Synthesis and Properties of PGS-Li Scaffold
Synthesis and Properties of PGS-Li Scaffold作者机构：Stomatology Hospital of Jilin University Changehun 130012 P. R. China The Seeond Hospital of Jilin University Changehun 130022 P R. China China-Japan Union Hospital of Jilin University Changehun 130033 P. R. China
出 版 物：《Chemical Research in Chinese Universities》 (高等学校化学研究（英文版）)
年 卷 期：2018年第34卷第4期
页 面：670-675页
核心收录：
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 09[农学] 070302[理学-分析化学] 0703[理学-化学] 0901[农学-作物学] 0836[工学-生物工程] 090102[农学-作物遗传育种]
基 金：Supported by the Development Project of the Pharmaceutical Industry of Jilin Province, China the "Double Ten Project" of Changchun City, China the Key Science and Technology Project of Jilin Province, China the Graduate Innovation Fund of Jilin University, China
主 题：Lithium Polyglycerol sebacate(PGS) Tissue engineering Dental cementum
摘 要：Lithium ion-doped polyglycerol sebacate scaftbld（PGS）-Li was synthesized by adding lithium ions to po- lyglycerol sebacate（PGS） during its crosslinking process due to the specific effects of lithium ions on periodontal li- gament cells, cementoblasts and the eminent performance of PGS. The molecular mass, composition, structure, porosity, thermal properties, and hydrophilicity of the composite were characterized by gel permeation chromatogra- phy（GPC）, Fourier transform infrared spectroscopy（FTIR）, inductively coupled plasma optical emission spectrome- ter（ICP-OES）, scanning electron microscopy（SEM）, X-ray photoelectron spectroscopy（XPS）, thermogravimetric analyzer（TGA） and contact angle measurments, and the degradation of the material was evaluated by in vitro degra- dation experiments. The biological activity of PGS-Li scaffold was detected by calcein-AM staining and cytotoxicity test. The results indicate that PGS-Li scaffold has been successfully synthesized, which has similar composition and structure to PGS, but slightly larger molecular weight. In addition, the porosity and pore size of PGS-Li scaffold ba- sically meet the requirements of engineering scaffold materials and the seaffold shows better performance in terms of hydrophilicity and thermal stability than PGS. In vitro degradation experimental results show that the degradation rate of PGS-Li scaffold is higher than that of PGS. What＇s more, the results of cytotoxicity test and cell staining show that there is no significant difference in the proliferation and cell morphology of cementoblasts.
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