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Coronavirus disease 2019 severity in obesity:Metabolic dysfunctionassociated fatty liver disease in the spotlight

World Journal of Gastroenterology 2021年第16期27卷 1738-1750页

作者： Isabela Macedo Lopes Vasques-Monteiro Vanessa Souza-Mello Anatomy Rio de Janeiro State UniversityRio de Janeiro 20551030Brazil Food Science and Technology Federal University of the State of Rio de JaneiroRio de Janeiro 22290250Brazil Laboratory of Morphometry Metabolismand Cardiovascular DiseasesBiomedical CenterInstitute of BiologyAnatomy DepartmentRio de Janeiro State UniversityRio de Janeiro 20551030Brazil

The coronavirus disease 2019(COVID-19)outbreak has drawn the scientific community's attention to pre-existing metabolic conditions that could aggravate the infection,causing extended viral shedding,prolonged hospitalization,and high death *** dysfunction-associated fatty liver disease(MAFLD)emerges as a surrogate for COVID-19 severity due to the constellation of metabolic alterations it *** review outlines the impact MAFLD exerts on COVID-19 severity in obese subjects,besides the possible mechanistic links to the poor *** data collected showed that MAFLD patients had poorer COVID-19 outcomes than non-MAFLD obese *** is generally accompanied by impaired glycemic control and systemic arterial hypertension,both of which can decompensate during the COVID-19 clinical ***,MAFLD subjects had higher plasma inflammatory marker concentrations than non-MAFLD subjects,which might be related to an intensified cytokine storm syndrome frequently associated with the need for mechanical ventilation and *** conclusion,MAFLD represents a higher risk than obesity for COVID-19 severity,resulting in poor outcomes and even progression to non-alcoholic *** should include MAFLD subjects in the high-risk group,intensify preventive measurements,and prioritize their vaccination.

关键词： Metabolic dysfunction-associated fatty liver disease Obesity COVID-19 Severity cytokine storm syndrome

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Severe progression of autoimmune hepatitis in a young COVID-19 adult patient: A case report

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Journal of Acute Disease 2022年第4期11卷 161-164页

作者： Neeraj Kumar Sushant Satyapriya Shaik Mohammad Tahaseen Kunal Singh Abhyuday Kumar Department of Trauma&Emergency AIIMS PatnaBiharIndia801505 Department of Anaesthesiology AIIMS PatnaBiharIndia801505 Department of Medicine AIIMS PatnaBiharIndia801505

Rationale:The impact of COVID-19 in patients with autoimmune liver disease treated with immunosuppressive therapy has not been described so *** case report describes the clinical course of a patient with autoimmune hepatitis(AIH)who developed COVID-19 and the features of cytokine syndrome leading to its deterioration in our intensive care ***’s Concern:A 28-year-old male presented with generalized anasarca for two weeks and chronic liver disease for 8 ***:AIH and Covid-19 with features of cytokine storm ***:Intravenous furosemide,mannitol,syrup lactulose,steroids(prednisolone 40 mg),azathioprine 1 mg/kg body weight,rifaximin,vitamin K,and blood ***:The patient had hepatic encephalopathy and AIH and died on the 10th day after admission despite ventilatory support,sustained low-efficiency hemodialysis,and ***:The dramatic release of cytokines and the inflammatory‐immune responses not only alter the pathophysiology but also affects the onset and severity of disease progression in patients with AIH.

关键词： COVID-19 Autoimmune hepatitis cytokine storm syndrome Immunosuppressant drugs Liver dysfunction

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