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electric stimulation at sciatic nerve evokes long-term potentiation of cornu dorsale medullae spinalis field potential in rats at various developmental phases

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Neural Regeneration Research 2007年第7期2卷 385-389页

作者： Jiang Wu Dan Shu Qisheng Hu Department of Physiology Medical College of Wuhan University Wuhan 430071 Hubei Province China

BACKGROUND： Long-term potentiation of cornu dorsale medullae spinalis field potential in adult rats has already been reported; however, there is lack of correlated researches on naenonate, infant and adult rats which have different responses to pain conduction information.OBJECTIVE： To observe the various effects of electric stimulation at sciatic nerve on long-term potentiation of evoked field potential at superficial layer of cornu dorsale medullae spinalis of rats at various developmental phases and analyze manifestations of pain conduction information at superficial layers （ Ⅰ - Ⅱ）of cornu dorsale medullae spinalis in immature rats.DESIGN： Grouping controlled study.SETTING： Department of Physiology, Medical College of Wuhan University.MATERIALS： The experiment was carried out in the Laboratory of Physiology （provincial laboratory）,Medical College of Wuhan University from March 2006 to May 2007. A total of 27 healthy male Sprague-Dawley （SD） rats, 17- 90 days old, SPF grade, weighing 41 -200 g, were provided by Experimental Animal Center, Medical College of Wuhan University.METHODS： Based on their birthdays, rats were divided into naenonate group （17 - 20 days old, weighing 41-52 g, n =10）, infant group （35 - 50 days old, weighing 87 - 125 g, n =10） and adult group （60 - 90 days old, weighing 180 -200 g, n =7）. Left sciatic nerve was separated and stimulated with single square wave （15 V, 0.5 ms）. Meanwhile, evoked field potential was recorded at superficial layers of lateral T13 - L1 cornu dorsale medullae spinalis and then stimulated with high-frequent and high-intensive tetanizing current （30 -40 V, 0.5 ms, 100 Hz, 1s per bundle, 10s in bundle interval） four times. After the operation, onset of long-term potentiation was observed; meanwhile, amplitude changes and latency of field potential were analyzed.MAIN OUTCOME MEASURES： Amplitude and latency changes of field potential at superficial layers of cornu dorsale medullae spinalis of rats in the thr

关键词： long-term potentiation spinal cord electric stimulation

Clinical observation of physiological and psychological reactions to electric stimulation of the amygdaloid nucleus and the nucleus accumbens in heroin addicts after detoxification

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Chinese Medical Journal 2012年第1期125卷 63-66页

作者： FANG Jun GU Jian-wen YANG Wen-tao QIN Xue-ying HU Yong-hua Department of Epidemiology and Biostatistics School of Public Health Peking University Beijing 100191 China Department of Neurosurgery General Hospital of the Chinese People＇s Liberation Army Chengdu Military District Chengdu 610083 Sichuan China

Background Stereotactic surgery has been used to treat heroin abstinence in China since 2000 by ablating the amygdaloid nucleus （AMY） and the nucleus accumbens （NAc）,which also provides opportunity to identify the relationship between these nuclei and *** study aimed to explore the physiological and psychological effects of electrically stimulating the AMY and the NAc in herein addicts after detoxification by observing changes of heart rate,arterial pressure and occurrence of euphoria similar to heroin induced *** A total of 70 heroin addicts after detoxification were recruited,and 61 of them were eligible to be given stereotactic surgery for heroin *** operation was carried out after determining the coordinates of all target nucleuses,and stimulation was performed at the AMY and the NAc solely or *** rate,arterial pressure and occurrence of euphoria similar to heroin induced euphoria were recorded and *** The average heat rate was （66±10） beats/min before electric stimulation,and significantly increased to （84±14） beats/min during stimulation,and changed to （73±12） beats/min 10 minutes after *** was a significant elevation of the average arterial pressure from 83 mmHg before stimulation to 98 mmHg during the stimulation,and it then decreased to 90 mmHg after ***-three of the 61 patients showed intense euphoria similar to heroin induced *** largest number （118/186） of euphoric responses occurred when the AMY and the NAc were stimulated at the same *** ratio was 5.4 （95% CI： 2.4-11.9,P 〈0.0001） to quantify the *** from a Logistic regression model showed a positive correlation between unilateral stimulation of either the AMY or NAC and induction of euphoria （OR 〉1 ）,especially when the left AMY or left NAc was stimulated （P 〈0.05）.Conclusions Our data are consistent with existing results that the AMY and the NAc are related to *** roles i

