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Dopamine as a growth differentiation factor in the mammalian brain

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Neural Regeneration Research 2020年第3期15卷 390-393页

作者： Koji Ohira Laboratory of Nutritional Brain Science Department of Food Science and Nutrition Mukogawa Women’s University

The catecholamine,Dopamine,plays an important role in the central nervous system of mammals,including executive functions,motor control,motivation,arousal,reinforcement,and reward.Dysfunctions of the Dopaminergic system lead to diseases of the brains,such as Parkinson’s disease,Tourette’s syndrome,and schizophrenia.In addition to its fundamental role as a neurotransmitter,there is evidence for a role as a growth differentiation factor during development.Recent studies suggest that Dopamine regulates the development ofγ-aminobutyric acidergic interneurons of the cerebral cortex.Moreover,in adult brains,Dopamine increases the production of new neurons in the hippocampus,suggesting the promoting effect of Dopamine on proliferation and differentiation of neural stem cells and progenitor cells in the adult brains.In this mini-review,I center my attention on Dopaminergic functions in the cortical interneurons during development and further discuss cell therapy against neurodegenerative diseases.

关键词： γ-aminobutyric acidergic interneuron adult neurogenesis cerebral cortex Dopamine GABA medial ganglionic eminence migration striatum

Multifunctional Dopamine-assisted preparation of efficient and stable perovskite solar cells

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Journal of Energy Chemistry 2021年第3期30卷 291-300页

作者： Jiankai Zhang Huangzhong Yu School of Physics and Optoelectronics South China University of TechnologyGuangzhou 510640GuangdongChina The Key Laboratory of Functional Molecular Solids Ministry of EducationAnhui Normal UniversityWuhu 241000Anhui China Guangdong Provincial Key Laboratory of New and Renewable Energy Research and Development Guangzhou 510640GuangdongChina South China Institute of Collaborative Innovation Dongguan 523808GuangdongChina

Perovskite solar cells(PSCs)show great potential for next-generation photovoltaics,due to their excellent optical and electrical properties.However,defects existing inside the perovskite film impair both the performance and stability of the device.Uncoordinated Pb^(2+),uncoordinated I^(-),and metallic Pb(Pb^(0))are the main defects occur during perovskite film preparation and device operation,due to the volatilization of organic cationic components.Passivating these defects is a desirable tas k,because they are non-radiative recombination centers that cause open-circuit voltage(VOC)loss and degradation of the perovskite layer.Herein,the multifunctional bioactive compound Dopamine(DA)is introduced for the first time to control the perovskite film formation and passivate the uncoordinated Pb^(2+)defects via Lewis acid-base interactions.The Pb^(0) and I^(-)defects are effectively suppressed by the DA treatment.At the same time,the DA treatment results in a stronger crystal orientation along the(110)plane and upshifts the valence band of perovskite closer to the highest occupied molecular orbital(HOMO)of the hole transport layer(2,2’,7,7’-tetrakis(N,N’-di-pmethoxyphenylamine)-9,9’-spirobifluorene,spiro-OMeTAD),which is beneficial for charge separation and transport processes.Consequently,the stability of MAPbI_(3)(MA=CH_(3)NH_(3))PSCs prepared with the DA additive(especially the thermal stability)is effectively improved due to the better crystallinity and lower number of defect trap states of the perovskite film.The optimized MAPbI3 PSCs maintain approximately 90% of their original power conversion efficiency(PCE)upon annealing at 85℃ for 120 h.The best performance triple-cation perovskite(Cs_(0.05)(FA_(0.83)MA_(0.17))_(0.95)Pb(I_(0.83)Br_(0.17))_(3))(FA=formamidinium)solar cell with ITO/SnO_(2)/Cs_(0.05)(FA_(0.83)MA_(0.17))_(0.95)Pb(I_(0.83)Br_(0.17))_(3):DA/spiro-OMeTAD/MoO_(3)/Ag(ITO=indium tin oxide)structure shows a PCE of 21.03% with negligible hysteresis,which is dramatically enhanced compared to that of the c

关键词： Perovskite solar cell Dopamine Defect Passivation Performance

2D-titanium carbide(MXene)based selective electrochemical sensor for simultaneous detection of ascorbic acid,Dopamine and uric acid

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Journal of Materials Science & Technology 2021年第13期72卷 122-131页

作者： Nagaraj Murugan Rajendran Jerome Murugan Preethika Anandhakumar Sundaramurthy Ashok K.Sundramoorthy Department of Chemistry SRM Institute of Science and TechnologyKattankulathur603203Tamil NaduIndia SRM Research Institute SRM Institute of Science and TechnologyKattankulathur603203Tamil NaduIndia

