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Delta Global奢侈品可持续调查报告:迈进绿色未来

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包装与设计 2024年第1期 52-61页

作者： Robert Lockyer Delta Global

随着全球对可持续发展议题的关注日益提升,消费者的环保意识正不断增强,这也深刻地影响着奢侈品购买行为。在香港设计营商周(BODW)2023峰会上,Delta Global创始人及首席客户总监Robert Lockyer带来了一份名为《迈进绿色未来》的调研报... 详细信息

随着全球对可持续发展议题的关注日益提升,消费者的环保意识正不断增强,这也深刻地影响着奢侈品购买行为。在香港设计营商周(BODW)2023峰会上,Delta Global创始人及首席客户总监Robert Lockyer带来了一份名为《迈进绿色未来》的调研报告。报告称,在接受调研的亚太区世代奢侈品消费者中,76%的人表示,他们愿意为重视可持续发展的奢侈品牌支付28%的产品溢价,并购买更多相关产品。

关键词：奢侈品牌可持续发展绿色未来 Delta 环保意识调研报告产品溢价

功能强、声音更强,了不起的“架势”Classé Audio Delta Pre MK Ⅱ前级放大器

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家庭影院技术 2024年第3期331卷 30-33页

作者： Frankie 不详

在正式开始评论文章之前,我先说一下关于我和一位发烧友之间故事。我的一个朋友有一天打电话给我。在电话里,他说到自己最近买了一套前后级功放,声音太让人惊喜了,要我有空去他家里感受感受。后来我到他家后才知道是Classeé Audio Delt... 详细信息

在正式开始评论文章之前,我先说一下关于我和一位发烧友之间故事。我的一个朋友有一天打电话给我。在电话里,他说到自己最近买了一套前后级功放,声音太让人惊喜了,要我有空去他家里感受感受。后来我到他家后才知道是Classeé Audio Delta Pre/Delta Stereo前后级功放。在听的过程当中,他不厌其烦的拿自己原来的功放做反复对比,也听了不少的唱片,Classé Audio Delta Pre/Delta Stereo给我们的最大感受就是具备非常出色的解析度、透明感和控制力,不同唱片公司之间的音色取向,不同价位之间唱片的音质差距更明显。

关键词：前级放大器解析度 Audio 透明感 Delta 功放音质控制力

A Limited Spreading Event of COVID-19 Caused by Delta Variant in a Cosmetic Hospital—Yantai City,Shandong Province,China,2021

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China CDC weekly 2022年第10期4卷 207-210页

作者： Yang Han Wenkui Sun Shengyang Zhang Bin Lin Jingyu Liu Runze Lu Xiaolin Jiang Jie Lei Shandong Provincial Center for Disease Control and Prevention JinanShandongChina Yantai Center for Disease Control and Prevention YantaiShandongChina Qingdao Center for Disease Control and Prevention QingdaoShandongChina

Summary What is already known about this topic?Coronavirus disease 2019(COVID-19)outbreaks in the past were mostly caused by overseas transmission,but if control measures are not appropriately applied,domestic transmission could also cause large-scale local epidemics.What is added by this report?This report covers all information of epidemic investigation processes,epidemiological characteristics and exposure history,transmission chains,sequencing results as well as public health measures taken for the COVID-19 cluster epidemic caused by the Delta variant in a cosmetic hospital in Yantai City in August 2021.What are the implications for public health practice?The information provided in this report,including active case finding,community management,and mass testing,may assist public health professionals in dealing with local COVID-19 epidemics caused by domestic transmission.

关键词： measures dealing Delta

Comparison of Omicron and Delta Variant Infection COVID-19 Cases—Guangdong Province,China,2022

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China CDC weekly 2022年第18期4卷 385-388页

作者： Ting Hu Meng Zhang Aiping Deng Yingtao Zhang Bosheng Li Yan Li Min Kang Guangdong Provincial Center for Disease Control and Prevention Guangzhou CityGuangdong ProvinceChina School of Public Health Southern Medical UniversityGuangzhou CityGuangdong ProvinceChina

What is already known about this topic?The Omicron variant has been listed as a variant of concern,but the characteristics still remain unclear.What is added by this report?The vaccinated proportion of 65 imported coronavirus disease 2019 cases that were infected with Omicron variant in this study was 89.23%,which was higher than Delta cases.Most imported cases infected with Omicron were tested positive using polymerase chain reaction after entering Guangdong within 3 days,a shorter period than Delta.

