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Evaluating transcatheter arterial chemoembolization for primary hepatic cancer by magnetic resonance diffusion-weighted imaging

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Chinese Medical Journal 2008年第22期121卷 2353-2356页

作者： FAN Wei-jun ZHANG Liang OUYANG Yu-shu WANG Li-gang WU Pei-hong State Key Laboratory of Oncology in South China Guangzhou Guangdong 510060 China Medical imaging and Interventional Center Cancer Center Sun Yat-Sen University Guangzhou Guangdong 510060 China

Hepatic cancer is associated with very high mortality and morbidity, and the world＇s highest morbidity and mortality rates for this malignant tumor are found in China. Each year, the number of people who die of hepatic cancer in China amounts for 53% of the world total. Although resection is the first-choice treatment for hepatic cancer, only 20%-30% of patients have the opportunity to undergo resection. Transcatheter arterial chemoembolization （TACE） is a typical intervention therapy. Its advantages include minimal trauma, precise efficacy,

关键词： diffusion magnetic resonance imaging chemoembolization hepatocellular carcinoma

Value of multiple models of diffusion-weighted imaging to predict hepatic lymph node metastases in colorectal liver metastases patients

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World Journal of Gastroenterology 2024年第4期30卷 308-317页

作者： Hai-Bin Zhu Bo Zhao Xiao-Ting Li Xiao-Yan Zhang Qian Yao Ying-Shi Sun Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of RadiologyPeking University Cancer Hospital and InstituteBeijing 100142China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of PathologyPeking University Cancer Hospital and InstituteBeijing 100142China

BACKGROUND About 10%-31% of colorectal liver metastases(CRLM)patients would concomitantly show hepatic lymph node metastases(LNM),which was considered as sign of poor biological behavior and a relative contraindication for liver *** to now,there’s still lack of reliable preoperative methods to assess the status of hepatic lymph nodes in patients with CRLM,except for pathology examination of lymph node after *** To compare the ability of mono-exponential,bi-exponential,and stretchedexponential diffusion-weighted imaging(DWI)models in distinguishing between benign and malignant hepatic lymph nodes in patients with CRLM who received neoadjuvant chemotherapy prior to *** In this retrospective study,97 CRLM patients with pathologically confirmed hepatic lymph node status underwent magnetic resonance imaging,including DWI with ten b values before and after *** parameters,such as the apparent diffusion coefficient from the mono-exponential model,and the true diffusion coefficient,the pseudo-diffusion coefficient,and the perfusion fraction derived from the intravoxel incoherent motion model,along with distributed diffusion coefficient(DDC)andαfrom the stretched-exponential model(SEM),were *** parameters before and after chemotherapy were compared between positive and negative hepatic lymph node groups.A nomogram was constructed to predict the hepatic lymph node *** reliability and agreement of the measurements were assessed using the coefficient of variation and intraclass correlation *** Multivariate analysis revealed that the pre-treatment DDC value and the short diameter of the largest lymph node after treatment were independent predictors of metastatic hepatic lymph nodes.A nomogram combining these two factors demonstrated excellent performance in distinguishing between benign and malignant lymph nodes in CRLM patients,with an area under the curve of ***,parameters from SEM sho

关键词： Colorectal cancer Individualized treatment diffusion magnetic resonance imaging Intravoxel incoherent motion Liver

Value of diffusion-weighted imaging in distinguishing pancreatic carcinoma from mass-forming chronic pancreatitis： a meta-analysis

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Chinese Medical Journal 2014年第19期127卷 3477-3482页

作者： Niu Xiangke Sushant Kumar Das Anup Bhetuwal Xiao Yingquan Sun Feng Zeng Lichuan Wang Wenxuan Yang Hanfeng Yang Hanyu Department of Radiology Affiliated Hospital of Chengdu UniversityChengdu Sichuan 610081 China Sichuan Key Laboratory of Medical imaging and Department ofRadiology Affiliated Hospital of North Sichuan Medical CollegeNanchong Sichuan 637000 China Department of Oncology Sixth People's Hospital of ChengduChengdu Sichuan 610000 China

