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Journal of Cancer Metastasis and Treatment 2020年第1期6卷 168-176页

作者： Giovanni Lo Re Paolo Doretto Francesco Lo Re Fabio Matrone Anna Ermacora Wally Marus Maria Antonietta Pizzichetta Sandro Sulfaro Medical Oncology and Immune-Related Tumors Centro di Riferimento Oncologico di Aviano(CRO)IRCCSAvianoPN 33081Italy Clinical Pathology AAS5 PordenonesePN 33170Italy Pharmacology and Clinical Toxicology University of MilanMilanMI 20129Italy Radiotherapy Unit Centro di Riferimento Oncologico di Aviano(CRO)IRCCSAvianoPN 33081Italy Internal Medicine AAS5 PordenonesePN 33170Italy Pathology AAS5 PordenonesePN 33170Italy Medical oncology and Cancer prevention Centro di Riferimento Oncologico di Aviano(CRO)IRCCSAvianoPN 33081Italy

A 70-year-old female with metastatic Cutaneous squamous cell carcinoma(cSCC)and low-grade non-Hodgkin’s lymphoma,not amenable to cisplatin combination therapy,was treated with cyclophoshamide(Cyc)-fluorouracil(FU)-interleukin-2(IL-2)in light of high tumor immunogenicity and the potential activity of this regimen.Cyc 300 mg/m^(2)and FU 500 mg/m^(2)intravenously on day 1 and IL-24.5 MIU/day on days 3-6 and 17-20 subcutaneously every 4 weeks;Carboplatin(C)AUC 2 and paclitaxel(P)85 mg/m^(2)on days 1,8 and 15±capecitabine(Cape)every 4 weeks.After partial remission(PR)of lung metastases and local control with two cycles of first therapy followed by PR with five cycles of CP±Cape,right mastectomy was performed with evidence of viable tumor.Subsequently,the patient underwent 3 cycles of chlorambucil and is alive after 13 months of follow-up.Safety and activity of chemo-immunotherapy and salvage treatment can be achieved in cSCC.

关键词： Cutaneous squamous cell carcinoma cyclophosphamide fluorouracil interleukin-2 regulatory T cells myeloid-derived suppressor cells

Risk prediction model for Cutaneous squamous cell carcinoma in adult cardiac allograft recipients

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World Journal of Transplantation 2021年第3期11卷 54-69页

作者： Nandini Nair Zhiyong Hu Dongping Du Enrique Gongora Division of Cardiology Department of Internal MedicineTexas Tech Health Sciences CenterLubbockTX 79430United States Department of Industrial Manufacturing and Systems EngineeringTexas Tech UniversityLubbockTX 79409United States Department of Cardiothoracic Surgery University of Alabama at BirminghamBirminghamAL 35233United States

BACKGROUND Heart transplant recipients are at higher risk of developing skin cancer than the general population due to the long-term immunosuppression treatment.Cancer has been reported as one of the major causes of morbidity and mortality for patients after heart transplantation.Among different types of skin cancers,Cutaneous squamous cell carcinoma(cSCC)is the most common one,which requires timely screening and better management.AIM To identify risk factors and predict the incidence of cSCC for heart transplant recipients.METHODS We retrospectively analyzed adult heart transplant recipients between 2000 and 2015 extracted from the United Network for Organ Sharing registry.The whole dataset was randomly divided into a derivation set(80%)and a validation set(20%).Uni-and multivariate Cox regression were done to identify significant risk factors associated with the development of cSCC.Receiver operating characteristics curves were generated and area under the curve(AUC)was calculated to assess the accuracy of the prediction model.Based on the selected risk factors,a risk scoring system was developed to stratify patients into different risk groups.A cumulative cSCC-free survival curve was generated using the Kaplan-Meier method for each group,and the log-rank test was done to compare the intergroup cSCC rates.RESULTS There were 23736 heart-transplant recipients during the study period,and 1827 of them have been reported with cSCC.Significant predictors of post-transplant cSCC were older age,male sex,white race,recipient and donor human leukocyte antigen(HLA)mismatch level,malignancy at listing,diagnosis with restrictive myopathy or hypertrophic myopathy,heart re-transplant,and induction therapy with OKT3 or daclizumab.The multivariate model was used to predict the 5-,8-and 10-year incidence of cSCC and respectively provided AUC of 0.79,0.78 and 0.77 in the derivation set and 0.80,0.78 and 0.77 in the validation set.The risk scoring system assigned each patient with a risk score within the range of 0-11,based on whi

