms. In this study, a screening assessment was conducted on sewage sludge samples collected from 17 different sewage treatment plants in Beijing, based on a batch of in vitro bioassays, including a set of recombinant gene yeast assays for endocrine disruption, and an ethoxy resorufin-O- deethylase （EROD） assay using H4IIE cells for aryl hydrocarbon receptor （Ah-R） agonistic activities. Our results suggested that moderate levels of estrogen receptor agonistic activities （0.9 ng E2. g-1 to 6.8 ng E2. gl, dw）, but relative higher androgen receptor antagonistic activ- ities （nd to 45%）, progestin receptor antagonistic activities （nd to 80%） and Ah-R agonistic activities （1390 to 6740 pg 2,3,7,8-tetrachlorodibenzo-p-dioxin （TCDD）·g-1, dw） were found in sewage sludge samples. However, there were no significant correlations between the toxic effects of sewage sludge and the sewage treatment processes. In addition, the 17β-estradiol （E2） equivalent quantity （EEQ） level of the sewage sludge was increased after the composting treatment, whereas the 2,3,7,8-tetrachlorodi- benzo-p-dioxin toxic equivalent quantity （TEQ） level of sewagesludge composted was much lower than that of sewage sludge.

关键词： sewage sludge in vitro bioassay endocrine disruption dioxin-like effect

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Hypoxic and temporal variation in the endocrine disrupting toxicity of perfluorobutanesulfonate in marine medaka(Oryzias melastigma)

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Journal of Environmental Sciences 2024年第2期136卷 279-291页

作者： Baili Sun Jing Li Yachen Bai Xiangzhen Zhou Paul K.S.Lam Lianguo Chen State Key Laboratory of Freshwater Ecology and Biotechnology Institute of HydrobiologyChinese Academy of SciencesWuhan 430072China University of Chinese Academy of Sciences Beijing 100049China Office of the President Hong Kong Metropolitan University30 Good Shepherd StreetKowloonHong Kong SARChina

Perfluorobutanesulfonate(PFBS)is an emerging pollutant capable of potently disrupting the sex and thyroid endocrine systems of ***,the hypoxic and temporal variation in PFBS endocrine disrupting toxicity remain largely *** the present study,adult marine medaka were exposed to environmentally realistic concentrations of PFBS(0 and 10μg/L)under normoxia or hypoxia conditions for 7 days,aiming to explore the interactive behavior between PFBS and *** addition,PFBS singular exposure was extended till 21days under normoxia to elucidate the time-course progression in PFBS *** results showed that hypoxia inhibited the growth and caused the suspension of egg spawn regardless of PFBS *** regard to the sex endocrine system,7-day PFBS exposure led to an acute stimulation of transcriptional profiles in females,which,subsequently,recovered after the 21-day *** potency of hypoxia to disturb the sex hormones was much stronger than PFBS.A remarkable increase in estradiol concentration was noted in medaka blood after hypoxia *** in sex endocrinology of coexposed fish were largely determined by hypoxia,which drove the formation of an estrogenic *** further enhanced the endocrine disrupting effects of ***,the hepatic synthesis of vitellogenin and choriogenin,two commonly used sensitive biomarkers of estrogenic activity,failed to initiate in response to the estrogen *** to sex endocrine system,disturbances in thyroidal axis by PFBS or hypoxia were relatively ***,the present findings will advance our toxicological understanding about PFBS pollutant under the interference of hypoxia.

关键词： Perfluorobutanesulfonate(PFBS) Aquatic hypoxia Temporal toxicity Combined exposure endocrine disruption Marine medaka

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Full sexual maturity-cycle exposure to environmentally relevant concentrations of 17β-estradiol decreases reproductive capacity of zebrafish

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Journal of Environmental Sciences 2024年第3期137卷 580-592页

作者： Yongkang Zhang Yuanjun Jiang Qian Sun Meng Li Sheng Chen Jingyu Liang Chunsheng Liu College of Fisheries Huazhong Agricultural UniversityWuhan 430070China School of Environmental Studies China University of GeosciencesWuhan 430074China

17β-Estradiol(E2)has been widely detected in natural water and treatment with E2 induces potential endocrine disrupting effects in ***,effects on fish fecundity and steroid system after treatment with environmentally relevant concentrations of E2 for the full sexual maturation cycle remain *** this study,zebrafish were treatment with 0,10 or100 ng/L E2 from embryo to adult stage,and effects on gonadal development and differentiation,steroid hormone levels,transcription of genes associated with the hypothalamic-pituitary-gonadal-liver(HPG)axis in adults and fertilization rate of offspring were *** results showed that treatment with E2 lead to increased number of feminization in *** females,E2 decreased cumulative amount of spawning and inhibited the maturation of *** males,E2 inhibited the maturation and motility of sperm,as well as decreased the movement speed of *** adverse effects on sperm might be responsible for the reduced fertilization observed in *** addition,treatment with E2 changed the levels of steroid hormones in zebrafish gonad and altered the transcriptional levels of genes associated with HPG axis,which is responsible for the regulation of germ cells maturation and gonadal development in ***,these results suggested that treatment with environmentally relevant concentrations of E2 for the full sexual maturity cycle resulted in adverse effects on reproduction in zebrafish.