Background Several previous studies have shown that diffusion-weighted imaging （DWl） can provide additional information for focal pancreatic lesions by demonstrating more restricted diffusion in solid malignant tumors than in chronic pancreatitis, which can be indicated by a decreased apparent diffusion coefficient （ADC）. However, these studies have a modest sample size and convey inconclusive results. The aim of this study was to determine, in a meta-analysis, the diagnostic performance of quantitative diffusion-weighted magnetic resonance imaging in distinguishing pancreatic carcinoma from mass-forming chronic pancreatitis. Methods We determined the sensitivities and specificities across studies. A summary receiver operator characteristic （sROC） curve was constructed to calculate the area under the curve （AUC）. Results The pooled sensitivity of DWI was 0.86 （95% Cl： 0.80-0.91） and the pooled specificity was 0.82 （95% CI： 0.72- 0.89）. The AUC of the sROC was 0.91 （95% CI： 0.88-0.93）. Conclusions DWl may be a potentially technically feasible tool for differentiating pancreatic carcinoma from mass- forming chronic pancreatitis. However, large-scale randomized control trials are necessary to assess its clinical value.

关键词： diffusion magnetic resonance imaging meta-analysis carcinoma pancreatic ductal pancreatitis chronic

Neurite Orientation Dispersion and Density imaging of Rat Brain Microstructural Changes due to Middle Cerebral Artery Occlusion at a 3T MRI

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Current Medical Science 2021年第1期41卷 167-172页

作者： Zhen-xiong WANG Wen-zhen ZHU Shun ZHANG Mehran Shaghaghi Ke-jia CAi Department of Radiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Radiology Department of Bioengineeringand the Center for MR ResearchUniversity of Illinois at ChicagoChicago60612USA

The purpose of this work was to demonstrate the feasibility of neurite orientation dispersion and density imaging(NODDI)in characterizing the brain tissue microstructural changes of middle cerebral artery occlusion(MCAO)in rats at 3T MRI,and to validate NODDI metrics with histology.A multi-shell diffusion MRI protocol was performed on 11 MCAO rats and 10 control rats at different post-operation time points of 0.5,2,6,12,24 and 72 *** orientation dispersion index(ODI)and intracellular volume fraction(V_(ic))metrics were compared between MCAO group and control *** evolution of NODDI metrics was characterized and validated by *** was consistent with significantly increased ODI and V_(ic)in comparison to control tissues at all time points(P<0.001).Lesion ODI increased gradually from 0.5 to 72 h,while its V_(ic)showed a more complicated and fluctuated *** and V_(ic)were significantly different between hyperacute and acute stroke periods(P<0.001).The NODDI metrics were found to be consistent with the histological *** conclusion,NODDI can reflect microstructural changes of brain tissues in MCAO rats at 3T MRI and the metrics are consistent with *** study helps to prepare NODDI for the diagnosis and management of ischemic stroke in translational research and clinical practice.

关键词： diffusion magnetic resonance imaging neurite orientation dispersion and density imaging middle cerebral artery occlusion model stroke rats

Progress of intravoxel incoherent motion diffusion-weighted imaging in liver diseases

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World Journal of Clinical Cases 2020年第15期8卷 3164-3176页

作者： Yun-Yun Tao Yi Zhou Ran Wang Xue-Qin Gong Jing Zheng Cui Yang Lin Yang Xiao-Ming Zhang Sichuan Key Laboratory of Medical imaging Department of Radiology and Medical Research Center of Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina

Traditional magnetic resonance(MR)diffusion-weighted imaging(DWI)uses a single exponential model to obtain the apparent diffusion coefficient to quantitatively reflect the diffusion motion of water molecules in living tissues,but it is affected by blood *** incoherent motion(IVIM)-DWI utilizes a double-exponential model to obtain information on pure water molecule diffusion and microcirculatory perfusion-related diffusion,which compensates for the insufficiency of traditional *** recent years,research on the application of IVIM-DWI in the diagnosis and treatment of hepatic diseases has gradually increased and has achieved considerable *** study mainly reviews the basic principles of IVIM-DWI and related research progress in the diagnosis and treatment of hepatic diseases.