Two-dimensional(2 D)titanium carbide(MXene)nanosheets exhibited excellent conductivity,flexibility,high volumetric capacity,hydrophilic surface,thermal stability,etc.So,it has been exploited in various applications.Herein,we report synthesis of mixed phase 2 D MXene as a catalytic material for simultaneous detection of important biomolecules such as ascorbic acid(AA),Dopamine(DA)and uric acid(UA).Crystalline structure,surface morphology and elemental composition of mixed phase titanium carbide(Ti-C-T_(x))MXene(T_(x)=-F,-OH,or-O)nanosheets were confirmed by X-ray diffraction(XRD),Raman spectroscopy,high-resolution transmission electron microscopy(HR-TEM),high-re solution scanning electron microscopy(HR-SEM)and Energy-dispersive X-ray spectroscopy(EDS)mapping analysis.Furthermore,Ti-C-T_(x) modified glassy carbon electrode(GCE)was prepared and its electrochemical properties are studied by cyclic voltammetry(CV)and diffe rential pulse voltammetry(DPV).It was found that Ti-C-T_(x) modified GCE(Ti-C-T_(x)/GCE)showed excellent electrocatalytic activity and separated oxidation peaks of important biomolecules such as AA(at 0.01 V),DA(at 0.21 V)and UA(at 0.33 V).Also,Ti-C-T_(x)/GCE sensor is enabled their simultaneous detection in physiological pH from 100 to 1000μM for AA,0.5-50μM for DA and 0.5-4μM&100-1500μM for UA.The limit of detection’s(LOD)was estimated as 4.6μM,0.06μM and 0.075μM for AA,DA and UA,respectively.Moreover,real sample analysis indicated that spiked AA,DA and UA can be determined accurately by Ti-C-T_(x)/GCE with the recovery ratio in the range between 100.5%-103%in human urine samples.The proposed Ti-C-T_(x) modified electrode exhibited good stability,selectivity and reproducibility as an electrochemical sensor for the detection of AA,DA and UA molecules.

关键词： Titanium carbide Dopamine Uric acid Ascorbic acid Electrochemical sensor

Is there a relationship between Dopamine and rhegmatogenous retinal detachment?

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Neural Regeneration Research 2020年第2期15卷 311-314页

作者： Alessio Martucci Massimo Cesareo Maria Dolores Pinazo-Durán Michela Di Pierro Matteo Di Marino Carlo Nucci Massimiliano Coletta Raffaele Mancino Ophthalmology Unit Department of Experimental MedicineUniversity of Rome Tor VergataRomeItaly Ophthalmic Research Unit "Santiago Grisolia"/FISABIO and Cellular-Molecular Ophthalmobiology Group/University of Valencia ValenciaSpain Department of Clinical Sciences and Translational Medicine University of Rome Tor VergataRomeItaly

Dopamine and its receptors have been widely studied in the neurological conditions and in the retina. In this study, we evaluated the possible role of Dopamine in rhegmatogenous retinal detachment(RRD) by comparing the amount of 3,4-dihydroxyphenylacetic acid(DOPAC), a surrogate index of retinal dopamin levels, in the vitreous sample of patients affected by RRD with those affected by macular pucker and vitre ous hemorrhage. Our results showed that significantly higher levels of DOPAC were found in the vitreou sample of patients affected by RRD compared with those affected by vitreous hemorrhage and macula pucker(P = 0.002). Specifically, no trace of the substance was found in vitreous hemorrhage and macula pucker samples. A slightly significant positive correlation was found among DOPAC and post-operativ best corrected visual acuity(r = 0.470, P = 0.049). No correlation was found between DOPAC and the day elapsed between diagnosis and surgery(P = 0.317). For the first time our findings suggest that DOPAC i released in RRD, but not in other retinal diseases such as vitreous hemorrhage and macular pucker. More over, we showed a correlation between visual acuity outcome and the amount of DOPAC in the vitreous This might have a potential, although still unknown, implication in the pathogenesis of the disease and/o in the associated photoreceptors loss. This study was approved by the Ethics Committee of Rome Tor Ver gata University Hospital(R.S.92.10) on September 24, 2010.

关键词： 3,4-dihydroxyphenylacetic acid DOPAC Dopamine Dopaminergic amacrine cells Dopaminergic neurotoxicity macular pucker oxidative stress photoreceptor degeneration rhegmatogenous retinal detachment vitreous hemorrhage

Increased Dopamine and its receptor Dopamine receptor D1 promote tumor growth in human hepatocellular carcinoma

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Cancer Communications 2020年第12期40卷 694-710页

