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Effect of EGFR-TKI retreatment following chemotherapy for advanced non-small cell lung cancer patients who underwent EGFR-TKI

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Cancer Biology & Medicine 2014年第4期11卷 270-276页

作者： Guo-Hao Xia Yun Zeng Ying Fang Shao-Rong Yu Li Wang Mei-Qi Shi Wei-Li Sun Xin-En Huang Jia Chen Ji- Feng Feng Department of Medical Oncology Jiangsu Cancer Hospital

Objective:Non-small cell lung cancer(NSCLC)patients with epidermal growth factor receptor(EGFR)-activating mutations have higher response rate and more prolonged survival following treatment with single-agent EGFR tyrosine kinase inhibitor(EGFR-TKI)compared with patients with wild-type EGFR.However,all patients treated with reversible inhibitors develop acquired resistance over time.The mechanisms of resistance are complicated.The lack of established therapeutic options for patients after a failed EGFR-TKI treatment poses a great challenge to physicians in managing this group of lung cancer patients.This study evaluates the influence of EGFR-TKI retreatment following chemotherapy after failure of initial EGFR-TKI within at least 6 months on NSCLC patients.Methods:The data of 27 patients who experienced treatment failure from their initial use of EGFR-TKI within at least6 months were analyzed.After chemotherapy,the patients were retreated with EGFR-TKI(gefitinib 250 mg qd or erlotinib150 mg qd),and the tumor progression was observed.The patients were assessed for adverse events and response to therapy.Targeted tumor lesions were assessed with CT scan.Results:Of the 27 patients who received EGFR-TKI retreatment,1(3.7%)patient was observed in complete response(CR),8(29.6%)patients in partial response(PR),14(51.9%)patients in stable disease(SD),and 4(14.8%)patients in progressive disease(PD).The disease control rate(dcr)was 85.2%(95%CI:62%-94%).The median progression-free survival(m PFS)was 6 months(95%CI:1-29).Of the 13 patients who received the same EGFR-TKI,1 patient in CR,3 patients in PR,8 patients in SD,and 2 patients in PD were observed.The dcr was 84.6%,and the m PFS was 5 months.Of the 14 patients who received another EGFR-TKI,no patient in CR,6 patients in PR,6 patients in SD,and 2 patients in PD were observed.The dcr was 85.7%,and the m PFS was 9.5 months.Significant difference was found between the two groups in PFS but not in response rate or dcr.Conclusion:Retreatment of EGFR-TKIs can be considered an o

关键词：酪氨酸激酶抑制剂表皮生长因子受体非小细胞肺癌患者化疗晚期 EGFR dcr

Pemetrexed Monotherapy and Pemetrexed Plus Platinum Combination Therapy as Non-First-Line Treatments for Advanced Non-Small Cell Lung Cancer

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Clinical oncology and cancer resexreh 2011年第4期8卷 235-241页

作者： Fang WANG Gui-fang GUO Hui-juan QIU Xu-xian CHEN Pi-fi HU Fei-fei ZHOU Wen-zhuo HE Bei ZHANG Liang-ping XIA State Key Laboratory of Oncology in SouthChina Guangzhou 510060 GuangdongProvince China VIP Region Sun Yat-sen University CancerCenter Guangzhou 510060 GuangdongProvince China Tumor Center The Foshan First People'sHospital Foshan 510060 GuangdongProvince China

Data on the efficacy profiles of pemetrexed monotherapy and pemetrexed plus platinum combination therapy in the non-first-line setting for patients with advanced non-small cell lung cancer (NSCLC) are limited, and previous studies have reported contradictory results. This study investigated and compared the efficacy and toxicity profiles of these two regimens to provide a broader understanding of their dynamics. Previously treated patients with advanced and/or recurrent NSCLC who received pemetrexed monotherapy or pemetrexed plus platinum combination therapy between January 1, 2006, and December 31, 2009, at Sun Yat-sen University Cancer Center were evaluated. The primary endpoint of this study was progression-free survival (PFS), whereas the secondary endpoints were overall response rate (ORR), disease control rate (dcr), overall survival (OS), and toxicity. Survival was analyzed using the Kaplan-Meier method. Univariate analysis was performed to identify the factors potentially influencing OS, and chi-square analysis was carried out to compare ORR and dcr. Forty-six patients with advanced and/or recurrent NSCLC were analyzed; of these patients, 25 were given pemetrexed monotherapy and 21 received pemetrexed plus platinum combination therapy. The following correspond to the rates recorded for the pemetrexed monotherapy group and the pemetrexed plus platinum group: median PFS, 1.97 and 2.3 months (P=0.565); median OS, 30. 93 and 30.33 months (P=0.877); ORR, 8% (2/25) and 9.5% (2/21) (P=0.857); and dcr, 32% (8/25) and 57.1% (12/21) (P=0.09). Univariate analysis revealed that no factor was correlated with OS from NSCLC (P>0.05 for all). Gastrointestinal toxicity in the pemetrexed plus platinum group was modestly higher than that in the pemetrexed monotherapy group (P=0.034), but other adverse events were similar between the groups. Compared with pemetrexed monotherapy, pemetrexed plus platinum combination therapy causes more gastrointestinal toxicities and does not exhibit improved efficacy, in terms of ORR, dcr, P