关键词： magnetic resonance imaging diffusion magnetic resonance imaging Liver diseases Liver cirrhosis Carcinoma Cholangiocarcinoma

Value of intravoxel incoherent motion in detecting and staging liver fibrosis: A meta-analysis

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World Journal of Gastroenterology 2020年第23期26卷 3304-3317页

作者： Zheng Ye Yi Wei Jie Chen Shan Yao Bin Song West China School of Medicine Sichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Radiology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Liver fibrosis(LF) is a common pathological feature of all chronic liver *** the accumulation of extracellular matrix in the fibrotic liver, true molecular water diffusion and perfusion-related diffusion are restricted. Intravoxel incoherent motion(IVIM) can capture the information on tissue diffusivity and microcapillary perfusion separately and reflect the fibrotic severity with diffusion *** To investigate the diagnostic performance of IVIM in detecting and staging LF with histology as a reference *** A comprehensive literature search was conducted to identify studies on the diagnostic accuracy of IVIM for assessment of histologically proven LF. The stages of LF were classified as F0(no fibrosis), F1(portal fibrosis without septa),F2(periportal fibrosis with few septa), F3(septal fibrosis), and F4(cirrhosis)according to histopathological findings. Data were extracted to calculate the pooled sensitivity, specificity, positive and negative likelihood ratios, and diagnostic odds ratio, as well as the area under the summary receiver operating characteristic curve(AUC) in each *** A total of 12 studies with 923 subjects were included in this meta-analysis with 5 studies(n = 465) for LF ≥ F1, 9 studies(n = 757) for LF ≥ F2, 4 studies(n = 413) for LF ≥ F3, and 6 studies(n = 562) for LF = F4. The pooled sensitivity and specificity were estimated to be 0.78(95% confidence interval: 0.73-0.82) and 0.81(0.74-0.86)for LF ≥ F1 detection with IVIM;0.82(0.79-0.86) and 0.80(0.75-0.84) for staging F2 fibrosis;0.85(0.79-0.90) and 0.83(0.77-0.87) for staging F3 fibrosis, and 0.90(0.84-0.94) and 0.75(0.70-0.79) for detecting F4 cirrhosis, respectively. The AUCs for LF≥ F1, F2, F3, F4 detection were 0.862(0.811-0.914), 0.883(0.856-0.909), 0.886(0.865-0.907), and 0.899(0.866-0.932), respectively. Moderate to substantial heterogeneity was observed with inconsistency index(I2) ranging from 0% to 77.9%. No publication bias was dete

关键词： Liver fibrosis Liver cirrhosis Intravoxel incoherent motion diffusion weight imaging diffusion magnetic resonance imaging Meta-analysis

Verifying the hypothesis of disconnection syndrome in patients with conduction aphasia using diffusion tensor imaging

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Neural Regeneration Research 2007年第4期2卷 217-220页

作者： Yanqin Guo Jing Xu Yindong Yang Department of Neurology Hongqi Hospital Affiliated to Mudanjiang Medical College Mudanjiang 157011 Heilongjiang Province China

BACKGROUND： It is thought in disconnection theory that connection of anterior and posterior language function areas, i.e. the lesion of arcuate fasciculus causes conduction aphasia. OBJECTIVE： To verify the theory of disconnection elicited by repetition disorder in patients with conduction aphasia by comparing the characteristics of diffusion tensor imaging between healthy persons and patients with conduction aphasia. DESIGN： Case-control observation. SETTING： Department of Neurology, Hongqi Hospital Affiliated to Mudanjiang Medical College. PARTICIPANTS： Five male patients with cerebral infarction-involved arcuate fasciculus conduction aphasia, averaged （43±2） years, who hospitalized in the Department of Neurology, Hongqi Hospital Affiliated to Mudanjiang Medical College from February 2004 to February 2005 were involved in this experiment. The involved patients were all confirmed as cerebral infarction by skull CT and MRI, and met the diagnosis criteria revised in 1995 4^th Cerebrovascular Conference. They were examined by the method of Aphasia Battery of Chinese （ABC） edited by Surong Gao. The results were poorer than auditory comprehension disproportionately, and consistented with the mode of conduction aphasia. Another 5 male healthy persons, averaged （43 ± 1 ） years, who were physicians receiving further training in the Department of Neurology, Beijing Tiantan Hospital were also involved in this experiment. Informed consents of detected items were obtained from all the subjects. METHODS： All the subjects were performed handedness assessment with assessment criteria of handedness formulated by Department of Neurology, First Hospital Affiliated to Beijing Medical University. Arcuate fasciculus of involved patients and health controls were analyzed with diffusion tensor imaging （DTI） and divided into 3 parts （anterior, middle and posterior segments） for determining FA value （mean value was obtained after three times of measurements）, and a comparison of

关键词： aphasia, conduction diffusion magnetic resonance imaging