关键词： Environmental estrogen Zebrafish Fecundity Gonadal development endocrine disruption

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Species-dependent effects of the phenolic herbicide ioxynil with potential thyroid hormone disrupting activity: modulation of its cellular uptake and activity by interaction with serum thyroid hormone-binding proteins

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Journal of Environmental Sciences 2012年第5期24卷 949-955页

作者： Sakura Akiyoshi Gobun Sai Kiyoshi Yamauchi Department of Biological Science Faculty of Science Shizuoka University

Ioxynil, a phenolic herbicide, is known to exert thyroid hormone （TH） disrupting activity by interfering with TH-binding to plasma proteins and a step of the cellular TH-signaling pathway in restricted animal species. However, comparative studies are still lacking on the TH disruption. We investigated the interaction of [125I] ioxynil with serum proteins from rainbow trout, bullfrog, chicken, pig, rat, and mouse, using native polyacrylamide gel electrophoresis. Candidate ioxynil-binding proteins, which included lipoproteins, albumin and transthyretin （TTR）, differed among the vertebrates tested. Rainbow trout and bullfrog tadpole serum had the lowest binding activity for ioxynil, whereas the eutherian serum had the highest binding activity. The cellular uptake of, and response to, ioxynil were suppressed by rat serum greater than by tadpole serum. The cellular uptake of [125I]ioxynil competed strongly with phenols with a single ring, but not with THs. Our results suggested that ioxynil interferes with TH homeostasis in plasma and with a step of cellular TH-signaling pathway other than TH-uptake system, in a species-specific manner.

关键词： endocrine disruption ioxynil thyroid hormone serum transthyretin uptake

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Sea Nine 211 as antifouling biocide: A coastal pollutant of emerging concern

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Journal of Environmental Sciences 2017年第11期29卷 68-79页

作者： Lianguo Chen James C.W.Lam State Key Laboratory in Marine Pollution City University of Hong Kong Department of Science and Environmental Studies The Education University of Hong Kong

Sea Nine 211, with 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one（DCOIT） being the biocidal ingredient, is a widely-used antifouling agent to deter the undesirable biofouling phenomenon. It is commercially promoted as an environmentally acceptable antifoulant mainly due to its claimed rapid degradation in marine environment. However, increasing researches document varying degradative kinetics in different environments, proving that Sea Nine 211 is actually not degraded equally fast around the world（half-life between〈 1 day and 13.1 days）. Large-scale application of Sea Nine 211 in antifouling coatings has also caused global contamination of marine environment in various compartments. For example, accumulation of Sea Nine 211 is detected as high as 3700 ng/L in Spanish seawater and 281 ng/g dry weight in Korean sediment. Considering that Sea Nine 211 is highly toxic against non-target marine organisms, environmental risk assessment finds that most marine organisms are endangered by Sea Nine 211 in worst-case scenario. Its endocrine disrupting and reproductive impairing effects at environmentally worst-case concentrations further constitute a long-term threat to the maintenance of population ***, in the light of the varying degradability, environmental pollution and high toxicity, especially the endocrine disruption, Sea Nine 211 as an antifouling agent is likely to cause non-negligible damages to the marine ecosystem. There is an urgency to perform a systematic ecological risk assessment of Sea Nine 211 to prevent the potential impacts on the health of marine environment. A regular monitoring also becomes necessary to place the usage of antifouling biocides under control.

关键词： Sea Nine 211 Antifouling agent Degradation Environmental occurrences Ecological risks endocrine disruption

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endocrine disrupting effects on Chinese rare minnow(Gobiocypris rarus) fed with field collected Limnodrilus sp.

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Journal of Environmental Sciences 2004年第5期16卷 784-787页

作者： MATao-wu WANGZi-jian LIUJian-kang StateKeyLaboratoryofEnvironmentalAquaticChemistry ResearchCenterforEco-EnvironmentalSciencesChineseAcademyofSciencesBeijing100085China InstituteofHydrobiology ChineseAcademyofSciencesWuhan430072China

The potential endocrine disrupting effects and other toxicity effects on aquatic biota resulted from food uptake was simulated by feeding the laboratory cultured rare minnow(Gobiocypris rarus) with field collected Limnodrilus sp. The results indicated that the food chain processes affected significantly the growth, slightly reduced gonadosomatic indices, and elevated hepatosomatic indices. There was an obvious vitellogenin(VTG) induction, which generally only occurred in mature female, in the serum of juvenile rare minnow and mature male when fed with Limnodrilus sp. In addition, the rare minnow feeding on Limnodrilus sp. had significantly high renal indices, it meant obvious renal hyperplasia. The present work suggested that Limnodrilus sp. from field water may contain toxic pollutants and could lead to endocrine disruption effects to the predators. It was concluded that endocrine disruptors may not only be assimilated through water, but also be bioconcentrated through food web. The results also suggested the importance of food selection in conducting the study of endocrine disruption effects using sensitive species.

