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cyanidin-3-o-glucoside alleviates trimethyltin chloride-induced neurodegeneration by maintaining glutamate homeostasis through modulation of the gut microbiota

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Food Science and Human Wellness 2024年第2期13卷 1093-1107页

作者： Yu Xi Wenhui Li Junru Wang Meihong Yu Xiangquan Zeng He Li Jian Li Key Laboratory of Green and Low-Carbon Processing Technology for Plant-Based Food of China National Light Industry Council Beijing Advanced Innovation Center for Food Nutrition and Human HealthBeijing Technology and Business UniversityBeijing 100048China

Trimethyltin chloride(TMT)is a potent neurotoxin to cause neurodegeneration,especially in *** study aimed to identify dietary components that can effectively attenuate TMT-induced neurodegeneration in *** predominant anthocyanin in human diets,cyanidin-3-o-glucoside(C3G,5 or 50 mg/kg),was given to mice for 16 days,and TMT(2.7 mg/kg)was injected intraperitoneally once on the eighth day.C3G(50 mg/kg)significantly alleviated TMT-induced seizures and subsequent cognitive impairment by ameliorating hippocampal neurodegeneration and synaptic ***,C3G treatment restored glutamate homeostasis in brain and reversed glutamine synthetase(GS)inhibition in reactive astrogliosis and neuroinflammation,which are critical for C3G's neuroprotective ***,C3G decreased the lipopolysaccharide,tumor necrosis factor-α,interleukin-6,and interleukin-1βlevels in the mice,which potentially by modulating the relative abundance of Atopobiaceae and Lachnospiraceae in the gut.C3G may be a promising and practical dietary component for reducing TMT-induced neurodegeneration.

关键词： cyanidin-3-o-glucoside Trimethyltin Neurodegeneration Glutamatergic pathway Gut microbiota

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Synergistic effects of alginate oligosaccharide and cyanidin-3-o-glucoside on the amelioration of intestinal barrier function in mice

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Food Science and Human Wellness 2023年第6期12卷 2276-2285页

作者： Jie Li Yuanjie Guo Liyuan Ma Yixiang Liu Chao Zou Huiying Kuang Bing Han Yingliang Xiao Yanbo Wang College of ocean Food and Biological Engineering Xiamen Key Laboratory of Marine Functional FoodFujian Provincial Engineering Technology Research Center of Marine Functional FoodJimei UniversityXiamen 361021China Collaborative Innovation Center of Provincial and Ministerial Co-construction for Marine Food Deep Processing Dalian Polytechnic UniversityDalian 116034China Gaoan Public Inspection and Testing Center Gaoan 330800China School of Food Science and Biotechnology Zhejiang Gongshang UniversityHangzhou 310018China

Emerging evidence shows that dietary oligosaccharides are important prebiotics that can improve intestinal flora,while dietary polyphenols can act directly on intestinal ***,information about their synergistic effects on gut health is still *** this study,alginate oligosaccharide(AoS)and cyanidin-3-o-glucoside(C3G)were selected as a common marine plant oligosaccharide and terrestrial plant polyphenol,respectively,to study their effects on intestinal *** results show that,in comparison to their individual applications,the combination of AoS and C3G(mass ratio,3:1)displayed a stronger ability to up-regulate the expression of tight junction proteins,while enhanced intestinal epithelial barrier was also observed and levels of mucin-2 andβ-defensins were simultaneously increased in the intestinal ***,the secretion of immunoglobulin A and immune-related cytokines were approximately doubled by the AoS+C3G *** addition,the AoS+C3G mixture was found to be more conducive to the positive transformation of intestinal flora,which stimulated the growth of beneficial bacteria Akkermansia,Lachnospiraceae and Feacalibaculum while inhibiting the growth of harmful bacteria Helicobacter and *** data generated herein thus suggests that dietary oligosaccharides and dietary polyphenols may be more beneficial to intestinal health when applied in combination than their individual effects alone.