关键词：非小细胞肺癌联合治疗单药晚期铂单因素分析 dcr PFS

MODELS OF ASYNCHRONOUS MRALLEL NONLINEAR MULTISPLITTING RELAXED ITERATIONS

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Journal of Computational Mathematics 1995年第4期13卷 369-386页

作者： Z.Z. Bai(Institute of Computational Mathematics and Scientific/Engineering Computing,Chinese Academy of Sciences, Beijing, China)D.R. Wang(Depariment of Mathematics, Shanghai University of Science and Technology,Shanghai, China)D.J. Evans(Parallel Algorit

In the sense of the nonlinear multisplitting and based on the principle of suffi-ciently using the delayed information, we propose models of asynchronous parallelaccelerated overrelaxation iteration methods for solving large scale system of non-linear equations. Under proper conditions, we set up the local convergence theoriesof these new method models.

关键词： NoC Wang MODELS OF ASYNCHRONOUS MRALLEL NONLINEAR MULTISPLITTING RELAXED ITERATIONS EN dcr

What are the ten new commandments in severe polytrauma management？

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World Journal of Emergency Medicine 2010年第2期1卷 85-92页

作者： CW Kam CH Lai SK Lam FL So CL Lau KH Cheung Accident & Emergency Department Tuen Mun Hospital Hong Kong China

This review aims to provide a concise overview of the trauma management evolution in the past decade. 1) Trauma care priorities have incorporated staff protection against infection and early decision making in addition to the conventional ABCDE. 2) Five stratified levels for DAM have replaced the non-specific conventional Plans A & B. 3) CT scanning can be the tunnel to death for the hemodynamically unstable patient. 4) DPL has virtually been replaced by the FAST USG. 5) Direct whole-body MDCT provides rapid imaging diagnosis & expedites the definitive treatment but carries high radiation hazards. 6) The dynamic shock assessment by fluid resuscitation response provides more outcome-specific evaluation than the static blood volume loss model. 7) dcr comprising of permissive hypotension, hemostatic resuscitation & DCS aims to overcome the lethal triad of trauma. Early transfusion of blood components of FFP & platelet concentrates improves the outcome in massive blood transfusion. 8) DCS aims to rectify the deranged physiology and not to fully restore the damaged anatomy. 9) A pre-defined protocol for major pelvic fracture can be life-saving and the novel Pre-PPP (pre-peritoneal pelvic packing) may further reduce mortality coupled with the necessary TCAE. 10) Injury prevention is equally important if not more than the trauma resuscitation & operation.

关键词： CT DAM dcr DCS DPL FAST Fluid resuscitation responder Injury prevention MDCT Polytrauma Pre-PPP Priorities

EGFR-TKIs联合中药与单纯EGFR-TKIs治疗晚期非小细胞肺癌的队列研究

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四川大学学报（医学版） 2018年第4期49卷 566-569,586页

作者：熊绍权李亚玲王淑美晋帅罗秋月丁倩宋婷婷王莉娟蔡蕊吕盼盼何成诗向洁成都中医药大学附属医院肿瘤科成都610075 重庆医科大学中医药学院中医科重庆400016 出生缺陷与相关妇儿疾病教育部重点实验室(四川大学) 成都610041

目的分析表皮生长因子受体酪氨酸激酶抑制剂(epidermal growth factor receptor-tyrosine kinase inhibitors,EGFR-TKIs)联合中药与单纯EGFR-TKIs一线治疗晚期非小细胞肺癌的疗效。方法采用队列研究,59例EGFR基因突变的晚期非小细胞肺... 详细信息

目的分析表皮生长因子受体酪氨酸激酶抑制剂(epidermal growth factor receptor-tyrosine kinase inhibitors,EGFR-TKIs)联合中药与单纯EGFR-TKIs一线治疗晚期非小细胞肺癌的疗效。方法采用队列研究,59例EGFR基因突变的晚期非小细胞肺癌患者,按2∶1比例分配至试验组(39例)和对照组(20例)。试验组采用EGFR-TKIs联合中药口服,对照组单用EGFR-TKIs。分析两组无进展生存期(progression-free-survival,PFS)、疾病控制率(disease control rate,dcr)和治疗相关不良反应发生率。结果试验组和对照组dcr分别是94.1%和84.2%(P=0.24)。试验组和对照组中位PFS(mPFS)分别为12.1月和9.1月(P<0.05);亚组分析显示,对于19号外显子缺失的患者,试验组和对照组mPFS分别为10.5月和9.5月(P=0.17);但对于21号外显子点突变(L858R)的患者,两组mPFS分别为13.2月和7.8月(P<0.05)。试验组3~4级治疗相关不良反应发生率低于对照组,分别为8.33%和15.00%(P=0.65)。结论 EGFR-TKIs联合中药可延长晚期非小细胞肺癌患者的PFS,对L858R患者的效果更好,值得进一步研究。

