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Dietary dimethylglycine sodium salt supplementation alleviates redox status imbalance and intestinal dysfunction in weaned piglets with intrauterine growth restriction

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Animal Nutrition 2022年第3期10卷 188-197页

作者： Kaiwen Bai Luyi Jiang Qiming Li Jingfei Zhang Lili Zhang Tian Wang College of Animal Science and Technology Nanjing Agricultural UniversityNanjingChina College of Animal Science Zhejiang UniversityHangzhouChina

There are few studies on the mechanism of redox status imbalance and intestinal dysfunction in intrauterine growth restricted(IUGR)newborn ***,we investigated the mechanism of jejunum dysfunction in weaned piglets with IUGR and the mechanism through which dimethylglycine sodium salt(DMG-Na)supplementation improving the imbalance of their redox *** this work,a total of 10 normal birth weight(NBW)newborn piglets and 20 IUGR newborn piglets were *** weaning at 21 d,they were assigned to 3 groups(n=10/group):NBW weaned piglets fed standard basal diets(NBWC);one IUGR weaned piglets fed standard basal diets(IUGRC);another IUGR weaned piglets from the same litter fed standard basal diets plus 0.1%DMG-Na(IUGRD).The piglets in these 3 groups were sacrificed at 49 d of age,and the blood and jejunum samples were collected *** growth performance values in the IUGRC group were lower(P<0.05)than those in the NBWC *** histomorphological parameters,inflammatory cytokines,and digestive enzyme activity as well as serum immunoglobulin were lower(P<0.05)in the IUGRC group than those in the NBWC *** with these in the NBWC group,the redox status of serum,jejunum,and mitochondria and the expression levels of jejunum redox status-related,cell adhesion-related,and mitochondrial function-related genes and proteins were suppressed in the IUGRC group(P<0.05).However,compared with those in the IUGRC group,the growth performance values,jejunum histomorphological parameters,inflammatory cytokines,digestive enzyme activity,serum immunoglobulin,redox status of serum,jejunum,and mitochondria,and the expression levels of jejunum redox status-related,cell adhesion-related,and mitochondrial function-related genes and proteins were improved(P<0.05)in the IUGRD *** conclusion,dietary DMG-Na supplementation alleviates redox status imbalance and intestinal dysfunction in IUGR weaned piglets mainly by activating the sirtuin 1(SIRT1)/peroxisome

关键词： Intrauterine growth restriction Weaned piglet Jejunum Redox status Mitochondrial function dimethylglycine sodium salt

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Treatment of immune dysfunction in intrauterine growth restriction piglets via supplementation with dimethylglycine sodium salt during the suckling period

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Animal Nutrition 2022年第4期11卷 215-227页

作者： Kaiwen Bai Luyi Jiang Tian Wang Wei Wang School of Biological and Chemical Engineering Zhejiang University of Science and TechnologyHangzhouChina Institute of Dairy Science Ministry of Education Key Laboratory of Molecular Animal NutritionCollege of Animal SciencesZhejiang UniversityHangzhouChina College of Animal Science and Technology Nanjing Agricultural UniversityNanjingChina