关键词： the amygdaloid nucleus the nucleus accumbens heroin dependence electric stimulation

A Comparative Study of the Effects of Magnetic stimulation and electric stimulation on Peripheral Nerve Injury in Rat

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2001年第2期21卷 159-162页

作者：郭铁成欧阳兴飚胡道松林传友曹福元邓云平郭正成 Department of Orthopedic Surgery Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Department of Rehabilitation Medicine Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Department of Neurology Research Center of Ex perimental Medicine Tongji Hospital Huazhong University of Science and Technology Wuhan

The influence of pulsed magnetic stimulation on the sciatic nerve injury was investigated. Thirty rats were divided into three groups equally: MS group , electric stimulation group and the control group . The MS and ES were applied immediately after the first 10 min of the sciatic nerve crush. Sciatic function index , toe spreading reflex , muscular weight and volume were measured after the experiment. The TSR of in the groups A and B occurred at 4th day while in the control group it occurs at 10th day. There was statistically significant difference in SFI between groups A and B . The weight and volume of the gastrocnemius muscle were statistically greater in the groups A and B than in the control group . The effect of MS was similar to that of ES. It was suggested that the application of MS immediately after the nerve injury might have an important clinical value as it can accelerate functional recovery and prevent or minimize muscle atrophy. The technique is easily to operate, non invasion, painless and permits tolerance of high intensity output to be used.

关键词： magnetic stimulation electric stimulation sciatic nerve injury

Effect of extracranial electric stimulation at cerebellar fastigial nucleus on serum C-reactive protein of patients with acute cerebral infarction

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Neural Regeneration Research 2007年第7期2卷 425-428页

作者： XuanWang Department of Neurology Second People＇s Hospital of Xinxiang Xinxiang 453002 Henan Province China

BACKGROUND： Some reports indicate that electric and/or chemical stimulation at various brain sites of experimental animals can raise regional cerebral blood flow and improve cerebral circulation; however, its mechanism is still unclear.OBJECTIVE： To observe the effects of electric stimulation at cerebellar fastigial nucleus on serum C-reactive protein of patients with acute cerebral infarction.DESIGN： Non-randomized synchronized contrast study.SETTING： The Second People＇s Hospital of Xinxiang City.PARTICIPANTS： A total of 54 patients with acute cerebral infarction were selected from the Department of Neurology, the Second People＇s Hospital of Xinxiang from December 2005 to December 2006. There were 31 males and 23 females, and their ages ranged from 56 to 80 years. All patients met the diagnostic criteria of the Fourth National Cerebrovascular Academic Meeting, were finally diagnosed by using CT examination,and provided the confirmed consent. Based on therapeutic demands, patients were divided into electric stimulation group and routine treatment group with 27 cases in each group. In addition, 21 healthy subjects,including 11 males and 10 females and aging 53 - 78 years, were selected as the control group. All the subjects in the control group did not have any histories of cerebrovascular diseases and severe body diseases.METHODS： Based on routine drug therapy, patients in the electric stimulation group were also treated by using CVFT-010M cerebral circulation function therapeutic device （made in Shanghai）. Electrode was fixed at bilateral mastoid in the first group and at extensible sides of upper limbs in the second group. electric stimulation was given twice a day and lasted for 30 minutes each time. Ten days were regarded as a *** of device： mode Ⅲ, frequency 198%, and intensity 90% - 110% （bionic current）. Patients in the routine treatment group received the routine drug treatment. Content of serum C-reactive protein was measured in both

