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The Effect of Paroxetine on Depressive symptom with Somatic Disease and Change of Platelet 5-HT Concentration

Journal of Huazhong University of Science and Technology(Medical Sciences) 2003年第1期23卷 29-31页

作者：郑凯史庭慧刘晓晴 DepartmentofNeurology TongjiHospitalTongjiMedicalCollegeHuazhongUniversityofScienceandTechnology DepartmentofInternalMedicine TongjiHospitalTongjiMedicalCollegeHuazhongUniversityofScienceandTechnology

To study the effect of paroxetine on Depressive symptom accompanying somatic disease and the value of platelet 5-HT concentration in the diagnosis of depression, 30 patients with Depressive symptom were treated with paroxetine. All patients were evaluated on Zung and HAMD scale and assayed of platelet 5-HT concentration before and after treatment. It was found that patients had a lower level of platelet 5-HT concentration than healthy people (Pdepressive and somatic symptoms were both improved (P0.05). It was suggested that paroxetine was a good antidepressant and platelet 5-HT concentration was useful in the screening of depression.

关键词： paroxetine Depressive symptom 5-HT

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Prevalence and risk factors of cardiovascular diseases and psychological distress among female scientists and technicians

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2022年第12期23卷 1057-1064页

作者： Lijun ZHANG Yanping BAO Guo LI Shuhui TAO Meiyan LIU Department of Psycho-Cardiology Beijing Anzhen HospitalCapital Medical UniversityBejing 100029China National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence Peking UniversityBeijing 100191China School of Public Health Peking UniversityBejing 100191China Henan Medical School Henan UniversityKaifeng 475001China

This study aimed to explore the prevalence and risk factors of cardiovascular disease(CVD)and psychological distress among female scientists and technicians in China.Accordingly,we included scientists and technicians from representative research institutions,medical institutions,colleges,universities,and businesses in China,and the data were collected from July 1,2019 to March 31,2021 via online questionnaires.The parameters evaluated in this study included age,sex,marital status,educational background,monthly income,sleep hours,sleep problems,smoking,alcohol consumption,work-related stress,work burnout,cardiovascular symptoms,CVD,family history,and depressive and anxiety symptoms.A total of 14530 scientists and technicians were included,comprising 7144 men and 7386 women.We found 34.9%men and 16.6%women with CVD,35.1%men and 21.4%women with Depressive symptoms,28.7%men and 13.8%women with anxiety symptoms,and 22.0%men and9.5%women with CVD combined with depressive or anxiety symptoms.This study focused on the details of women.Younger women(age≤35 years)had the highest prevalence of Depressive symptoms(24.9%),anxiety symptoms(16.2%),and comorbidity(11.2%).It was established that,despite traditional risk factors,unmanageable work burnout,Depressive symptoms,and anxiety symptoms were associated with a higher risk of CVD in women;insomnia,overwhelming work stress,unmanageable work burnout,and CVD were linked to a higher risk of Depressive symptoms and anxiety;insomnia,overwhelming work stress,and unmanageable work burnout were related to CVD combined with depressive or anxiety symptoms.A bidirectional relationship was noted between CVD and depression or anxiety in female scientists and technicians,and insomnia and overwhelming work stress were positively associated with comorbidity.It is suggested that effective measures should be taken to protect female scientists and technicians from CVD and psychological distress.

关键词： Female scientist and technician Depressive symptom Anxiety Insomnia Cardiovascular disease(CVD)

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