Combined Subchronic Toxicity of Bisphenol A and Dibutyl Phthalate on Male Rats

作     者：ZHANG Wen Zhong YONG Ling JIA Xu Dong LI Ning FAN Yong Xiang 

作者机构：China National Center for Food Safety Risk Assessment 

出 版 物：《Biomedical and Environmental Sciences》 (生物医学与环境科学（英文版）)

年 卷 期：2013年第26卷第1期

页      面：63-69页

核心收录：

学科分类：100405[医学-卫生毒理学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 10[医学] 

基　　金：supported by the National Key Technology R&D Program(No.2012BAK01B00) 

主　　题：Bisphenol A Dibutyl phthalate Combined subchronic toxicity Sprague dawley rat Endocrine disruption 

摘      要：Objective To evaluate the combined subchronic toxicity of bisphenol A（BPA） and dibutyl phthalate（DBP） in male Sprague Dawley（SD） *** Forty 4‐week‐old male rats weighing 115‐125 g were randomly divided into BPA‐treated,DBP‐treated group,BPA＋DBP‐treated and control groups and fed with a soy‐ and alfalfa‐free diet containing 285.4 ppm BPA,285.4 ppm DBP,285.4 ppm BPA plus 285.4 ppm DBP,and a control diet,respectively,for 90 consecutive *** the end of the study,the animals were sacrificed by exsanguination via the carotid artery under diethyl etherane aesthesia and ***,including liver,kidneys,spleen,thymus,heart,brain,and testis underwent pathological *** androgen receptor（AR）,gonadotropin‐releasing hormone receptor（GNRHR）,and progesterone hormone receptor（PR） genes from the hypothalamus were detected by real‐time *** biomedical parameters were *** No significant difference was found in food intake,body weight,tissue weight,organ/brain weight ratio,and biomedical parameters among the four groups（P〉0.05）.However,BPA and DBP up‐regulated AR,PR and GNRHR expression levels in rats and showed a synergistic or an additive effect in the BPA＋DBP *** The combined subchronic toxicity of BPA and DBP is synergistic or additive in male SD rats.