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Gastroesophageal signet ring cell carcinoma morbidity and mortality: A retrospective review

World Journal of Gastrointestinal Surgery 2024年第6期16卷 1629-1636页

作者： Megan Grinlinton Chris Furkert Andrew Maurice Neville Angelo Michael Booth Department of General Surgery North Shore HospitalAuckland 0620New Zealand Department of Pathology North Shore HospitalAuckland 0620New Zealand

BACKGROUND Upper gastrointestinal(GI)signet ring cell carcinomas(SRCC)confer a poor *** benefit of operative intervention for this patient group is contro-versial in terms of overall *** To investigate factors relating to survival in patients with upper GI *** A retrospective,tertiary,single-centre review of patients who were diagnosed with oesophageal,gastroesophageal junction and gastric SRCC was *** primary outcome was to compare mortality of patients who underwent operative management with those who had nonoperative ***-dary outcomes included assessing the relationship between demographic and histopathological factors,and *** One hundred and thirty-one patients were *** one-year survival for the operative group was 81%and for the nonoperative group was 19.1%.The five-year survival in the operative group was 28.6%vs 1.5%in the nonoperative *** difference in overall survival between groups was statistically significant(HR 0.19,95%CI(0.13-0.30),P<0.001).There was no difference in survival when ad-justing for age,smoking status or *** multivariate analysis,patients who underwent surgical management,those with a lower stage of disease,and those with a lower Charlson Comorbidity Index(CCI)had significantly improved *** Well-selected patients with upper GI SRCC appear to have reasonable medium-term survival following *** surgery to a carefully selected patient group may improve the outcome for this disease.

关键词： Signet ring cell carcinoma gastric cancer Oesophageal cancer Poorly cohesive gastric cancer diffuse gastric cancer

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Mutational separation and clinical outcomes of TP53 and CDH1 in gastric cancer

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World Journal of Gastrointestinal Surgery 2023年第12期15卷 2855-2865页

作者： He-Li Liu Huan Peng Chang-Hao Huang Hai-Yan Zhou Jie Ge Department of Gastrointestinal Surgery Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina Clinical Nursing Teaching and Research Section Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina Teaching and Research Section of Clinical Nursing Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina Department of Pathology Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina

BACKGROUND gastric cancer(GC)is a deadly tumor with the fifth highest occurrence and highest global mortality *** to its heterogeneity,the underlying mechanism of GC remains unclear,and chemotherapy offers little benefit to *** To investigate the clinical outcomes of TP53 and CDH1 mutations in *** In this study,202 gastric adenocarcinoma tumor tissues and their corresponding normal tissues were collected.A total of 490 genes were identified using target *** t-test and Wilcoxon rank-sum test,somatic mutations,microsatellite instability,and clinical statistics,including overall survival,were detected,compared,and *** The mutation rates of 32 genes,including TP53,SPEN,FAT1,and CDH1 exceeded 10%.TP53 mutations had a slightly lower overall occurrence rate(33%).The TP53 mutation rate was significantly higher in advanced stages(stage Ⅲ/Ⅳ)than that in early stages(stage Ⅰ/Ⅱ)(Pdiffuse ***53 is related to poor prognosis of advanced-stage tumors;nevertheless,CDH1 corresponds to a diffuse type of ***53 is exclusively mutated in CDH1 and is primarily affected by two distinct GC *** Different somatic mutation patterns in TP53 and CDH1 indicate two major mechanisms of GC.

关键词： gastric cancer TP53 mutation CDH1 mutation Clinical outcome Somatic mutation diffuse gastric cancer

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