作者： Yan Yan Jiahao Pan Yonghua Chen Wei Xing Qiang Li Dongyin Wang Xiaoshuang Zhou Jingdun Xie Changhong Miao Yunfei Yuan Weian Zeng Dongtai Chen Department of Anesthesiology Sun Yat-Sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdong 510060P.R.China Department of Anesthesiology Huizhou Municipal Central HospitalHuizhouGuangdong 516001P.R.China Department of Anesthesiology Peking University Shenzhen HospitalShenzhenGuangdong 518000P.R.China Department of Anesthesiology Fudan University Zhongshan HospitalShanghai 20032P.R.China Department of Hepatobiliary Oncology Sun Yat-Sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdong 510060P.R.China

Background:Dopamine and Dopamine receptor D1(DRD1),a member of the Dopamine receptor family,have been indicated to play important roles in cancer progression,but Dopamine secretion in hepatocellular carcinoma(HCC)and the effects of DRD1 on HCC remain unclear.This study was designed to explore the contribution of the Dopaminergic system to HCC and determine the relationship between DRD1 and prognosis in HCC patients.Methods:The Dopamine metabolic system was monitored using enzyme-linked immunosorbent assays(ELISAs).The expression of DRD1 was detected by microarray analysis,immunohistochemistry(IHC),and quantitative real-time PCR(qRT-PCR).Stable DRD1 knockout and overexpression cell lines were established for investigation.Transwell,colony formation,and Cell Counting Kit 8(CCK8)assays were performed to assess the malignant behaviors of cancer cells.The cAMP/PI3K/AKT/cAMP response element-binding(CREB)signaling pathway was evaluated by Western blot.This pathway,which is agitated by DRD1 in striatal neurons,had been proven to participate in tumor progression.Xenograft HCC tumors were generated for in vivo experiments.Results:Dopamine secretion increased locally in HCC due to an imbalance in Dopamine metabolism,including the upregulation of dopa decarboxylase(DDC)and the downregulation of monoamine oxidase A(MAOA).Dopamine promoted the proliferation and metastasis of HCC.DRD1 was highly expressed in HCC tissues and positive DRD1 expression was related to a poor prognosis in HCC patients.The upregulation of DRD1 agitated malignant activities,including proliferation and metastasis in HCC by regulating the cAMP/PI3K/AKT/CREB pathway,and the downregulation of DRD1 had opposing effects.The effects of Dopamine on HCC was reversed by depleting DRD1.SCH23390,a selective DRD1 antagonist,inhibited the proliferation and metastasis of HCC cells both in vitro and in vivo.Conclusion:Dopamine secretion was locally increased in HCC and promoted HCC cell proliferation and metastasis.DRD1 was found to exert positive effects on HCC prog

关键词： Dopamine Dopamine receptor D1 hepatocellular carcinoma prognosis target therapy

Dopaminergic-cholinergic imbalance in movement disorders: a role for the novel striatal Dopamine D2-muscarinic acetylcholine M1 receptor heteromer

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Neural Regeneration Research 2021年第7期16卷 1406-1408页

作者： RenéA.J.Crans Francisco Ciruela Laboratory of Toxicology Department of BioanalysisGhent UniversityGhentBelgium Unitat de Farmacologia Departament Patologia i Terapèutica ExperimentalFacultat de Medicina i Ciències de la SalutIDIBELLUniversitat de BarcelonaL’Hospitalet de LlobregatBarcelonaSpain Institut de Neurociències Universitat de BarcelonaBarcelonaSpain

The striatum is the primary input structure of the basal ganglia, which participates in motivational and goaldirected behaviors(Pisani et al., 2007).In physiological conditions, local cholinergic interneurons(ChIs) an... 详细信息

关键词： al. Dopamine Dopamine

Water-selective hybrid membranes with improved interfacial compatibility from mussel-inspired Dopamine-modified alginate and covalent organic frameworks

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Chinese Journal of Chemical Engineering 2020年第1期28卷 90-97页

作者： Hao Yang Hong Wu Fusheng Pan Meidi Wang Zhongyi Jiang Qifan Cheng Cheng Huang Key Laboratory for Green Chemical Technology of Ministry of Education School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China Collaborative Innovation Center of Chemical Science and Engineering(Tianjin) Tianjin 300072China Tianjin Key Laboratory of Membrane Science and Desalination Technology Tianjin UniversityTianjin 300072China State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China

Hybrid membranes combining the merits of both polymer matrices and fillers have drawn extensive attention. The rational design of polymer–filler interface in hybrid membranes is vitally important for reducing the occurrence of void defects. Herein, imine-type covalent organic frameworks(COFs) were selected as the fillers due to their totally organic nature and multi-functionalities. Mussel-inspired Dopamine-modified sodium alginate(Alg DA) was synthesized as the polymer matrix. The Dopamine modification significantly improves the Alg DA–COF compatibility,which enhances the COF content up to 50 wt% in the hybrid membranes. The improved interfacial compatibility enhances the membrane separation selectivity. Accordingly, when utilized for dehydration of ethanol/water mixed solution(water concentration of 10 wt%), the hybrid membrane reveals high water concentration of ~98.7 wt% in permeate, and stable permeation flux larger than 1500 g·m-2·h-1. This work might afford useful insights for fabricating hybrid membranes with high separation selectivity by optimizing the polymer–filler interface.