This study aimed to investigate the mechanism of small intestinal immune dysfunction in intrauterine growth restriction(IUGR)newborn piglets and relieve this dysfunction via dimethylglycine sodium salt(DMG-Na)supplementation during the suckling *** sows(Duroc×[Landrace×Yorkshire])were selected,and 1 male newborn piglet with normal birth weight(NBW)and 1 male newborn piglet with IUGR were obtained from each *** them,10 NBW and 10 IUGR newborns were euthanized without *** other 20 NBW newborns were allocated to the group named NCON,which means NBW newborns fed a basic milk diet(BMD)(n=10),and the group named ND,which means NBW newborns fed BMD supplemented with 0.1%DMG-Na(n=10);the other 20 IUGR newborns were assigned to the group named ICON,which means IUGR newborns fed BMD(n=10),and the group named ID,which means IUGR newborns fed BMD supplemented with 0.1%DMG-Na(n=10).The newborns were fed BMD from 7 to 21 d of age and euthanized at 21 d of age to collect serum and small intestinal *** growth performance,small intestinal histological morphology and sub-organelle ultrastructure,serum immunoglobulin,small intestinal digestive enzyme activity,inflammatory cytokine level,and jejunum mRNA and protein expression of the toll-like receptor 4(TLR4)/nucleotide-binding oligomerization domain protein(NOD)/nuclear factor-k B(NF-k B)network deteriorated in the ICON group compared to that in the NCON *** small intestinal histological morphology and suborganelle ultrastructure,serum immunoglobulin,small intestinal digestive enzyme activity,and inflammatory cytokine level improved(P<0.05)in the ID group compared to those in the ICON *** jejunum mRNA and protein expression of the TLR4/NOD/NF-k B network improved(P<0.05)in the ID group compared to that in the ICON *** conclusion,the activity of the TLR4/NOD/NF-k B pathway was inhibited in the IUGR newborns,which in turn led to their jejunum immune dysfunction and reduced their perform

关键词： Intrauterine growth restriction Piglet Small intestine Immune dysfunction dimethylglycine sodium salt

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维普期刊数据库

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Supplementation with dimethylglycine sodium salt improves lipid metabolism disorder in intrauterine growth-retarded pigs

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Animal Nutrition 2024年第3期18卷 191-202页

作者： Kaiwen Bai Luyi Jiang Tian Wang School of Biological and Chemical Engineering Zhejiang University of Science and TechnologyHangzhou 310023China College of Animal Science and Technology Nanjing Agricultural UniversityNanjing 210095China College of Biology and Environmental Engineering Zhejiang Shuren UniversityHangzhou 310023China Institute of Dairy Science Ministry of Education Key Laboratory of Molecular Animal NutritionCollege of Animal SciencesZhejiang UniversityHangzhou 310023China

This study aims to elucidate the mechanism of lipid metabolism disorder in intrauterine growth retardation(IUGR)pigs and the potential alleviating effects of dimethylglycine sodium salt(DMG-Na).A total of 60 male newborn piglets were selected for this *** each litter,one normal birth weight(NBW)male piglet(1.53±0.04 kg)and two IUGR male piglets(0.76±0.06 kg)were chosen based on their birth *** piglets were divided into three groups for the study:NBW pigs received a PBS gavage and a common basal diet(NBW-C group),IUGR pigs received the same PBS gavage and common basal diet(IUGR-C group),and IUGR pigs received a 70-mg DMG-Na gavage along with a common basal diet supplemented with 0.1%DMG-Na(IUGR-D group).At 150 d of age,all piglets underwent euthanasia by exsanguination following electrical stunning,after which plasma,liver,and longissimus dorsi(LM)samples were promptly *** IUGR-D group demonstrated improvements in plasma parameters(P<0.05),with lower triglyceride and free fatty acid(FFA)values,and hormone levels(P<0.05),with lower growth hormone,insulin,and homeostasis model assessment of insulin resistance *** of lipid metabolism was observed(P<0.05),with lower triglyceride and FFA,and higher hepatic lipase and total lipase values in the liver,and lower triglyceride and FFA values in the *** ETC complexes showed increased levels(P<0.05),including higher complex III values in the liver,and higher complex I,complex III,and complex V values in the *** levels of energy metabolites were noted(P<0.05),with higher NAD^(+),NAD^(+)/NADH,adenosine triphosphate,and mtDNA values,and lower NADH values in the liver and ***,meat quality parameters showed improvement(P<0.05),with higher pH 24 h and a^(*)values,and lower drip loss 48 h,L^(*),and b^(*)*** expressions of lipid metabolism and mitochondrial function-related genes and proteins were upregulated(P<0.05)compared to the IUGR-C *** conclusio

关键词： Intrauterine growth retardation Pig Lipid metabolism Mitochondrial function dimethylglycine sodium salt

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