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Celiac disease:diagnostic criteria in progress

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Cellular & Molecular Immunology 2011年第2期8卷 96-102页

作者： U Volta V Villanacci Department of Clinical Medicine St Orsola-Malpighi University HospitalBolognaItaly Department of Pathology Spedali CiviliBresciaItaly

Until a few years ago,celiac disease(CD)was thought to be a rare food intolerance that was confined to childhood and characterized by severe malabsorption and flat intestinal ***,CD is regarded as an autoimmune disorder that is common in the general population(affecting 1 in 100 individuals),with possible onset at any age and with many possible *** identification of CD is challenging because it can begin not only with diarrhea and weight loss but also with atypical gastrointestinal(constipation and recurrent abdominal pain)and extra-intestinal symptoms(anemia,raised transaminases,osteoporosis,recurrent miscarriages,aphthous stomatitis and associated autoimmune disorders),or it could be completely *** the last 20 years,the diagnostic accuracy of serology for CD has progressively increased with the development of highly reliable tests,such as the detection of IgA tissue transglutaminase and antiendomysial and IgG antideamidated gliadin peptide *** routine use of antibody markers has allowed researchers to discover a very high number of‘borderline’cases,characterized by positive serology and mild intestinal lesions or normal small intestine architecture,which can be classified as potential ***,it is evident that the‘old celiac disease’with flat mucosa is only a part of the spectrum of *** is possible that serology could identify CD in its early stages,before the appearance of severe intestinal *** cases with a positive serology but with mild or absent intestinal lesions,the detection of HLA-DQ2 and HLA-DQ8 can help reinforce or exclude the diagnosis of gluten sensitivity.

关键词： celiac disease clinical presentation diagnostic criteria histology,genetics serology

Comparison of the prevalence of sarcopenia in geriatric patients in Xining based on three different diagnostic criteria

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World Journal of Clinical Cases 2022年第33期10卷 12200-12207页

作者： Shi-Qin Pan Xiao-Fang Li Ming-Qin Luo Yue-Mei Li Department of Nuring Qinghai Provincial People’s HospitalXining 810000Qinghai ProvinceChina

BACKGROUND Sarcopenia is an age-related decline in skeletal muscle mass,which depends on an assessment of muscle strength and muscle *** diagnostic definition of sarcopenia varies by *** To determine the optimal diagnostic criteria for sarcopenia in a plateau *** off values for the components of diagnostic algorithms for sarcopenia in plateau populations should consider *** One hundred and fifty subjects aged>60 years attending a tertiary comprehensive hospital in the city of Xining(elevation:2260 m)between October and December 2018 were *** strength,muscle mass,and physical performance were *** was diagnosed according to the Asian Working Group for Sarcopenia(AWGS)2019 criteria,Beijing criteria,and Lasha *** Across diagnostic criteria,there were significant differences in the prevalence of sarcopenia in the overall population and stratified by *** prevalence of sarcopenia measured by the AWGS 2019 or Lasha criteria was significantly higher in female compared to male *** males,the prevalence of sarcopenia measured by the Beijing criteria was significantly higher in subjects who identified as Han compared to *** females,there were no significant differences in the prevalence of sarcopenia by ethnicity according to any *** The Lasha criteria provided a lower prevalence of sarcopenia(males,8.7%;females,22.41%;overall,14%)and were able to differentiate between males and *** Lasha criteria are likely most appropriate for detection of sarcopenia in this plateau *** recommend the Lasha criteria for detection of sarcopenia in Xining.