关键词： listed Guangdong Delta

Peptidic defective interfering gene nanoparticles against Omicron,Delta SARS-CoV-2 variants and influenza A virus in vivo

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Signal Transduction and Targeted Therapy 2022年第9期7卷 3484-3493页

作者： Hanjun Zhao Chuyuan Zhang Hoiyan Lam Xinjie Meng Zheng Peng Man Lung Yeung Jasper Fuk-Woo Chan Kelvin Kai-Wang To Kwok-Yung Yuen State Key Laboratory of Emerging Infectious Diseases Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Department of Microbiology School of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Centre for Virology Vaccinology and TherapeuticsHong Kong Science and Technology ParkHong Kong Special Administrative RegionChina Department of Infectious Disease and Microbiology The University of Hong Kong-Shenzhen HospitalShenzhenGuangdong ProvinceChina Carol Yu Centre for Infection The University of Hong KongPokfulamHong Kong Special Administrative RegionChina Guangzhou Laboratory GuangzhouGuangdong ProvinceChina

Defective interfering genes(DIGs)are short viral genomes and interfere with wild-type viral replication.Here,we demonstrate that the new designed SARS-CoV-2 DIG(CD3600)can significantly inhibit the replication of SARS-CoV-2 including Alpha,Delta,Kappa and Omicron variants in human HK-2 cells and influenza DIG(PAD4)can significantly inhibit influenza virus replication in human A549 cells.One dose of influenza DIGs prophylactically protects 90%mice from lethal challenge of A(H1N1)pdm09 virus and CD3600 inhibits SARS-CoV-2 replication in hamster lungs when DIGs are administrated to lungs one day before viral challenge.To further investigate the gene delivery vector in the respiratory tract,a peptidic TAT2-P1&LAH4,which can package genes to form small spherical nanoparticles with high endosomal escape ability,is demonstrated to dramatically increase gene expression in the lung airway.TAT2-P1&LAH4,with the dual-functional TAT2-P1(gene-delivery and antiviral),can deliver CD3600 to significantly inhibit the replication of Delta and Omicron SARS-CoV-2 in hamster lungs.This peptide-based nanoparticle system can effectively transfect genes in lungs and deliver DIGs to inhibit SARS-CoV-2 variants and influenza virus in vivo,which provides the new insight into the drug delivery system for gene therapy against respiratory viruses.

关键词： influenza vivo Delta

Characteristics of replication and pathogenicity of SARS-CoV-2 Alpha and Delta isolates

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Virologica Sinica 2022年第6期37卷 804-812页

作者： Xiao-Li Feng Dandan Yu Mi Zhang Xiaohong Li Qing-Cui Zou Wentai Ma Jian-Bao Han Ling Xu Cuixian Yang Wang Qu Zhong-Hua Deng Junyi Long Yanghaopeng Long Mingkun Li Yong-Gang Yao Xing-Qi Dong Jianxiong Zeng Ming-Hua Li Kunming National High-level Biosafety Research Center for Non-Human Primates Center for Biosafety Mega-ScienceKunming Institute of ZoologyChinese Academy of SciencesKunming650107China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesKunming Institute of ZoologyChinese Academy of SciencesKunming650201China National Resource Center for Non-Human Primates National Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility)Kunming Institute of ZoologyChinese Academy of SciencesKunming650107China Department of Infectious Diseases Yunnan Provincial Infectious Diseases HospitalKunming650301China Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciencesand China National Center for BioinformationBeijing100101China University of Chinese Academy of Sciences Beijing100049China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunming650201China Kunming College of Life Science University of Chinese Academy of SciencesKunming650204China Yunnan Key Laboratory of Biodiversity Information Kunming Institute of ZoologyChinese Academy of SciencesKunming650201China

The continuously arising of SARS-CoV-2 variants has been posting a great threat to public health safety globally,from B.1.17(Alpha), B.1.351(Beta), P.1(Gamma), B.1.617.2(Delta) to B.1.1.529(Omicron). The emerging or reemerging of the SARS-CoV-2 variants of concern is calling for the constant monitoring of their epidemics,pathogenicity and immune escape. In this study, we aimed to characterize replication and pathogenicity of the Alpha and Delta variant strains isolated from patients infected in Laos. The amino acid mutations within the spike fragment of the isolates were determined via sequencing. The more efficient replication of the Alpha and Delta isolates was documented than the prototyped SARS-CoV-2 in Calu-3 and Caco-2 cells, while such features were not observed in Huh-7, Vero E6 and HPA-3 cells. We utilized both animal models of human ACE2(hACE2)transgenic mice and hamsters to evaluate the pathogenesis of the isolates. The Alpha and Delta can replicate well in multiple organs and cause moderate to severe lung pathology in these animals. In conclusion, the spike protein of the isolated Alpha and Delta variant strains was characterized, and the replication and pathogenicity of the strains in the cells and animal models were also evaluated.

