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Combined Subchronic Toxicity of Bisphenol A and dibutyl phthalate on Male Rats

Biomedical and Environmental Sciences 2013年第1期26卷 63-69页

作者： ZHANG Wen Zhong YONG Ling JIA Xu Dong LI Ning FAN Yong Xiang China National Center for Food Safety Risk Assessment

Objective To evaluate the combined subchronic toxicity of bisphenol A（BPA） and dibutyl phthalate（DBP） in male Sprague Dawley（SD） *** Forty 4‐week‐old male rats weighing 115‐125 g were randomly divided into BPA‐treated,DBP‐treated group,BPA＋DBP‐treated and control groups and fed with a soy‐ and alfalfa‐free diet containing 285.4 ppm BPA,285.4 ppm DBP,285.4 ppm BPA plus 285.4 ppm DBP,and a control diet,respectively,for 90 consecutive *** the end of the study,the animals were sacrificed by exsanguination via the carotid artery under diethyl etherane aesthesia and ***,including liver,kidneys,spleen,thymus,heart,brain,and testis underwent pathological *** androgen receptor（AR）,gonadotropin‐releasing hormone receptor（GNRHR）,and progesterone hormone receptor（PR） genes from the hypothalamus were detected by real‐time *** biomedical parameters were *** No significant difference was found in food intake,body weight,tissue weight,organ/brain weight ratio,and biomedical parameters among the four groups（P〉0.05）.However,BPA and DBP up‐regulated AR,PR and GNRHR expression levels in rats and showed a synergistic or an additive effect in the BPA＋DBP *** The combined subchronic toxicity of BPA and DBP is synergistic or additive in male SD rats.

关键词： Bisphenol A dibutyl phthalate Combined subchronic toxicity Sprague dawley rat Endocrine disruption

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Uncertainty Evaluation for the Determination of dibutyl phthalate(DBP) Concentration in Liqueur by GC-MS

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Agricultural Science & Technology 2014年第8期15卷 1262-1264页

作者：王彩霞安徽省食品药品检验研究院安徽合肥230051

The dibutyl phthalate （DBP） concentration in liqueur was measured by gas chromatography-mass spectrometry （GC-MS）, and the uncertainty during the mea-surement was evaluated in this study. The results showed that the combined stan-dard uncertainty was determined as 0.028 and the expanded uncertainty was 0.056 at confidence probability p=95%, coverage factor k=2, by fol owing the methods de-scribed in GB/T 21911-2008 ＂Determination of phthalate Esters in Foods＂. The av-erage DBP concentration in the liqueur of eight repeated measurements was（0.985＆#177; 0.056） mg/kg finaly.

关键词： Gas chromatography-mass spectrometry dibutyl phthalate Liqueur Uncertainty

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Food emulsifier glycerin monostearate aggravates phthalates'testicular toxicity by disrupting tight junctions'barrier function in rats

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Food Quality and Safety 2021年第2期5卷 179-187页

作者： Lingzi Xia Min Yang Miao He Mingzhe Jiang Chang Qin Zhijun Wei Haitao Gao Department of Preventive Medicine School of Public Health and ManagementWenzhou Medical UniversityWenzhouChina

Objectives:This study aimed to investigate the effect of the widely used food emulsifier glycerin monostearate(GM)on testicular toxicity caused by the mixture of three commonly used phthalate esters(MPEs)in rats,and further to explore the underlying *** and Methods:Thirty male Sprague-Dawley rats were randomly divided into three *** were orally treated with 160 mg/kg/d MPEs in the MPEs group;coinstantaneously treated with 160 mg/kg/d MPEs and 200 mg/kg/d GM in the MPEs+GM group;and treated with the excipient in the control *** intervention lasted for 5 *** weight,epididymis weight,testicular histopathology,and serum testosterone were detected for testicular toxicity *** testicular ultrastructure,the tight junction proteins zonula occluden(ZO)-1,and claudin were measured for the mechanism ***:The body weight,epididymis,serum testosterone level,and anogenital distance in the MPEs+GM group were significantly decreased compared with control group(P<0.05);Testicular histopathological observation showed that shed spermatids were observed in the MPEs+GM *** observation of testicular cells showed that the cristae number was decreased in some mitochondria in the MPEs group,whereas the cristae were fused and disappeared in most mitochondria in the MPEs+GM *** tight junctions were broken in the MPEs+GM group;meanwhile,the expression of ZO-1 and claudin were altered in the MPEs+GM group(P<0.01).Conclusions:The results from this study indicated that GM aggravated MPEs'testicular toxicity,which might relate to the injured mitochondria and damaged tight junctions in testicular tissue.

关键词： Glycerin monostearate butyl benzyl phthalate dibutyl phthalate di(2-ethylhexyl)phthalate male reproductive toxicity tight junction

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Chemical Constituents of Angelica sinensis

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Journal of Chinese Pharmaceutical Sciences 2004年第1期13卷 1-3页

作者：路新华张金娟梁鸿赵玉英华北制药集团新药开发中心河北石家庄050015 北京大学药学院天然药物学系北京100083

Aim To investigate the active constituents responsible for thepharmacological activities of Angelica sinensis (Oliv) Diels. Methods Chromatography was used toisolate chemical components, and spectroscopy was used to identify their structures. Results Sevencompounds were isolated and their structures were identified as ferulic acid (1), conife-rylferukte(2) , bis (2-ethylhexyl) phthalate (3), dibutyl phthalate (4), lignoceric acid (5), palmitic acid(6), and Z-6, 7-cis-dihydroxyligustilide (7) Conclusion Bis (2-ethylhexyl) phthalate and dibutylphthalate were obtained from Angelica sinensis for the first time.

关键词： angelica sinensis chemical constituents bis (2-ethylhexyl) phthalate dibutyl phthalate

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