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drug-eluting beads transarterial chemoembolization sequentially combined with radiofrequency ablation in the treatment of untreated and recurrent hepatocellular carcinoma

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World Journal of Gastrointestinal Surgery 2020年第8期12卷 355-368页

作者： Yan Zhang Mei-Wu Zhang Xiao-Xiang Fan Da-Feng Mao Quan-Hua Ding Lu-Hui Zhuang Shu-Yi Lv Department of Interventional Therapy Hwa Mei HospitalUniversity of Chinese Academy of SciencesNingbo 315010Zhejiang ProvinceChina Ningbo Institute of Life and Health Industry University of Chinese Academy of SciencesNingbo 315010Zhejiang ProvinceChina Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province Ningbo 315010Zhejiang ProvinceChina Department of Gastroenterology Hwa Mei HospitalUniversity of Chinese Academy of SciencesNingbo 315010Zhejiang ProvinceChina

BACKGROUND drug-eluting beads transarterial chemoem-bolization(DEB-TACE)has the advantages of slow and steady release,high local concentration,and low incidence of adverse drug reactions compared to the traditional *** combined with sequentially ultrasound-guided radiofrequency ablation(RFA)therapy has strong anti-cancer effects and little side effects,but there are fewer related long-term studies until *** To explore the outcome of DEB-TACE sequentially combined with RFA for patients with primary hepatocellular carcinoma(HCC).METHODS Seventy-six patients with primary HCC who underwent DEB-TACE sequentially combined with RFA were *** patients with untreated HCC were included in Group A,and 36 patients with recurrent HCC were included in Group *** addition,40 patients with untreated HCC who were treated with hepatectomy were included in Group *** serological examination,preoperative magnetic resonance imaging examination,and post-treatment computed tomography enhanced examination were performed for all *** efficacy was graded as complete remission(CR),partial remission(PR),stable disease and progressive disease at the 3rd,6th,and *** patients were followed up for 3 years and their overall survival(OS),disease-free survival(DFS)were *** The efficacy of Group A and Group C was similar(P>0.05),but the alanine aminotransferase,aspartate aminotransferase and total bilirubin of Group A were lower than those of Group C(all P0.05).The OS rates in Group A and Group B(90%,82.3%,and 66.4%)were simil

关键词： drug-eluting beads transarterial chemoembolization Ultrasound Radiofrequency ablation Hepatocellular carcinoma Untreated Recurrent

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Conventional vs drug-eluting beads transarterial chemoembolization for hepatocellular carcinoma

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World Journal of Hepatology 2017年第18期9卷 808-814页

作者： Jeong Eun Song Do Young Kim Department of Internal Medicine Yonsei University College of MedicineSeoul 120-752South Korea

transarterial chemoembolization(TACE) is the current standard of therapy for patients with intermediatestage hepatocellular carcinoma(HCC) according to the Barcelona Clinic Liver Cancer classification. The concept of conventional TACE(cTACE) is the selective obstruction of tumor-feeding artery by injection of chemotherapeutic agents, leading to ischemic necrosis of the target tumor via cytotoxic and ischemic effects. drugeluting beads(DEBs) have been imposed as novel drugdelivering agents for TACE, which allows for higher concentrations of drugs within the target tumor and lower systemic concentrations compared with cTACE. Despite the theoretical advantages of DEB-TACE, it is still controversial in clinical practice as to whether DEBTACE is superior to cTACE in regard to overall survival and treatment response. In this review article, we summarize the clinical efficacy and safety of DEB-TACE for patients with intermediate or advanced stage HCC in comparison with cTACE.

关键词： Hepatocellular carcinoma drug-eluting beads transarterial chemoembolization transarterial chemoembolization

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