Gastroesophageal signet ring cell carcinoma morbidity and mortality: A retrospective review
作者机构：Department of General SurgeryNorth Shore HospitalAuckland 0620New Zealand Department of PathologyNorth Shore HospitalAuckland 0620New Zealand
出 版 物：《World Journal of Gastrointestinal Surgery》 (世界胃肠外科杂志（英文版）（电子版）)
年 卷 期：2024年第16卷第6期
页 面：1629-1636页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Signet ring cell carcinoma Gastric cancer Oesophageal cancer Poorly cohesive gastric cancer Diffuse gastric cancer
摘 要：BACKGROUND Upper gastrointestinal(GI)signet ring cell carcinomas(SRCC)confer a poor *** benefit of operative intervention for this patient group is contro-versial in terms of overall *** To investigate factors relating to survival in patients with upper GI *** A retrospective,tertiary,single-centre review of patients who were diagnosed with oesophageal,gastroesophageal junction and gastric SRCC was *** primary outcome was to compare mortality of patients who underwent operative management with those who had nonoperative ***-dary outcomes included assessing the relationship between demographic and histopathological factors,and *** One hundred and thirty-one patients were *** one-year survival for the operative group was 81%and for the nonoperative group was 19.1%.The five-year survival in the operative group was 28.6%vs 1.5%in the nonoperative *** difference in overall survival between groups was statistically significant(HR 0.19,95%CI(0.13-0.30),P0.001).There was no difference in survival when ad-justing for age,smoking status or *** multivariate analysis,patients who underwent surgical management,those with a lower stage of disease,and those with a lower Charlson Comorbidity Index(CCI)had significantly improved *** Well-selected patients with upper GI SRCC appear to have reasonable medium-term survival following *** surgery to a carefully selected patient group may improve the outcome for this disease.
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