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Characteristics of recipients with complete immunosuppressant withdrawal after adult liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2017年第4期16卷 437-439页

作者： Lei Geng Jun-Jie Huang Bing-Yi Lin Tian-Chi Chen Tian Shen Shu-Sen Zheng Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Key Lab of Combined Multi-Organ Transplantation Ministry of Public Health and Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesHangzhou 310003China

To the Editor:Liver transplantation(LT)is an effective therapeutic method for end-stage liver diseases.Although rejection is commonly mild or moderate in LT compared with other solid organs transplantation,it is still requiring a life-long immunosuppressive therapy.Meanwhile,LT is less sensitive to rejection than other organs transplantation due to liver immune privilege which even allows

关键词： of is in HCC DCD with

基于填充函数与DCD的全局优化算法及其反演

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应用力学学报 2021年第1期38卷 361-366页

作者：吕颖慧高峰秦磊济南大学土木建筑学院济南250022

岩土工程中以监测位移为已知信息的反演问题可通过带未知变量约束空间的优化模型去求解。该模型中的优化函数常具有非线性、非凸性等特点,使得反演结果容易陷入局部最优的困境。为了应对在运用优化算法反演此类问题时存在的困境,并提高... 详细信息

岩土工程中以监测位移为已知信息的反演问题可通过带未知变量约束空间的优化模型去求解。该模型中的优化函数常具有非线性、非凸性等特点,使得反演结果容易陷入局部最优的困境。为了应对在运用优化算法反演此类问题时存在的困境,并提高其算法效率,依据填充函数优化思想与DCD(Dynamic Canonical Descent)思想在反演时的优良全局搜索能力及其算法优化特点,提出了基于填充函数和DCD思想的联合反演全局优化算法,并给出了其反演迭代形式。数值计算和工程应用结果均表明:对于随机给定的任何一组初始反演值,本算法都能稳定且快速地收敛到反演真值。该联合算法具有数值计算稳定性好、全局优化能力强、收敛速度快等优点,将其应用于岩土工程中的非线性反演求解中具有较好的前景。

关键词：填充函数 DCD 联合迭代全局优化非线性反演

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DCD肝移植术后胆道并发症的危险因素分析

DCD肝移植术后胆道并发症的危险因素分析

作者：曹助新疆医科大学

学位级别：硕士

目的:公民逝世后器官捐献(Donation after citizens death,DCD)肝移植术后胆道并发症(Biliary Complications,BC)发生可导致受体生存质量下降,故并对新疆医科大学第一附属医院器官中心肝移植相关临床资料进行分析、总结,从而对我院肝移... 详细信息

目的:公民逝世后器官捐献(Donation after citizens death,DCD)肝移植术后胆道并发症(Biliary Complications,BC)发生可导致受体生存质量下降,故并对新疆医科大学第一附属医院器官中心肝移植相关临床资料进行分析、总结,从而对我院肝移植术后BC危险因素评估,减少肝移植术后BC发生,进而有效提高DCD肝移植患者术后长期生存质量。方法:作者收集我院器官中心自2013年9月至2021年1月施行37例次DCD肝脏移植手术受体临床资料含括受体年龄、性别、BMI、冷缺血时间、乙肝病毒(+、-)、血型是否匹配、热缺血时间、Child-Pugh评级、Meld评分、手术时间、术中出血量、无肝期、ICU收住天数、有无移植物排斥反应。并对以上指标进行两组对比分析。结果:在37例受体中,3例受体因移植术后3天内死亡给予去除。其中34例患有胆道并发症9例,非胆道并发症25例,胆道并发症占总数的百分比为26.5%,男性受体23例,在男性受体中7例BC,占男性受体30.4%,女性受体11例,在女性受体中2例BC,占女性受体22.2%。其中纳入本组研究有9例胆道并发症,非胆道并发症25例,其中非吻合口狭窄(NABS)2例、吻合口狭窄(ABS)2例、非吻合口狭窄(NABS)+胆管结石2例、吻合口狭窄(ABS)+胆管结石1例,非吻合口狭窄(NABS)+胆管结石+胆道感染1例,胆漏+吻合口狭窄(ABS)1例。胆道并发症早期(≦1月)2例,占胆道并发症22.2%。胆道并发症晚期(>1月)7例,占胆道并发症77.8%。经过单因素分析结果可以得出,两组间受体年龄、性别、乙肝病毒(+、-)、血型是否匹配、Child-Pugh评分、MELD评分、手术时间、术中出血量、无肝期、受体ICU收住天数、有无移植物排斥反应无统计学意义,热缺血时间(P=0.000)、冷缺血时间(P=0.048)、BMI(P=0.031)对胆道并发症的发生有统计学意义;行二元logistic分析显示发现热缺血时间为术后BC独立危险因素。结论:热缺血时间是肝移植术后BC独立危险因素,冷缺血时间、BMI不是独立危险因素,但与移植后胆道并发症密切相关。因样本量较少,结果可能会出现偏倚,故需多中心多样本进一步研究。