关键词： Alginate oligosaccharide cyanidin-3-o-glucoside Prebiotics Intestinal barrier function Gut microbiota

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Freeze-dried jaboticaba (Myrciaria jaboticaba) peel powder, a rich source of anthocyanins and phenolic acids, mitigates inflammation-driven colorectal cancer in mice

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FooD BIoSCIENCE 2023年第3期53卷 1060-1071页

作者： do Nascimento, Roberto de Paula Rizzato, Julia Soto Polezi, Gabriele Moya, Amanda Maria Tomazini Munhoz Silva, Milena Ferreira Machado, Ana Paula da Fonseca Franchi Junior, Gilberto Carlos Borguini, Renata Galhardo Santiago, Manuela Cristina Pessanha de Araujo Paiotti, Ana Paula Ribeiro Pereira, Jose Aires Martinez, Carlos Augusto Real Marostica Junior, Mario Roberto Univ Campinas UNICAMP Sch Food Engn FEA Dept Food Sci & Nutr DECAN Lab Nutr & Metab LANUM Campinas SP Brazil Univ Campinas UNICAMP Sch Food Engn FEA Dept Food Sci & Nutr DECAN Lab Food Nutr & Hlth Campinas SP Brazil Fed Univ Sao Paulo UNIFESP Lab Cellular & Behav Pharmacol Diadema Campus Diadema SP Brazil Univ Campinas UNICAMP Integrated Res Ctr Onco Hematol Childhood Dis Sch Med Sci FCM Campinas SP Brazil Brazilian Agr Res Corp EMBRAPA Embrapa Food Technol Rio De Janeiro RJ Brazil Fed Univ Sao Paulo UNIFESP Lab Hepatol Mol Appl Discipline Gastroenterol Sao Paulo Campus Sao Paulo SP Brazil Sao Francisco Univ USF Postgrad Program Hlth Sci Braganca Paulista Campus Braganca Paulista SP Brazil

This study aimed to characterize the peel of jaboticaba (Myrciaria jaboticaba (Vell.) o. Berg) by spectrophotometry and chromatography, and investigate its effects on mice with inflammation-driven colorectal cancer (CRC). Freeze-dried jaboticaba peel (FDJP) showed a high antioxidant capacity in vitro, and to be mostly a source of cyanidin-3-o-glucoside, gallic acid, and ellagic acid. In the animal bioassay, FDJP added at 5% in the diet during 114 days completely abolished the formation of adenocarcinoma, which had an incidence of 75% in the non-treated group. Animals consuming FDJP showed low histology damage regarding inflammatory infiltrate, edema, and crypt distortion. FDJP significantly reduced the colonic levels of proinflammatory markers interleukin-1beta and cyclooxygenase-2, and demonstrated a probability to decrease the expressions of inducible nitric oxide synthase and nuclear factor kappa B. In summary, FDJP mitigated CRC, possibly by avoiding triggering inflammation. Such benefit may come from its rich content in anthocyanins and phenolic acids.

关键词： Brazil Carcinogenesis Colitis cyanidin-3-o-glucoside Flavonoid Fruit

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Health benefits of black rice——A review

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Grain & oil Science and Technology 2019年第4期2卷 109-113页

作者： Balasubramaniam Jaya Prasad Pazhaniyandi Subramania Sharavanan Rengaraj Sivaraj Department of Botany Annamalai UniversityAnnamalai Nagar 608002India Department of Botany Govt Arts CollegeMannargudi 614001India Department of Pharmacology Annamalai UniversityAnnamalai Nagar 608002India

Rice has been a staple food across the globe since time ***,different types of rice,such as white,purple,red,brown,and black rice,are named following the physical appearance of the rice *** color of the rice bran differs due to the presence of pigments in the rice *** from general uses like cooking and fodder for cattle,rice has also been extensively involved in the field of medicine,some of which have been scientifically *** pigmented rice varieties have a history of heritage and are admired all over the world,awareness concerning the benefits of consuming these types of rice is *** main theme of this research article is to define the scientifically proven medicinal properties of black *** health properties of black rice are experimentally renowned,and gathered empirical data regarding the physiological and pharmacological activity of black rice remarkably supports the use of black rice in nutritional therapy.