关键词： Cutaneous squamous cell carcinoma Heart transplantation Cox proportional hazard model Risk assessment squamous cell carcinoma Mortality outcomes

Differential diagnosis of keratoacanthoma and Cutaneous squamous cell carcinoma

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Differential diagnosis of keratoacanthoma and cutaneous squa...

Inhibitory effect of survivin-shRNA on A431 Cutaneous squamous cell carcinoma

2018中国遗传学会第十次全国会员代表大会暨学术讨论会

作者： Li Lv Jian Li Key Laboratory of Developmental Genes and Human Disease Institute of Life SciencesSoutheast University

Keratoacanthoma（KA） is a benign tumor that is a spontaneously healing tumor. Cutaneous squamous cell carcinoma（SCC） is the second most common type of malignant tumor in skin cancer, and the number of new patients worldwide continues to rise each year. Although the prognosis of the two tumors is quite different, KA and SCC are very similar in pathology and are often difficult to distinguish. Therefore, in the clinical situation, misdiagnosis often occurs. In our study, 70 KA and SCC genomic data were analyzed by whole genome sequencing, and the measured data were compared with our previous studies using comparative genomic chips, we will find the genomic features of the two skin tumors. This study will provide a basis for the future differential diagnosis of KA and SCC, and finally achieve accurate treatment of KA and SCC skin tumors.

关键词： Keratoacanthoma Cutaneous squamous cell carcinoma Genome Differential diagnosis

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Discussion of Clinical Cases 2018年第4期5卷 1-8页

作者： Yuqin Hao Xia Liu Shuxia Kang Xin Zhang Kun Zhang Yongmeng Zhu Department of Dermatology The Third Affiliated Hospital of Inner Mongolia Medical University(Baogang Hospital)BaotouInner MongoliaChina Inner Mongolia Medical University HohehotInner MongoliaChina Reproductive Medicine Center The Third Affiliated Hospital of Inner Mongolia Medical University(Baogang Hospital)BaotouInner MongoliaChina

Objective:To observe the effect of survivin-shRNA on A431 Cutaneous squamous cell carcinoma(SCC)and explore the molecular biological mechanism of nuclear factorκB(NF-κB)in the inhibition of survivin-shRNA on cutaneous SCC.Methods:Survivin-shRNA adenovirus vector was constructed to screen out the best interference sequence.Nude mice were subcutaneously inoculated with the cultured A431 cell suspension to duplicate A431 transplanted tumor models.These mice were randomly divided into the blank control group,the rAd-EGFP negative control group,the rAd-survivin-shRNA transfection group and the Res positive control group,with 5 mice in each group.The corresponding reagents were injected into the tumors.All the mice were sacrificed on the 20th day.The tumor tissues were isolated,with tumor volume and tumor weight measured,the tumor growth curves were accordingly plotted and the tumor inhibition rate was consequently calculated.Hematoxylin-eosin(HE)staining was used to observe the cellular morphology of the tumors.TUNEL was applied to the detection of cell apoptosis.Western blot was applied to the detection of the expression of Survivin,inhibitor of NF-κB(IκB),P65,P53 and Caspase-3.Results:As to the transplanted tumors,tumor volume and tumor weight were decreased in nude mice in the rAd-survivinshRNA transfection group and the Res positive control group,in comparison with the blank control group and the rAd-EGFP negative control group,the differences were of statistical significance(pcells,degenerative liquefactive necrosis,cancer cell shrinkage and round-shape,and k

关键词： Survivin-shRNA NF-κB Cutaneous squamous cell carcinoma Inhibitory effect

Treatment Recommendations among Radiation Oncologists in the Treatment of Cutaneous squamous cell carcinoma with Perineural Invasion

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Journal of Cancer Therapy 2016年第11期7卷 824-835页