关键词： electric stimulation cerebellar nuclei brain infarction C-reactive protein

Web Control System for Transcorneal electric stimulation Devices

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Journal of Biomedical Science and Engineering 2021年第12期14卷 452-459页

作者： Jorge Santiago Amaya Cristhian Alejandro Romero González Kevin Alexis Aguilar Bailon Electronic Engineering Technological Institute of Higher Studies of Chalco (TESCHA) Chalco México Mexiquense Council of Science and Technology (COMECYT) Toluca México

The electrical stimulation systems dedicated to generating unconventional waveforms have been shown to have a positive effect in the treatment of channelopathies, for example, in open-angle glaucoma. However, these signals can be distorted due to different external circumstances, which could lead to counterproductive effects in treatments such as increased intraocular pressure IOP or other effects that are unknown due to poor electrical signaling. In the present work, a web control system capable of communicating with transcorneal electrical stimulation equipment is proposed for the remote control of treatments applied to patients suffering from various ocular channelopathies. As the first phase of this system, it will only focus on treating patients with open-angle glaucoma since this disease is characterized by an increase in IOP and can be immediately measured by an ophthalmologist.

关键词： Mobile App Database Ocular Channelopathies electric stimulation Signal Monitoring Web Control System Intraocular Pressure Mean Square Error

Combinatorial therapies for spinal cord injury repair

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Neural Regeneration Research 2025年第5期20卷 1293-1308页

作者： Carla S.Sousa Andreia Monteiro António J.Salgado Nuno A.Silva Life and Health Sciences Research Institute(ICVS) School of MedicineUniversity of MinhoCampus de Gualtar-gualtarBragaPortugal ICVS/3B’s Associate Lab PT Government Associated LabCampus de Gualtar-gualtarBragaPortugal

Spinal cord injuries have profound detrimental effects on individuals, regardless of whether they are caused by trauma or non-traumatic events. The compromised regeneration of the spinal cord is primarily attributed to damaged neurons, inhibitory molecules, dysfunctional immune response, and glial scarring. Unfortunately, currently, there are no effective treatments available that can fully repair the spinal cord and improve functional outcomes. Nevertheless, numerous pre-clinical approaches have been studied for spinal cord injury recovery, including using biomaterials, cells, drugs, or technological-based strategies. Combinatorial treatments, which target various aspects of spinal cord injury pathophysiology, have been extensively tested in the last decade. These approaches aim to synergistically enhance repair processes by addressing various obstacles faced during spinal cord regeneration. Thus, this review intends to provide scientists and clinicians with an overview of pre-clinical combinatorial approaches that have been developed toward the solution of spinal cord regeneration as well as update the current knowledge about spinal cord injury pathophysiology with an emphasis on the current clinical management.

关键词： electric stimulation neural tissue regeneration neuroprotection polytherapy spinal cord injury

Effects of electric stimulations Applied during Absolute Refractory Period on Cardiac Function of Rabbits with Heart Failure

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2010年第2期30卷 155-158页

作者：张海柱崔长琮胡大一 Department of Cardiology Anyang People's Hospital First Hospital of Xi'an Jiaotong University Department of Cardiology People's Hospital of Peking University

The effects of electric currents applied during absolute refractory period （ARP） on the cardiac function of rabbits with heart failure due to myocardial infarction （MI）, and the safety of this method were investigated. Thirty rabbits were randomly assigned equally to 3 groups： sham-operated group, LV-anterior wall cardiac contractility modulation （LV-CCM） group, and septum-CCM （S-CCM） group. A thoracotomy was performed on all the rabbits. electric pulses were delivered during the ARP on the anterior wall of left ventricle in CCM group and in the septum in S-CCM group, respectively. The left ventricular systolic pressure （LVSP） and maximum positive left ventricular pressure change （＋dp/dtmax）, heart rates, ventricular tachycardia, ventricular fibrillation were observed. It was found that, as compared with the baseline, LVSP, and ＋dp/dtmax were significantly increased, on average, by 15.2% and 19.5% in LV-CCM group （P〈0,05）, and by 8.5% and 10.8% in S-CCM group （P〈0.05）. LVEDP was significantly decreased and -dp/dtmx increased both in LV-CCM group and S-CCM group （P〈0.05）. CCM had no effect on heart rate and induced no arrhythmia in short time. It is concluded that electric currents delivered during the ARP could significantly enhance the contractility of myocardium safely, suggesting that CCM stimulation is a novel potent method for contractility modulation.