关键词： DCD 肝移植胆道并发症热缺血时间冷缺血时间

Implementing an innovated liver ex-situ machine perfusion technology:The 2018 Joint International Congress of ILTS,ELITA and LICAGE

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Hepatobiliary & Pancreatic Diseases International 2018年第4期17卷 283-285页

作者： Jun-Jun Jia Jian-Hui Li Hai-Yang Xie Lin Zhoua Shu-Sen Zheng Division of Hepatobiliary Pancreatic Surgery First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Key Laboratory of Combined Multi-Organ Transplantation Ministry of Public HealthFirst Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

The 2018 Joint International Congress of ILTS,ELITA and LICAGE were held in Lisbon,Portugal on May 23–26,2018.The exciting and innovative program brought together 1144 experts in liver transplantation(LT)such as surgeons,physicians or basic scientists from 61 countries.The presentations included 110 invited speakers,181 oral presentations,and 545 posters.This editorial highlights some of the most innovative and impactful presentations in

关键词： NMP WIT DCD Implementing an innovated liver ex-situ machine perfusion technology:The 2018 Joint International Congress of ILTS,ELITA and LICAGE

Machine perfusion versus cold storage of livers： a meta-analysis

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Frontiers of Medicine 2016年第4期10卷 451-464页

作者： Sushun Liu Qing Pang Jingyao Zhang Mimi Zhai Sinan Liu Chang Liu Department of Hepatobiliary Surgery The First Affiliated Hospital School of Medicine Xi 'an Jiaotong University Xi 'an 710061 China

Abstract Different organ preservation methods are key factors influencing the results of fiver transplantation. In this study, the outcomes of experimental models receiving donation after cardiac death （DCD） livers preserved through machine perfusion （MP） or static cold storage （CS） were compared by conducting a meta-analysis. Standardized mean difference （SMD） and 95% confidence interval （CI） were calculated to compare pooled data from two animal species. Twenty-four studies involving MP preservation were included in the meta-analysis. Compared with CS preservation, MP can reduce the levels of aspartate aminotransferase （AST）, alanine aminotransferase （ALT）, lactate dehydrogenase （LDH）, and hyaluronic acid （HA） and the changes in liver weight. By contrast, MP can enhance bile production and portal vein flow （PVF）. Alkaline phosphatase （ALP） levels and histological changes significantly differed between the two preservation methods. In conclusion, MP of DCD livers is superior to CS in experimental animals.

关键词： machine perfusion cold storage DCD meta-analysis

养殖肥液施用方式配合NBPT-DCD对土壤N_(2)O的减排效应

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节水灌溉 2021年第7期 26-30,35页

作者：颜青赖睿特张克强梁军锋杨涵博王风农业农村部环境保护科研监测所天津300191

为探究不同养殖肥液施用方式(漫灌和覆土)配合脲酶-硝化抑制剂组合(N-丁基硫代磷酰三胺NBPT+双氰胺DCD)对土壤N_(2)O排放的影响。通过室内培养试验,设置不施氮(CK)、漫灌施用(S)、覆土施用(D)、漫灌施用+NBPT-DCD组合(S+UI+NI)、覆土施... 详细信息

为探究不同养殖肥液施用方式(漫灌和覆土)配合脲酶-硝化抑制剂组合(N-丁基硫代磷酰三胺NBPT+双氰胺DCD)对土壤N_(2)O排放的影响。通过室内培养试验,设置不施氮(CK)、漫灌施用(S)、覆土施用(D)、漫灌施用+NBPT-DCD组合(S+UI+NI)、覆土施用+NBPT-DCD组合(D+UI+NI)共5个处理。结果表明:养殖肥液施用方式显著影响土壤N_(2)O排放。肥液漫灌明显促进了土壤N_(2)O排放,其累积排放量最高达2420.39μg/m^(2);肥液覆土施用显著降低土壤N_(2)O排放峰值,并延迟出峰时间,其N_(2)O累积排放量与漫灌施用相比减少21.94%~72.90%。添加NBPT-DCD有利于降低土壤N_(2)O排放,其中D+UI+NI处理的土壤N_(2)O累积排放量较D处理减少5.96%~33.80%,表观硝化率在各施肥处理中最低仅40.65%。因此,覆土施肥可以有效减少养殖肥液漫灌造成的土壤N_(2)O排放,配合NBPT-DCD施用后N_(2)O减排效果更佳。