关键词： rare minnow(Grobiocypris rarus) Limnodrilus sp. endocrine disruption food chain vitellogenin

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Persistent organic pollutants and male reproductive health

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Asian Journal of Andrology 2014年第1期16卷 71-80页

作者： Anne Vested Aleksander Giwercman Jens Peter Bonde Gunnar Toil- Department of Occupational Medicine Danish Ramazzini Centre Aarhus University Hospital Aarhus Denmark Reproductive Medicine Centre Lund University Skane University Hospital Malm6 Sweden Department of Occupational and Environmental Medicine Bispebjerg Hospital of Copenhagen University

Environmental contaminants such as persistent organic pollutants （POPs） are man-made bioaccumulative compounds with long half-lives that are found throughout the world as a result of heavy use in a variety of consumer products during the twentieth century. Wildlife and animal studies have long suggested adverse effects of exposure to these compounds on human reproductive health, which, according to the endocrine disrupter hypothesis, are ascribed to the compounds＇ potential to interfere with endocrine signaling, especially when exposure occurs during certain phases of fetal and childhood development. An extensive number of epidemiological studies have addressed the possible effects of exposure to POPs on male reproductive health, but the results are conflicting. Thus far, most studies have focused on investigating exposure and the different reproductive health outcomes during adulthood. Some studies have addressed the potential harmful effects of fetal exposure with respect to malformations at birth and/ or reproductive development, whereas only a few studies have been able to evaluate whether intrauterine exposure to POPs has long-term consequences for male reproductive health with measurable effects on semen quality markers and reproductive hormone levels in adulthood. Humans are not exposed to a single compound at a time, but rather, to a variety of different substances with potential divergent hormonal effects. Hence, how to best analyze epidemiological data on combined exposures remains a significant challenge. This review on POPs will focus on current knowledge regarding the potential effects of exposure to POPs during fetal and childhood life and during adulthood on male reproductive health, including a critical revision of the endocrine disruption hypothesis, a comment on pubertal development as part of reproductive development and a comment on how to account for combined exposures in epidemiological research.

关键词： endocrine disruption male reproduction persistent organic compounds reproductive hormones semen quality

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Gene-environment interaction and male reproductive function

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Asian Journal of Andrology 2010年第3期12卷 298-307,I0007页

作者： Jonatan Axelsson Jens Peter Bonde Yvonne L. Giwercman Lars Rylander Aleksander Giwercman Reproductive Medicine Centre Skane University Hospital Malmo 20502 Sweden Division of Occupational and Environmental Medicine Lund University Lund 22185 Sweden Department of Occupational Medicine Copenhagen University Bispebjerg Hospital Copenhagen NV2400 Denmark Department of Clinical Sctences Malmo Lund University Malmo 20502 Sweden

As genetic factors can hardly explain the changes taking place during short time spans, environmental and lifestyle-related factors have been suggested as the causes of time-related deterioration of male reproductive function. However, considering the strong heterogeneity of male fecundity between and within populations, genetic variants might be important determinants of the individual susceptibility to the adverse effects of environment or lifestyle. Although the possible mechanisms of such interplay in relation to the reproductive system are largely unknown, some recent studies have indicated that specific genotypes may confer a larger risk of male reproductive disorders following certain exposures. This paper presents a critical review of animal and human evidence on how genes may modify environmental effects on male reproductive function. Some examples have been found that support this mechanism, but the number of studies is still limited. This type of interaction studies may improve our understanding of normal physiology and help us to identify the risk factors to male reproductive malfunction. We also shortly discuss other aspects of gene-environment interaction specifically associated with the issue of reproduction, namely environmental and lifestyle factors as the cause of sperm DNA damage. It remains to be investigated to what extent such genetic changes, by natural conception or through the use of assisted reproductive techniques, are transmitted to the next generation, thereby causing increased morbidity in the offspring.