关键词： hemodynamics absolute refractory period electric stimulation rabbit

INFLUENCE OF ANTIDROM IC electric STIM ULATI ON ONPREPROTACHYKININ m RNA EXPRESSION IN ADJACENT DORSAL ROOT GANGLIA OF RATS

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Journal of Pharmaceutical Analysis 1999年第2期13卷 97-102页

作者： Li Xiuhua,Zhao Yan,Shi Wenchun,Li XinminFirst Affiliated Hospital,Wang Huisheng Research Center of Neurobiology, Xi′an Medical University, Xi′an 710061 Research Center of Neurobiology Xi'an Medical University Xi'an 710061 China

By in situ hybridization histochemistry, the changes of preprotachykinin (PPT) mRNA expression were examined in the neurons of adjacent thoracal dorsal root ganglion (DRG) after a strong electric stimulation to an intact dorsal cutaneous branch and the cut distal part of left T 9 thoracal spinal nerve of rat. There was a significant increase of the number of neurons expressing PPT mRNA in the ipsilateral T 8, T 9 and T 10 DRG of the animals given electric stimulation to intact spinal nerve branch 24 h after the electric stimulation. The same increase was found in the ipsilateral T 8 and T 10 DRG of the animals given electric stimulation to the distal part of spinal nerve branch. While no change was found in the DRG of the contralateral side of these animals. The present results showed that the antidromic electric stimulation strengthened the biosynthesis of PPT mRNA in adjacent DRG. These findings suggested that there was information transmission across segments between two sensory nerve endings and some bioactive substances such as SP might play important roles in the information transmission across segments of spinal cord.

关键词： preprotachykinin mRNA electric stimulation in situ hybridization histochemistry information transmission across segments dorsal root ganglion rat

Microarray analysis of gene expression after electrical stimulation of the dura mater surrounding the superior sagittal sinus in conscious adult rats

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Chinese Medical Journal 2014年第4期127卷 734-741页

作者： Jiang Lei Dong Zhao Li Fengpeng Liu Ruozhuo Qiu Enchao Wang Xiaolin Yu Shengyuan Department of Neurology Chinese People&#39 s Liberation Army General Hospital Beijing 100853 China

Background The molecular and cellular origins of migraine headache are among the most complex problems in contemporary *** to now the pathogenesis of migraine still remains unclearly *** objective of this study was to explore new factors that may be related to the mechanism of *** The present study performed a comprehensive analysis of gene expression in the trigeminal nucleus caudalis induced by electrical stimulation of dura mater surrounding the superior sagittal sinus in conscious rats using microarray analysis followed by quantitative real-time reverse-transcribed polymerase chain reaction （qRT-PCR） ***＆#39;s two sample t-test was employed when two groups were compared.A P value 〈0.05 was considered to be statistically *** Comparing the placebo and the electrical stimulation groups,40 genes were determined to be significantly differentially *** significantly differentially expressed genes were involved in many pathways,including transporter activity,tryptophan metabolism,G protein signaling,kinase activity,actin binding,signal transducer activity,anion transport,protein folding,enzyme inhibitor activity,coenzyme metabolism,binding,ion transport,cell adhesion,metal ion transport,oxidoreductase activity,mitochondrion function,and *** of the genes were involved in more than 2 *** particular interest is the up-regulation of Phactr3 and Akap5 and the down-regulation of *** These findings may provide important clues for a better understanding of the molecular mechanism of migraine.

关键词： migraine electric stimulation superior sagittal sinus microarray analysis