关键词： SARS-CoV-2 Variants of concern(VOC) Alpha Delta hACE2 transgenic mice Hamster

Infection and pathogenesis of the Delta variant of SARS-CoV-2 in Rhesus macaque

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Virologica Sinica 2022年第2期37卷 299-302页

作者： Ge Gao Xue Hu Yiwu Zhou Juhong Rao Xiaoyu Zhang Yun Peng Jiaxuan Zhao Yanfeng Yao Kunpeng Liu Mengying Liang Hang Liu Fei Deng Han Xia Chao Shan Zhiming Yuan Center for Biosafety Mega-Science Wuhan Institute of VirologyChinese Academy of SciencesWuhan430071China State Key Laboratory of Virology Wuhan Institute of VirologyChinese Academy of SciencesWuhan430071China Department of Forensic Medicine Tongji Medical College of Huazhong University of Science and TechnologyWuhan430030China University of Chinese Academy of Sciences Beijing100049China Key Laboratory of Special Pathogens and Biosafety Wuhan Institute of VirologyChinese Academy of SciencesWuhan430071China

Dear Editor,COVID-19 caused by SARS-Co V-2,is still a big threat to human populations around the world.As of Jan 2022,over 292 million cases were reported worldwide with more than 5.4 million deaths.After it was first reported in China in December 2019,the virus kept circulating and evolving and several variants with different transmissibility emerged in different countries and regions(WHO,2021a).

关键词： Delta milli emerged

ACE2-Targeting antibody suppresses SARS-CoY-2 Omicron and Delta variants

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Signal Transduction and Targeted Therapy 2022年第3期7卷 613-615页

作者： Jianxia Ou Yanan Zhang Yongmei Wang Zherui Zhang Hongping Wei Junping Yu Qi Wang Guifeng Wang Bo Zhang Chunhe Wang Biotheropeutics Discovery Research Center Shanghai Institute of Materia MedicoShanghaiChina School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjingChina Key Laboratory of Special Pathogens and Biosafety Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhanChina University of Chinese Academy of Sciences BeijingChina

Dear Editor,The pandemic of COVID-19 continues worldwide with many variants arising,especially SARS-CoV-2 Delta(B.1.617.2)and Omicron(B.1.1.529)variants of concern(VOCs).According to WHO,Omicron has spread in almost a... 详细信息

关键词： Delta doubling variants

SARS-CoV-2 Omicron RBD shows weaker binding affinity than the currently dominant Delta variant to human ACE2

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Signal Transduction and Targeted Therapy 2022年第2期7卷 359-361页

作者： Leyun Wu Liping Zhou Mengxia Mo Tingting Liu Chengkun Wu Chunye Gong Kai Lu Likun Gong Weiliang Zhu Zhijian Xu CAS Key Laboratory of Receptor Research Drug Discovery and Design CenterShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China College of Computer Science and Technology National University of Defense TechnologyChangsha 410073China Center for Drug Safety Evaluation and Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China

Dear Editor,SARS-coronavirus-2(SARS-CoV-2)Omicron variant(B.1.1.529)is of great concern to the world due to its multiple mutations that may have an impact on transmissibility and immune evasion.1 Compared to the wild type(WT),Omicron carries as many as 30 single point mutations,3 deletion mutation and one insertion mutation on its spike protein.Strikingly,there are 15 mutations observed in the Omicron receptor-binding domain(RBD),10 of which are in the receptor-binding motif(RBM)that human angiotensin-converting enzyme 2(ACE2)and most monoclonal antibodies(mAbs)interact directly with.As a comparison,the currently dominant variant Delta(B.1.617.2)has only 2 mutations(L452R and T478K)in its RBM and additional K417N and E484K mutations sometimes.Therefore,Omicron variant may significantly impact the binding affinity to ACE2 and effectiveness of currently available mAbs.Consequently,Omicron mutant has aroused wide concern,many countries have taken measures on entry restrictions to prevent its rapid spread.However,the transmissibility and immune evasion risk of Omicron have not been properly evaluated.

关键词： ACE2 Delta properly