关键词： Black rice cyanidin-3-o-glucoside Diabetes Dragon eyeball 100 Insulin resistance oryza sativa

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Effect of Postharvest Methyl Jasmonate Treatment on Early-Matured “Hass” Avocado Fruit Exocarp Colour Development during Ripening

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Agricultural Sciences 2021年第8期12卷 875-887页

作者： Kingsly Shikwambana Tieho P. Mafeo Nhlanhla Mathaba School of Agriculture and Environmental Sciences Faculty of Science and Agriculture University of Limpopo Sovenga Polokwane South Africa Postharvest Management and Food Security School of Agricultural Science Faculty of Agriculture and Natural Sciences University of Mpumalanga Nelspruit South Africa

Poor exocarp colour development is a common postharvest problem for early harvested “Hass” avocado fruit during ripening, which affects fruit quality and consumer preference. Therefore, measures to improve “Hass” avocado fruit colour developments are of great importance in the industry. This study investigated the effectiveness of postharvest methyl jasmonate treatment to improve early matured “Hass” avocado fruit exocarp colour during ripening. The results showed that T1 (10 μmol∙L−1) and T2 (100 μmol∙L−1) MeJA treatment increased visual colour, and decreased objective colour parameters (L*, C* and h˚) during ripening when compared with control fruit. Moreover, MeJA treated “Hass” avocado fruits had lower total chlorophyll content and higher total anthocyanin and cyanidin-3-o-glucoside concentration during ripening. In conclusion, “Hass” avocado fruit post-harvest treated with either T1 (10 μmol∙L−1) or T2 (100 μmol∙L−1) MeJA concentration improved exocarp quality attributes such as colour parameters (L*, C* h˚ and visual colour) and pigments (total anthocyanin and cyanidin-3-o-glucoside) during ripening, therefore, can be recommended for avocado fruit.

关键词： Avocado Colour Methyl Jasmonate Anthocyanin cyanidin-3-o-glucoside

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The role of CD169+ macrophages in Dextran sulfate sodium-induced colitis

The role of CD169+ macrophages in Dextran sulfate sodium-ind...

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第十三届全国免疫学学术大会

作者： Yuan Xia Chunhong Qiu Cheeloo College of Medicine in Shandong University

Inflammatory bowel disease,which includes ulcerative colitis or Crohn’s disease,has been paid more attention due to their increasing incidence and a substantial increase in the risk of colorectal *** macrophages subset make an crucial role on the regulation of *** an attempt to elucidate the possible mechanism of IBD and develop new therapeutic treatments for colitis, we evaluated the pro-inflammatory effects of CD169 macrophages on Dextran sulfate sodium-induced *** observed that the injection of diphtheria toxin in CD169-DTR mice resulted in a considerable reduction of CD169 macrophages which had a significant pro-inflammatory effects in colitis in the colon, mesenteric lymph nodes and peritoneal macrophages,meanwhile,the pro-inflammatory cytokines such as IL 6,IL 1β,IL 18,TNFα,IFN r and colitis related chemokines such as CCL3,CCL8 were *** reduction of CD169 macrophages alleviated colitis significantly by reducing the percentage of Th17 cells and Th17-related cytokines, in the other hand,breaking the inhibiting effect of CCL22 which combine to Tregs,the increasing of Tregs enhanced the immune tolerance with the increasing of TGFβ and IL *** also observed that the treatment with recombinant murine CCL22 ameliorated the clinical symptoms of DSS-induced colitis and injection of cyanidin-3-o-glucoside also had a direct effect on reducing the number of CD169 macrophages and activation of macrophages in vivo and also in *** these data indicated that CD169 macrophage played an essential role on regulating mucosal inflammation,reduction of CD169 macrophages in the colon, mesenteric lymph nodes and peritoneal macrophages alleviated colitis significantly,treatment with recombinant murine CCL22 and cyanidin-3-o-glucoside had a protective effect on DSS-induced *** effects may be useful in the maintenance of immune tolerance.

关键词： CD169+ macrophage Colitis CCL22 cyanidin-3-o-glucoside

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