关键词：养殖肥液覆土 NBPT DCD N2O

A Block Parallel l_0-Norm Penalized Shrinkage and Widely Linear Affine Projection Algorithm for Adaptive Filter

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China Communications 2017年第1期14卷 86-97页

作者： Youwen Zhang Shuang Xiao Lu Liu Dajun Sun Acoustic Science and Technology Laboratory Harbin Engineering University Harbin 150001 China College of Underwater Acoustic Engineering Harbin Engineering University Harbin 150001 China

To improve the identification capability of AP algorithm in time-varying sparse system, we propose a block parallel l_0-SWL-DCD-AP algorithm in this paper. In the proposed algorithm, we first introduce the l_0-norm constraint to promote its application for sparse system. Second, we use the shrinkage denoising method to improve its track ability. Third, we adopt the widely linear processing to take advantage of the non-circular properties of communication signals. Last, to reduce the high computational complexity and make it easy to implemented, we utilize the dichotomous coordinate descent(DCD) iterations and the parallel processing to deal with the tapweight update in the proposed algorithm. To verify the convergence condition of the proposed algorithm, we also analyze its steadystate behavior. Several simulation are done and results show that the proposed algorithm can achieve a faster convergence speed and a lower steady-state misalignment than similar APA-type algorithm. When apply the proposed algorithm in the decision feedback equalizer(DFE), the bite error rate(BER) decreases obviously.

关键词： signal processing adaptive algorithm LMS l0-norm shrinkage linear DCD

Severe and delayed immune-mediated hemolysis post-liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2017年第6期16卷 665-668页

作者： Quan Zhuang Hong Liu Ke Cheng Ying Niu Xing-Guo She Ying-Zi Ming Transplantation Center of the Third Xiangya Hospital Central South University Changsha 410013 China

To the Editor:Hemolysis,which is caused by a variety of immune and non-immune mechanisms,is a well-recognized complication of solid organ transplantation.;Hemolysis post-liver transplantation can be induced by drug,in... 详细信息

关键词： RBC Severe and delayed immune-mediated hemolysis post-liver transplantation PLS DCD EBV

Responses of Ammonia-Oxidizing Bacteria and Archaea in Two Agricultural Soils to Nitrification Inhibitors DCD and DMPP: A Pot Experiment

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Pedosphere 2013年第6期23卷 729-739页

作者： GONG Ping ZHANG Li-Li WU Zhi-Jie CHEN Zhen-Hua CHEN Li-Jun Institute of Applied Ecology Chinese Academy of Sciences University of Chinese Academy of Sciences State Key Laboratory of Forest and Soil Ecology Institute of Applied EcologyChinese Academy of Sciences

Taking two important agricultural soils with diferent pH,brown soil(Hap-Udic Luvisol)and cinnamon soil(Hap-Ustic Luvisol),from Northeast China,a pot culture experiment with spring maize(Zea mays L.)was conducted to study the dynamic changes in the abundance and diversity of soil ammonia-oxidizing bacteria(AOB)and ammonia-oxidizing archaea(AOA)populations during maize growth period in response to the additions of nitrification inhibitors dicyandiamide(DCD)and 3,4-dimethylpyrazole phosphate(DMPP)by the methods of real-time polymerase chain reaction(PCR)assay,PCR-denaturing gradient gel electrophoresis(DGGE),and construction of clone library targeting the amoA gene.Four treatments were established,i.e.,no urea(control),urea,urea plus DCD,and urea plus DMPP.Both DCD and DMPP inhibited growth of AOB significantly,compared to applying urea alone.Soil bacterial amoA gene copies had a significant positive linear correlation with soil nitrate content,but soil archaeal amoA gene copies did not.In both soils,all AOB sequences fell within Nitrosospira or Nitrosospira-like groups,and all AOA sequences belonged to group 1.1b crenarchaea.With the application of DCD or DMPP,community composition of AOB and AOA in the two soils had less change except that the AOB community composition in Hap-Udic Luvisol changed at the last two growth stages of maize under the application of DCD.AOB rather than AOA likely dominated soil ammonia oxidation in these two agricultural soils.

关键词：氨氧化细菌农业土壤 DMPP 硝化抑制剂盆栽试验 DCD 古细菌变性梯度凝胶电泳