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Prognosis and immunological role of HLA-DMA in lung adenocarcinoma

BIOCELL 2023年第6期47卷 1279-1292页

作者： QIN YU CHEN CHEN HAIYAN ZHANG JIN CHEN JUNKANG SHEN JUN YAN Department of Imaging The Second Affiliated Hospital of Soochow UniversitySuzhou215000China Department of Imaging Dongtai People’s HospitalDongtai224000China Institute of Imaging Medicine Soochow UniversitySuzhou215000China Department of Orthopedics Dongtai People’s HospitalDongtai224000China Department of Orthopedics The Second Affiliated Hospital of Soochow UniversitySuzhou215000China Department of Pathology The Third People’s Hospital of NantongNantong226001China

Background:HLA-DMA presents pathogen-derived antigens to CD4+and CD8+T cells,respectively,and plays a significant part in initiating the immune *** far,the impact of HLA expression on the prognosis of BC cells is controversial,because few studies have shown that the expressions of some HLA genes are related to the improvement of the survival *** till now,however,the relationship between HLA-DMA and LUAD has not yet been ***:We analyzed the TCGA database and assessed the prognostic value of HLA-DMA in *** conducted the Kruskal–Wallis and Wilcoxon signed-rank test and utilized logistic regression to assess the role of clinical-pathologic characteristics and HLA-DMA ***–Meier method and the multivariate and univariate Cox regression were also used for evaluating the prognosis-related factors of *** was used to identify HLA-DMA-related key *** ssGSEA of the TCGA data was used to investigate the correlations between HLA-DMA and cancer immune cell ***:Low HLA-DMA expression was related to poorer disease-specific survival(DSS)and overall survival(OS)of LUAD *** revealed that HLA-DMA was tightly interrelated with an immune response by the reactome activation of anterior hox genes in hindbrain development during the early embryogenesis signaling *** expression of HLA-DMA was positively associated with cytotoxic cell infiltration and negatively related to the Th2 cell infiltration according to the *** blotting and the CCK-8 assay showed that KD-HLA-DMA could significantly increase the proliferation of A549 cells and significantly reduce cell ***:All the observations implied that HLA-DMA was associated with patient prognosis and immune infiltration in LUAD.

关键词： HLA-DMA Lung adenocarcinoma Tumor-infiltration Prognosis cytotoxic cells

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