Dietary dimethylglycine sodium salt supplementation alleviates redox status imbalance and intestinal dysfunction in weaned piglets with intrauterine growth restriction

作     者：Kaiwen Bai Luyi Jiang Qiming Li Jingfei Zhang Lili Zhang Tian Wang Kaiwen Bai;Luyi Jiang;Qiming Li;Jingfei Zhang;Lili Zhang;Tian Wang

作者机构：College of Animal Science and TechnologyNanjing Agricultural UniversityNanjingChina College of Animal ScienceZhejiang UniversityHangzhouChina 

出 版 物：《Animal Nutrition》 (动物营养（英文版）)

年 卷 期：2022年第10卷第3期

页      面：188-197页

核心收录：

学科分类：090502[农学-动物营养与饲料科学] 0905[农学-畜牧学] 09[农学] 

基　　金：National Key Research and Development Program of China(No.2018YFD0501101) the National Natural Science Foundation of China(No.31802094) 

主　　题：Intrauterine growth restriction Weaned piglet Jejunum Redox status Mitochondrial function Dimethylglycine sodium salt 

摘      要：There are few studies on the mechanism of redox status imbalance and intestinal dysfunction in intrauterine growth restricted(IUGR)newborn ***,we investigated the mechanism of jejunum dysfunction in weaned piglets with IUGR and the mechanism through which dimethylglycine sodium salt(DMG-Na)supplementation improving the imbalance of their redox *** this work,a total of 10 normal birth weight(NBW)newborn piglets and 20 IUGR newborn piglets were *** weaning at 21 d,they were assigned to 3 groups(n=10/group):NBW weaned piglets fed standard basal diets(NBWC);one IUGR weaned piglets fed standard basal diets(IUGRC);another IUGR weaned piglets from the same litter fed standard basal diets plus 0.1%DMG-Na(IUGRD).The piglets in these 3 groups were sacrificed at 49 d of age,and the blood and jejunum samples were collected *** growth performance values in the IUGRC group were lower(P0.05)than those in the NBWC *** histomorphological parameters,inflammatory cytokines,and digestive enzyme activity as well as serum immunoglobulin were lower(P0.05)in the IUGRC group than those in the NBWC *** with these in the NBWC group,the redox status of serum,jejunum,and mitochondria and the expression levels of jejunum redox status-related,cell adhesion-related,and mitochondrial function-related genes and proteins were suppressed in the IUGRC group(P0.05).However,compared with those in the IUGRC group,the growth performance values,jejunum histomorphological parameters,inflammatory cytokines,digestive enzyme activity,serum immunoglobulin,redox status of serum,jejunum,and mitochondria,and the expression levels of jejunum redox status-related,cell adhesion-related,and mitochondrial function-related genes and proteins were improved(P0.05)in the IUGRD *** conclusion,dietary DMG-Na supplementation alleviates redox status imbalance and intestinal dysfunction in IUGR weaned piglets mainly by activating the sirtuin 1(SIRT1)/peroxisome