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Protective Activity of <i>Markhamia tomentosa</i>(Benth.) K. Schum. (Bignoniaceae) Methanol Leaves Extract against d-galactosamine/lipopolysaccharide-Induced Acute Liver Injury in Mice

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Journal of Biosciences and Medicines 2020年第10期8卷 74-89页

作者： Roméo Joel Guemmogne Temdie Agathe Lambou Fotio Flaure donfack Metchi Edwige Chiogo Vouffo Ymele Gilbert Thierry Nkoulou Tabi Théophile dimo department of Biological Sciences Faculty of Science University of Ngaoundere Ngaoundere Cameroon department of Zoology and Animal Physiology Faculty of Science University of Buea Buea Cameroon department of Animal Biology and Physiology Faculty of Science University of Yaounde I Yaounde Cameroon

Markhamia tomentosa (Benth.) K. Schum. (Mt) is a Cameroonian medicinal plant, traditionally used to treat painful and inflammatory illness. This study aimed to examine the effects of methanol leaves extract (MLE) of Mt in D-galactosamine (D-GaIN)/lipopolysaccharide (LPS)-induced liver injury. The MLE (100 and 200 mg/kg), Ascorbic acid (10 mg/kg) and distilled water were administered 12 h and 1 h before intraperitoneal injection of D-GaIN (10 mg/mouse)/LPS (0.1 μg/g). Animals were sacrificed 6 h after D-GalN/LPS challenge. Liver injury was assessed biochemically by determination of aspartate aminotransferase (ASAT), alanine aminotransferase (ALAT), alkaline phosphatase (ALP), superoxide dismutase (SOd) and catalase activities. Malondialdehyde (MdA), reduced glutathione (GSH), nitrites, total protein and bilirubin levels were explored. Histopathological examination of liver tissue was also performed. Liver enzymes (ALAT, ASAT, ALP) activity, nitrites, MdA and bilirubin levels were increased, while protein level, SOd and catalase activities were significantly reduced by D-GalN/LPS administration. MLE (100 or 200 mg/kg) protected mice against D-GalN/LPS-induced death. In addition, the plant extract significantly reduced ALAT and ALP activity, exhibiting 23.00% and 62.20% protection, respectively. SOd activity and total protein were significantly (p d by the plant extract. Total bilirubin and MdA levels were reduced (p d 62.79%, respectively in animal treated with MLE. Histological analysis of liver sections showed that MLE (100 or 200 mg/kg) protected mice against D-GaIN/LPS-induced liver injury. The obtained results

关键词： Markhamia tomentosa d-galactosamine/lipopolysaccharide Oxidative Stress Liver Injury

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Sinapic acid ameliorates d-galactosamine/lipopolysaccharideinduced fulminant hepatitis in rats:Role of nuclear factor erythroidrelated factor 2/heme oxygenase-1 pathways

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World Journal of Gastroenterology 2021年第7期27卷 592-608页

作者： Mushtaq Ahmad Ansari Mohammad Raish Yousef A Bin Jardan Ajaz Ahmad Mudassar Shahid SheikhFayaz Ahmad Nazrul Haq Mohammad Rashid Khan Saleh A Bakheet department of Pharmacology and Toxicology College of PharmacyKing Saud UniversityRiyadh 11451Saudi Arabia department of Pharmaceutics College of PharmacyKing Saud UniversityRiyadh 11451Saudi Arabia department of Clinical Pharmacy College of PharmacyKing Saud UniversityRiyadh 11451Saudi Arabia

BACKGROUNd Sinapic acid(SA)has been shown to have various pharmacological properties such as antioxidant,antifibrotic,anti-inflammatory,and anticancer *** mechanism of action is dependent upon its ability to curb free radical production and protect against oxidative stress-induced tissue *** To study the hepatoprotective effects of SA against lipopolysaccharide(LPS)/dgalactosamine(d-GalN)-induced acute liver failure(ALF)in *** Experimental ALF was induced with an intraperitoneal(i.p.)administration of 8μg LPS and 800 mg/kg d-GalN in normal *** was administered orally once daily starting 7 d before LPS/d-GalN *** data showed that SA ameliorates acute liver dysfunction,decreases serum levels of alanine transaminase(ALT),and aspartate aminotransferase(AST),as well as malondialdehyde(MdA)and NO levels in ALF model ***,pretreatment with SA(20 mg/kg and 40 mg/kg)reduced nuclear factor kappalight-chain-enhancer of activated B cells(NF-κB)activation and levels of inflammatory cytokines(tumor necrosis factor-αand interleukin 6).Also,SA increased the activity of the nuclear factor erythroid-related factor 2/heme oxygenase-1(Nrf2/HO-1)signaling *** In conclusion,SA offers significant protection against LPS/d-GalN-induced ALF in rats by upregulating Nrf2/HO-1 and downregulating NF-κB.

关键词： Sinapic acid d-galactosamine/lipopolysaccharide Oxidative stress Fulminant hepatitis Antioxidant Nuclear factor erythroid-related factor 2/heme oxygenase-1 pathways

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