关键词： Ethnic diagnostic criteria Sarcopenia Prevalence Plateau

Comparing the diagnostic criteria of MAFLD and NAFLD in the Chinese Population:A Population-based Prospective Cohort Study

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Journal of Clinical and Translational Hepatology 2022年第1期10卷 6-16页

作者： Cheng Yu Minzhen Wang Shan Zheng Miao Xia Hongyan Yang Desheng Zhang Chun Yin Ning Cheng Yana Bai Department of Epidemiology and Statistics School of Public HealthLanzhou UniversityLanzhouGansuChina Workers’Hospital of Jinchuan Group Co LtdJinchangGansuChina Centre of Medical Laboratory School of Basic Medical ScienceLanzhou UniversityLanzhouGansuChina

Background and Aims:Metabolic dysfunction-associ-ated fatty liver disease(MAFLD)is a new concept,pro-posed in 2020;however,its applicability in Asia populations has yet to be ***,we aimed to compare the difference in epidemiological and clinical characteris-tics between MAFLD and non-alcoholic fatty liver disease(NAFLD)among Asian ***:Based on the Jinchang cohort,30,633 participants were *** prevalence and incidence of MAFLD and NAFLD were used to analyze the epidemic characteristics and its overlapping *** addition,the corresponding clinical character-istics of the two diagnostic criteria populations were ***:The prevalence rates of MAFLD and NAFLD were 21.03%and 18.83%,*** an average 2.28-year follow-up,the incidence densities of MAFLD and NAFLD were 41.58 per 1,000 person-years and 37.69 per 1,000 person-years,*** the increase of baseline age,body mass index(BMI),and waist circumfer-ence(WC)levels,the prevalence and incidence of MAFLD and NAFLD were on the rise(all ptrend<0.05).Among the total patients diagnosed at baseline or follow-up,most pa-tients had both MAFLD and NAFLD,accounting for 78.84%and 82.88%,*** with NAFLD,MAFLD patients had greater proportions of males and metabolic diseases(diabetes,dyslipidemia),and had higher BMI,WC,liver enzymes,blood glucose,and lipid levels in the base-line diagnosis patients(p<0.05).Additionally,lean MAFLD patients had higher metabolic disorders than lean NAFLD patients(p<0.05).Conclusions:Compared with NAFLD,the newly proposed definition of MAFLD is more practical and accurate,and it can help identify more fatty liver pa-tients with high-risk diseases.

关键词： MAFLD NAFLD diagnostic criteria Applicability Prospective cohort study.

diagnostic criteria for autoimmune chronic pancreatitis revisited

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World Journal of Gastroenterology 2006年第16期12卷 2487-2496页

作者： Kyu-Pyo Kim Myung-Hwan Kim Jong Cheol Kim Sang Soo Lee Dong Wan Seo Sung Koo Lee Department of Internal Medicine University of Ulsan College of MedicineAsan Medical CenterSeoulKorea

Autoimmune chronic pancreatitis （AIP） is increasingly being recognized worldwidely, as knowledge of this entity builds up. Above all, AIP is a very attractive disease to clinicians in terms of its dramatic response to the oral steroid therapy in contrast to ordinary chronic pancreatitis. Although many characteristic findings of AIP have been described, definite diagnostic criteria have not been fully established. In the year 2002, the Japan Pancreas Society published the diagnostic criteria of AIP and many clinicians around the world use these criteria for the diagnosis of AIP. The diagnostic criteria proposed by the Japan Pancreas Society, however, are not completely satisfactory and some groups use their own criteria in reporting AIP. This review discusses several potential limitations of current diagnostic criteria for this increasingly recognized condition. The manuscript is organized to emphasize the need for convening a consensus to develop improved diagnostic criteria.

关键词： Autoimmune chronic pancreatitis diagnostic criteria

Proposal of definition and diagnostic criteria for sarcopenic obesity by ESPEN and EASO

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Hepatobiliary Surgery and Nutrition 2023年第3期12卷 431-434页

作者： Toshimi Kaido Department of Gastroenterological and General Surgery St.Luke’s International HospitalTokyoJapan

In the last decade,many investigators including us have reported the negative impact of preoperative sarcopenia or low skeletal muscle mass on outcomes after surgery including hepato-biliary-pancreatic(HBP)surgery such as liver transplantation,liver surgery,biliary surgery,and pancreatic surgery(1-5).In addition to low skeletal muscle mass,the abnormality of body compositions,decreased muscle quality and visceral obesity,has been clarified to be also negatively associated with poor outcomes after HBP surgery(2-5).Consequently,it was easily supposed that co-existence of sarcopenia and obesity,called sarcopenic obesity(SO),had more strong negative impact on ***,not a few studies have demonstrated negative clinical impact of SO on outcomes after HBP surgery using various definitions for SO(6-10).We reported that patients with SO,defined by low skeletal muscle mass with high visceral fat to subcutaneous fat ratio evaluated by preoperative computed tomography(CT)image,had significant worse survival than non-sarcopenia patients and patients with sarcopenia only after liver transplantation,hepatic resection,and pancreatic resection(6-9).