关键词：中药肺癌 EGFR-TKI PFS dcr

Research on Channel Codec of dcr System Based on CMX7141

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Communications and Network 2013年第3期5卷 286-291页

作者： Yufeng Li Jun Yang Qingyang Guan College of Electronic and Information Engineering Shenyang aerospace university Shenyang China College of Electronic and Information Engineering Shenyang aerospace university Shenyang China National Mobile Communications Research Laboratory Southeast University Nanjing China

This article introduces a digital private network of mobile communication dedicated chipset CMX7141 that used for the 4FSK modulation and demodulation in dcr system, and introduces the application of CMX7141 inthe dcr system. Focus research on the channel codec techniques of the chip and have a simulation on the channel coding and decoding. The simulation results indicate that, through channel error correction technique in CMX7141, the BER of dcr system reduces greatly and the transmission quality of dcr system is improved.

关键词： dcr CMX7141 Cyclic Redundancy Check Punctured Convolutional Coding

dcr视野下问题解决类协作学习设计的一项个案研究

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电化教育研究 2018年第11期39卷 5-12,68页

作者：杨开城刘晗北京师范大学教育学部北京100875

协作学习的设计一直是个理论难题,我们不清楚协作学习的具体方案何以具有目标—手段一致性以及那些设计要素何以会转化为令人满意的协作活动。与DBR(Design Based Research)不同,dcr(Design Centered Research)关注的是知识收获。文章在... 详细信息

协作学习的设计一直是个理论难题,我们不清楚协作学习的具体方案何以具有目标—手段一致性以及那些设计要素何以会转化为令人满意的协作活动。与DBR(Design Based Research)不同,dcr(Design Centered Research)关注的是知识收获。文章在dcr视野下,通过一项个案研究,初步确证了这样一组问题解决类协作学习的设计知识:(1)协作学习的设计方案由任务呈现、协作过程、成果呈现以及过程支架组成;(2)扩展的FC知识图不但可以用来设计问题,还可以用来设计协作过程的支架,是检查目标—手段一致性的重要工具。为了确证上述知识,本个案研究初次采用学习过程机制图来表征真实发生的协作过程。学习过程机制图主要用来判断协作学习方案中的那些设计要素是否转化为令人满意的协作活动。

关键词：协作学习问题解决扩展的FC知识图 dcr

dcr范式下教学系统质量的评测指标体系构建

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电化教育研究 2020年第3期41卷 48-55页

作者：何文涛周跃良李鸣华朱玲林李菲茗浙江师范大学教师教育学院教育技术学系浙江金华321004

基于DBR创生的情境性知识进行教学评测,多依赖从教者或专家的个人经验与个人智慧,主观性较强。为克服这一不足,研究基于dcr下的教学系统概念模型及IIS图分析法,以教学系统为研究对象,提出教学系统的质量评测应从教学系统的一致性、适应... 详细信息

基于DBR创生的情境性知识进行教学评测,多依赖从教者或专家的个人经验与个人智慧,主观性较强。为克服这一不足,研究基于dcr下的教学系统概念模型及IIS图分析法,以教学系统为研究对象,提出教学系统的质量评测应从教学系统的一致性、适应性和学生参与度三维度考虑,并以此为思考框架,构建出评测教学系统质量的指标体系,包括目标知识点的学习水平与任务类型的一致性、被激活的IIS子图与任务的知识组块的一致性、学习目标的层级多元性、媒体多元性、目标知识点的活动多元性、学生言语参与度、学生知识参与度、知识点总激活量、目标知识点总激活量等九大指标。这些指标值多通过教学系统中信息处理主体输出的信息流推算得来,难以干预,客观性较强。通过这些指标数据能客观、清楚地说明课堂教学的整体交互水平如何、教学手段与学习目标是否一致、学习目标的达成程度如何、教学系统能否应对突发教学问题及学生的课堂参与情况如何等反映教学系统质量的基本问题。

关键词： dcr IIS图教学系统一致性适应性参与度

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尼泊尔上博迪克西水电站重力坝修复

西北水电 2022年第4期 58-62页

作者：王伟范建朋中国电建集团西北勘测设计研究院有限公司西安710065

运用材料力学法和反应谱法分析验证了原地震动设计标准下大坝的安全性,通过动力时程法进行了地震加速度参数的敏感性分析,摸清了运行基准地震(OBE,Operational basis earthquake)和最大设计地震(MDE,Maximum design earthquake)工况下1... 详细信息

运用材料力学法和反应谱法分析验证了原地震动设计标准下大坝的安全性,通过动力时程法进行了地震加速度参数的敏感性分析,摸清了运行基准地震(OBE,Operational basis earthquake)和最大设计地震(MDE,Maximum design earthquake)工况下1号坝段的工作性态。新的1号坝段修复方案顺利完成并付诸实施,工程投资节省较多,保障了电站按时发电,经济效益显著。

关键词：重力坝修复材料力学法反应谱动力时程 dcr