关键词： endocrine disruption gene-environment interaction persistent organic pollutants semen quality testicular cancer

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Proteomics and metabolic phenotyping define principal roles for the aryl hydrocarbon receptor in mouse liver

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Acta Pharmaceutica Sinica B 2021年第12期11卷 3806-3819页

作者： Jian Jin Banrida Wahlang Monika Thapa Kimberly Z.Head Josiah E.Hardesty Sudhir Srivastava Michael L.Merchant Shesh N.Rai Russell A.Prough Matthew C.Cave Department of Pharmacology&Toxicology theUniversity of Louisville School ofMedicineLouisvilleKY 40202USA Department of Endocrinology the Second Affiliated Hospital&Yuying Children’s HospitalWenzhou Medical UniversityWenzhou 325027China Division of Gastroenterology Hepatology&NutritionDepartment of Medicinethe University of Louisville School of MedicineLouisvilleKY 40202USA Superfund Research Center the University of LouisvilleLouisvilleKY 40202USA eDepartment of Biochemistry and Molecular Geneticsthe University of Louisville School of MedicineLouisvilleKY 40202USA Department of Bioinformatics and Biostatistics the School of Public Health and Information Sciencesthe University of LouisvilleLouisvilleKY 40202USA Centre for Agricultural Bioinformatics ICAR-Indian Agricultural Statistics Research InstituteNew Delhi 110012India The Center for Integrative Environmental Health Sciences University of LouisvilleLouisvilleKY 40202USA Division of Nephrology&Hypertension Department of Medicinethe University of Louisville School of MedicineLouisvilleKY 40202USA The Hepatobiology and Toxicology Center University of LouisvilleLouisvilleKY 40202USA Alcohol Research Center University of LouisvilleLouisvilleKY 40202USA Biostatistics and Bioinformatics Facility James Graham Brown Cancer CenterLouisvilleKY 40202USA

Dioxin-like molecules have been associated with endocrine disruption and liver *** better understand aryl hydrocarbon receptor(AHR)biology,metabolic phenotyping and liver proteomics were performed in mice following ligand-activation or whole-body genetic ablation of this *** wild type(WT)and Ahr^(-/-) mice(Taconic)were fed a control diet and exposed to 3,3',4,4',5-pentachlorobiphenyl(PCB126)(61 nmol/kg by gavage)or vehicle for two ***126 increased expression of canonical AHR targets(Cyp1 a1 and Cyp1 a2)in WT but not Ahr^(-/-).Knockouts had increased adiposity with decreased glucose tolerance;smaller livers with increased steatosis and perilipin-2;and paradoxically decreased blood ***126 was associated with increased hepatic triglycerides in Ahr^(-/-).The liver proteome was impacted more so by Ahr^(-/-) genotype than ligandactivation,but top gene ontology(GO)processes were *** PCB126-associated liver proteome was *** principally regulated liver metabolism(e.g.,lipids,xenobiotics,organic acids)and bioenergetics,but it also impacted liver endocrine response(e.g.,the insulin receptor)and function,including the production of steroids,hepatokines,and pheromone binding *** effects could have been indirectly mediated by interacting transcription factors or *** biologic roles of the AHR and its ligands warrant more research in liver metabolic health and disease.

关键词： AHR endocrine disruption Environmental liver disease Nonalcoholic fatty liver disease Perilipin-2 Pheromones PCB126

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Combined Subchronic Toxicity of Bisphenol A and Dibutyl Phthalate on Male Rats

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Biomedical and Environmental Sciences 2013年第1期26卷 63-69页

作者： ZHANG Wen Zhong YONG Ling JIA Xu Dong LI Ning FAN Yong Xiang China National Center for Food Safety Risk Assessment

Objective To evaluate the combined subchronic toxicity of bisphenol A（BPA） and dibutyl phthalate（DBP） in male Sprague Dawley（SD） *** Forty 4‐week‐old male rats weighing 115‐125 g were randomly divided into BPA‐treated,DBP‐treated group,BPA＋DBP‐treated and control groups and fed with a soy‐ and alfalfa‐free diet containing 285.4 ppm BPA,285.4 ppm DBP,285.4 ppm BPA plus 285.4 ppm DBP,and a control diet,respectively,for 90 consecutive *** the end of the study,the animals were sacrificed by exsanguination via the carotid artery under diethyl etherane aesthesia and ***,including liver,kidneys,spleen,thymus,heart,brain,and testis underwent pathological *** androgen receptor（AR）,gonadotropin‐releasing hormone receptor（GNRHR）,and progesterone hormone receptor（PR） genes from the hypothalamus were detected by real‐time *** biomedical parameters were *** No significant difference was found in food intake,body weight,tissue weight,organ/brain weight ratio,and biomedical parameters among the four groups（P〉0.05）.However,BPA and DBP up‐regulated AR,PR and GNRHR expression levels in rats and showed a synergistic or an additive effect in the BPA＋DBP *** The combined subchronic toxicity of BPA and DBP is synergistic or additive in male SD rats.

关键词： Bisphenol A Dibutyl phthalate Combined subchronic toxicity Sprague dawley rat endocrine disruption

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