Drug-eluting beads transarterial chemoembolization sequentially combined with radiofrequency ablation in the treatment of untreated and recurrent hepatocellular carcinoma
作者机构：Department of Interventional TherapyHwa Mei HospitalUniversity of Chinese Academy of SciencesNingbo 315010Zhejiang ProvinceChina Ningbo Institute of Life and Health IndustryUniversity of Chinese Academy of SciencesNingbo 315010Zhejiang ProvinceChina Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang ProvinceNingbo 315010Zhejiang ProvinceChina Department of GastroenterologyHwa Mei HospitalUniversity of Chinese Academy of SciencesNingbo 315010Zhejiang ProvinceChina
出 版 物：《World Journal of Gastrointestinal Surgery》 (世界胃肠外科杂志（英文版）（电子版）)
年 卷 期：2020年第12卷第8期
页 面：355-368页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Supported by Medical and Health Science and Technology Foundation of Zhejiang Province,No.2017KY590 and No.2019KY175 and Ningbo Clinical Research Center for Digestive System Tumors,No.2019A21003
主 题：Drug-eluting beads transarterial chemoembolization Ultrasound Radiofrequency ablation Hepatocellular carcinoma Untreated Recurrent
摘 要：BACKGROUND Drug-eluting beads transarterial chemoem-bolization(DEB-TACE)has the advantages of slow and steady release,high local concentration,and low incidence of adverse drug reactions compared to the traditional *** combined with sequentially ultrasound-guided radiofrequency ablation(RFA)therapy has strong anti-cancer effects and little side effects,but there are fewer related long-term studies until *** To explore the outcome of DEB-TACE sequentially combined with RFA for patients with primary hepatocellular carcinoma(HCC).METHODS Seventy-six patients with primary HCC who underwent DEB-TACE sequentially combined with RFA were *** patients with untreated HCC were included in Group A,and 36 patients with recurrent HCC were included in Group *** addition,40 patients with untreated HCC who were treated with hepatectomy were included in Group *** serological examination,preoperative magnetic resonance imaging examination,and post-treatment computed tomography enhanced examination were performed for all *** efficacy was graded as complete remission(CR),partial remission(PR),stable disease and progressive disease at the 3rd,6th,and *** patients were followed up for 3 years and their overall survival(OS),disease-free survival(DFS)were *** The efficacy of Group A and Group C was similar(P0.05),but the alanine aminotransferase,aspartate aminotransferase and total bilirubin of Group A were lower than those of Group C(all P0.05).The OS rates in Group A and Group B(90%,82.3%,and 66.4%)were simil
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