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Cell membrane-derived vesicles for delivery of therapeutic agents

Acta Pharmaceutica Sinica B 2021年第8期11卷 2096-2113页

作者： Quoc-Viet Le Jaiwoo Lee Hobin Lee Gayong Shim Yu-Kyoung Oh College of Pharmacy and Research Institute of Pharmaceutical Sciences Seoul National UniversitySeoul 08826Republic of Korea School of systems Biomedical Science Soongsil UniversitySeoul 06978Republic of Korea

Cell membranes have recently emerged as a new source of materials for molecular delivery *** membranes have been extruded or sonicated to make nanoscale *** synthetic lipid or polymeric nanoparticles,cell membrane-derived vesicles have a unique multicomponent feature,comprising lipids,proteins,and *** cell membrane-derived vesicles contain the intrinsic functionalities and signaling networks of their parent cells,they can overcome various obstacles encountered in ***,the different natural combinations of membranes from various cell sources expand the range of cell membrane-derived vesicles,creating an entirely new category of drug-delivery *** membrane-derived vesicles can carry therapeutic agents within their interior or can coat the surfaces of drug-loaded core *** membranes typically come from single cell sources,including red blood cells,platelets,immune cells,stem cells,and cancer ***,recent studies have reported hybrid sources from two different types of *** review will summarize approaches for manufacturing cell membrane-derived vesicles and treatment applications of various types of cell membrane-derived drug-delivery systems,and discuss challenges and future directions.

关键词： Cell membrane-derived vesicles Membrane engineering drug-delivery systems Blood cells Immune cells Stem cells Cancer cells Manufacturing

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Plant-derived exosome-like nanoparticles and their therapeutic activities

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Asian Journal of Pharmaceutical Sciences 2022年第1期17卷 53-69页

作者： Jisu Kim Shiyi Li Shuya Zhang Jianxin Wang Department of Pharmaceutics School of PharmacyMinistry of EducationFudan University&Key Laboratory of Smart Drug DeliveryShanghai 201203China Institute of Integrated Chinese and Western Medicine Fudan UniversityShanghai 200040China

Nanotechnologies have been successfully applied to the treatment of various ***-derived exosome-like nanoparticles (PENs) are expected to become effective therapeutic modalities for treating disease or in drug-delivery. PENs are minimally cytotoxic to healthy tissues, with which they show excellent biocompatibility, and are biased towards tumors by targeting specific tissues through special endocytosis mechanisms. Thus, the use of these PENs may expand the scope of drug therapies while reducing the off-target *** this review, we summarize the fundamental features and bioactivities of PENs extracted from the grape, grapefruit, ginger, lemon, and broccoli and discuss the applications of these particles as therapeutics and nanocarriers.

关键词： Exosomes Plant-derived exosome-like nanoparticles drug-delivery systems Nanocarriers

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