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Synthesis and Properties of PGS-Li Scaffold

Chemical Research in Chinese Universities 2018年第4期34卷 670-675页

作者： LIU Zhihui LU Yadong FENG Wei YANG Junxing GAO Shang SONG Lijie WANG Yao WANG Bowei Stomatology Hospital of Jilin University Changehun 130012 P. R. China The Seeond Hospital of Jilin University Changehun 130022 P R. China China-Japan Union Hospital of Jilin University Changehun 130033 P. R. China

Lithium ion-doped polyglycerol sebacate scaftbld（PGS）-Li was synthesized by adding lithium ions to po- lyglycerol sebacate（PGS） during its crosslinking process due to the specific effects of lithium ions on periodontal li- gament cells, cementoblasts and the eminent performance of PGS. The molecular mass, composition, structure, porosity, thermal properties, and hydrophilicity of the composite were characterized by gel permeation chromatogra- phy（GPC）, Fourier transform infrared spectroscopy（FTIR）, inductively coupled plasma optical emission spectrome- ter（ICP-OES）, scanning electron microscopy（SEM）, X-ray photoelectron spectroscopy（XPS）, thermogravimetric analyzer（TGA） and contact angle measurments, and the degradation of the material was evaluated by in vitro degra- dation experiments. The biological activity of PGS-Li scaffold was detected by calcein-AM staining and cytotoxicity test. The results indicate that PGS-Li scaffold has been successfully synthesized, which has similar composition and structure to PGS, but slightly larger molecular weight. In addition, the porosity and pore size of PGS-Li scaffold ba- sically meet the requirements of engineering scaffold materials and the seaffold shows better performance in terms of hydrophilicity and thermal stability than PGS. In vitro degradation experimental results show that the degradation rate of PGS-Li scaffold is higher than that of PGS. What＇s more, the results of cytotoxicity test and cell staining show that there is no significant difference in the proliferation and cell morphology of cementoblasts.

关键词： Lithium Polyglycerol sebacate(PGS) Tissue engineering dental cementum

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