关键词： Alginate Dopamine Covalent organic framework Membrane Pervaporation Interface

Au nanospheres modified boron-doped diamond microelectrode grown via hydrogen plasma etching solid doping source for Dopamine detection

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Journal of Materials Science & Technology 2020年第14期47卷 42-46页

作者： Kaili Yao Xiaojun Tan Bing Dai Jie Bai Qiaoyang Sun Wenxin Cao Jiwen Zhao Lei Yang Jiecai Han Jiaqi Zhu National Key Laboratory of Science and Technology on Advanced Composites in Special Environments Harbin Institute of TechnologyHarbin150080China

Boron doped diamond(BDD)electrode is a promising electrochemical material for detecting Dopamine level in the human’s body.In this work,we developed a new doping source-graphite and solid boron oxide powders to synthesize BDD film with microwave plasma chemical vapor deposition,so as to avoid using toxic or corrosive dopants,such as boroethane and trimethylborate.The synthesized BDD film is pinhole free and with high doping density of 8.44×10^20 cm^-3 calculated from the Raman spectroscopy.Subsequently,Au nanospheres were decorated on the surface of BDD film to improve electrochemical performance of the BDD film.The Au nanoparticles modified BDD electrode demonstrates an excellent electrochemical response,a high sensitivity(in the range of 5μM-1 m M),and a low detection limit(~0.8μM)for detecting Dopamine.

关键词： Boron doped diamond Graphite powders Boron oxide powders Optical emission spectroscopy Dopamine

Interaction Between Variations in Dopamine D2 and Serotonin 2A Receptor is Associated with Short-Term Response to Antipsychotics in Schizophrenia

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Neuroscience Bulletin 2019年第6期35卷 1102-1105页

作者： Liansheng Zhao Huijuan Wang Yamin Zhang Jinxue Wei Peiyan Ni Hongyan Ren Gang Li Qiang Wang Gavin P Reynolds Weihua Yue Wei Deng Hao Yan Liwen Tan Qi Chen Guigang Yang Tianlan Lu Lifang Wang Fuquan Zhang Jianli Yang Keqing Li Luxian Lv Qingrong Tan Yinfei Li Hua Yu Hongyan Zhang Xin Ma Fude Yang Lingjiang Li Chuanyue Wang Huiyao Wang Xiaojing Li Wanjun Guo Xun Hu Yang Tian Xiaohong Ma Jeremy Coid Dai Zhang Chao Chen Tao Li Chinese Antipsychotics Pharmacogenomics Consortium Psychiatric Laboratory and Mental Health Center the State Key Laboratory of BiotherapyWest China Hospital of Sichuan UniversityChengdu 610041China West China Brain Research Center West China Hospital of Sichuan UniversityChengdu 610041China The National Engineering Research Center for Miniaturized Detection Systems College of Life ScienceNorthwest UniversityXi'an 710069China Shaanxi Lifegen Co. LtdXi'an 712000China Biomolecular Science Research Centre Sheffield Hallam UniversitySheffield S11WBUK Peking University Sixth Hospital(Institute of Mental Health) Beijing 100083China National Clinical Research Center for Mental Disorders and Key Laboratory of Mental Health Ministry of Health(Peking University)Beijing 100871China Second Xiangya Hospital Central South UniversityChangsha 410011China Beijing Anding Hospital Beijing Institute for Brain DisordersCapital Medical UniversityBeijing 100088China Beijing HuiLongGuan Hospital Beijing 102200China Wuxi Mental Health Center Nanjing Medical UniversityWuxi 214121China Institute of Mental Health Tianjin Anding HospitalTianjin 300222China Tianjin Medical University General Hospital Tianjin Medical UniversityTianjin 300052China Hebei Mental Health Center Baoding 071000China Second Affiliated Hospital of Xinxiang Medical University Xinxiang 453003China Department of Psychiatry Xijing HospitalFourth Military Medical UniversityXi'an 710032China Huaxi Biobank West China Hospital of Sichuan UniversityChengdu 610041China 不详

Dear Editor,Schizophrenia is a chronic and debilitating brain disorder,which has a strong genetic component with heritability ranging from 66%to 85%[1,2].Currently,antipsychotic drugs remain the most effective treatment for the psychotic symptoms of schizophrenia[3].Because of the severe sideeffects of first-generation antipsychotics(FGAs),secondgeneration antipsychotics(SGAs)have become more widely used in the treatment of schizophrenia.

关键词： drugs Dopamine Schizophrenia