关键词： Sarcopenic obesity(SO) body composition diagnostic criteria

diagnostic criteria for autoimmune pancreatitis in Japan

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World Journal of Gastroenterology 2008年第32期14卷 4992-4994页

作者： Terumi Kamisawa Kazuichi Okazaki Shigeyuki Kawa Department of Internal Medicine Tokyo Metropolitan Komagome Hospital Third Department of Internal Medicine Kansai Medical University Center for Health Safety and Environmental Management Shinshu University

Autoimmune pancreatitis （AIP） is a particular type of pancreatitis of presumed autoimmune etiology. Currently, AIP should be diagnosed based on combination of clinical, serological, morphological, and histopathological features. When diagnosing AIP, it is most important to differentiate it from pancreatic cancer. diagnostic criteria for AIP, proposed by the Japan Pancreas Society in 2002 first in the world, were revised in 2006. The criteria are based on the minimum consensus of AIP and aim to avoid misdiagnosing pancreatic cancer as far as possible, but not for screening AIR The criteria consist of the following radiological, serological, and histopathological items：（1） radiological imaging showing narrowing of the main pancreatic duct and enlargement of the pancreas, which are characteristic of the disease; （2） laboratory data showing abnormally elevated levels of serum y-globulin, IgG or IgG4, or the presence of autoantibodies; （3） histopathological examination of the pancreas demonstrating marked fibrosis and prominent infiltration of lymphocytes and plasma cells, which is called lymphoplasmacytic sclerosing pancreatitis （LPSP）. For a diagnosis of AIP, criterion 1 must be present, together with criterion 2 and/ or criterion 3. However, it is necessary to exclude malignant diseases such as pancreatic or biliary cancer.

关键词： Autoimmune pancreatitis diagnostic criteria IgG4 Lymphoplasmacytic sclerosing pancreatitis

Estimated impact of introduction of new diagnostic criteria for gestational diabetes mellitus

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World Journal of Diabetes 2021年第6期12卷 868-882页

作者： Leon de Wit Anna B Zijlmans Doortje Rademaker Christiana A Naaktgeboren J Hans DeVries Arie Franx Rebecca C Painter Bas B van Rijn Department of Obstetrics and Gynaecology University Medical Center UtrechtUtrecht 3584 EANetherlands Department of Obstetrics and Gynaecology Gelderse Vallei HospitalEde 6716 RPNetherlands Department of Obstetrics and Gynaecology Amsterdam University Medical Centers-Location AMCAmsterdam 1105 AZNetherlands Department of Obstetrics and Gynaecology Amsterdam University Medical Centers–Location AMCAmsterdam 1105 AZNetherlands Department of Endocrinology Amsterdam University Medical Centers–Location AMCAmsterdam 1105 AZNetherlands Department of Obstetrics and Fetal Medicine Erasmus MC Sophia Children HospitalRotterdam 3015 GDNetherlands

BACKGROUND Implementation of new diagnostic criteria for gestational diabetes mellitus(GDM)are still a subject of debate,mostly due to concerns regarding the effects on the number of women diagnosed with GDM and the risk profile of the women newly *** To estimate the impact of the World Health Organization(WHO)2013 criteria compared with the WHO 1999 criteria on the incidence of gestational diabetes mellitus as well as to determine the diagnostic accuracy for detecting adverse pregnancy *** We retrospectively analyzed a single center Dutch cohort of 3338 women undergoing a 75 g oral glucose tolerance test where the WHO 1999 criteria to diagnose GDM were clinically *** were categorized into four groups:non-GDM by both criteria,GDM by WHO 1999 only(excluded from GDM),GDM by WHO 2013 only(newly diagnosed)and GDM by both *** compared maternal characteristics,pregnancy outcomes and likelihood ratios for adverse pregnancy *** Retrospectively applying the WHO 2013 criteria increased the cohort incidence by 13.1%,from 19.3%to 32.4%.Discordant diagnoses occurred in 21.3%;4.1%would no longer be labelled as GDM,and 17.2%were newly *** to the non-GDM group,women newly diagnosed were older,had higher rates of obesity,higher diastolic blood pressure and higher rates of caesarean *** infants were more often delivered preterm,large-for-gestational-age and were at higher risk of a 5 min Apgar scorecriteria would result in a substantial increase in GDM *** diagnosed women are at increased risk for pregnancy adverse *** risk,however,seems to be lower than those identified by the

关键词： diagnostic criteria Gestational diabetes Glucose tolerance test Incidence Pregnancy outcome

Development and Validation of diagnostic criteria for Elderly Atopic Dermatitis

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International Journal of Dermatology and Venereology 2024年第1期7卷 1-5页

作者： Shang-Shang Wang Zheng Li Chao-Ying Gu Hui-Bin Yin Yue-Meng Wu Xu Yao Wei Li Department of Dermatology Shanghai Institute of DermatologyHuashan HospitalFudan UniversityShanghai 200040China Department of Allergy and Rheumatology Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIsHospital for Skin Diseases(Institute of Dermatology)Chinese Academy of Medical Sciences and Peking Union Medical CollegeNanjingJiangsu 210042China

Objective:Elderly atopic dermatitis(AD)is a newly identified subtype of *** specific diagnostic criteria are needed for elderly AD has been *** study aimed to propose diagnostic criteria for elderly AD and evaluate the ***:A hospital-based study was *** screened the clinical features of 1,312 patients with AD of different ages in 1 cohort and proposed a set of diagnostic criteria for elderly *** criteria were then validated in another cohort of 223 patients clinically diagnosed with elderly AD by dermatologists specialized in AD to examine the diagnostic sensitivity compared with other criteria by chi-square ***:Based on the patients’clinical features,a set of diagnostic criteria for elderly AD were *** new diagnostic criteria showed significantly higher sensitivity than the classical diagnostic criteria(Pcriteria,while only 43.5%,65.5%,and 52.0%fulfilled the Hanifin and Rajka criteria,the Japanese Dermatology Academy criteria,and the United Kingdom Working Party criteria,***:The newly proposed criteria for elderly AD yielded high diagnostic sensitivity,particularly for mild and moderate AD.

关键词： atopic dermatitis elderly diagnostic criteria sensitivity clinical features atypical

Comparison between SARS, MERS and COVID-19 in diagnostic criteria

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Medical Theory and Hypothesis 2022年第3期5卷 5-8页

作者： Mohammad Darvishi Mohammad Reza Nazer Fatemeh Hajilou Infectious Diseases and Tropical Medicine Research Center(IDTMRC) Department of Aerospace and Subaquatic MedicineAJA University of Medicinal SciencesTehranIran Department of Infectious Diseases Hepatitis Research CenterLorestan University of Medical SciencesKhorramabadIran Faculty of Pharmacy Tehran Medical SciencesIslamic Azad UniversityTehranIran

Since a lot of people get involved by COVID-19 infection and died and lots of them obliged to stay at home and teleworking due to its unknown contagious pneumonia in February and March 2020 in Iran and the world;and this number is growing,it seems necessary to study the diagnostic criteria of this virus,based on the recently published articles,and then compare them with Severe acute respiratory syndrome(SARS)and Middle East respiratory syndrome(MERS).Corona viruses are the largest known RNA viruses able to infect humans and *** viruses can cause more serious respiratory diseases in elderly,or immunocompromised *** this article,by comparing COVID-19,SARS and MERS viruses,we aim to find similarities and differences between these three which are from the same family and by expressing their diagnostic criteria,help care units to find patients faster and have enough time for treating them.

关键词： novel corona virus COVID-19 SARS MERS diagnostic criteria