作者： Upendra Parvathaneni Madhu Shetti Daniel Berg Seesha Takagishi George E. Laramore Chrysalyne D. Schmults Anokhi Jambusaria-Pahlajani Stephen D. Hess Marvin Heyboer III Jay J. Liao University of Washington Medical Center Seattle Washington USA Brigham and Women’s Hospital Harvard Medical School Boston Massachusetts USA University of Pennsylvania Philadelphia Pennsylvania USA State University of New York (SUNY) Syracuse New York USA

Purpose: Post-operative radiotherapy (PORT) for resected Cutaneous squamous cell carcinoma (CSCC) with perineural invasion (PNI) is controversial. Therefore, we conducted a survey to review treatment recommendations among Radiation Oncologists (ROs) in the management of CSCC with PNI. Materials & Methods: In March 2011, we contacted all ROs and trainees in the US through email addresses listed in the 2009 ASTRO directory. Our web-based survey presented clinical vignettes involving Mohs micrographically resected CSCC with microscopic PNI (mPNI) or clinical PNI (cPNI). For each vignette, ROs were asked to indicate if PORT was appropriate and to further specify the dose and volume to treat. Results: Three hundred fifty two responses were completed and analyzed. The majority of ROs (72%) had over 10 years of post residency experience. 64% of the sampled ROs had a special interest in treating head and neck cancers, and 64% treated 4 or more cases per year. Approximately 95% recommended PORT for cPNI whereas 59% recommended PORT for mPNI. Post residency experience (10+ yrs vs. cutaneous non-named nerve involvement (80% vs. 60%, p = 0.001). ROs treating 8 or more cases per year (vs. <7) were more likely to recommend PORT for mPNI in immunocompromised patients (74% vs. 57%, p = 0.01). Conclusions: Our study demonstrates significant variability among ROs in the management of CSCC with mPNI. For cases of cPNI, an overwhelming majority recommended PORT. In cases of mPNI, there was no consensus for recommending PORT, although experienced practitioners had a lower threshold for offering treatment. These results indicate the need for prospective clinical studies to clarify the role of PORT in CSCC patients with mPNI.

关键词： Cutaneous squamous cell carcinoma Perineural Invasion Head and Neck Post Operative Radiation Therapy

The crucial roles of m^(6)A RNA modifications in cutaneous cancers:Implications in pathogenesis,metastasis,drug resistance,and targeted therapies

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Genes & Diseases 2023年第6期10卷 2320-2330页

作者： Cong Huang Kaoyuan Zhang Yang Guo Changbing Shen Xiaoming Liu Haiyan Huang Xia Dou Bo Yu Department of Dermatology Skin Research Institute of Peking University Shenzhen HospitalPeking University Shenzhen HospitalShenzhen Peking University-The Hong Kong University of Science and Technology Medical CenterShenzhenGuangdong 518036China Department of Dermatology Skin Research Institute of Peking University Shenzhen HospitalPeking University Shenzhen HospitalShenzhenGuangdong 518036China

N6-methyladenosine(m^(6)A)is the most abundant internal modification on RNA.It is a dynamical and reversible process,which is regulated by m^(6)A methyltransferase and m^(6)A demethylase.The m^(6)A modified RNA can be specifically recognized by the m^(6)A reader,leading to RNA splicing,maturation,degradation or translation.The abnormality of m^(6)A RNA modification is closely related to a variety of biological processes,especially the occurrence and development of tumors.Recent studies have shown that m^(6)A RNA modification is involved in the pathogenesis of skin cancers.However,the precise molecular mechanisms of m^(6)A-mediated cutaneous tumorigenesis have not been fully elucidated.Therefore,this review will summarize the biological characteristics of m^(6)A modification,its regulatory role and mechanism in skin cancers,and the recent research progress of m^(6)A-related molecular drugs,aiming to provide new ideas for clinical diagnosis and targeted therapy of cutaneous cancers.

关键词： Cutaneous squamous cell carcinoma cutaneous melanoma m6A modification m^(6)A-related drugs Target Therapy

MAPK/ERK regulation of P53 in human epidermoid carcinoma cell line A431

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Discussion of Clinical Cases 2018年第4期5卷 23-29页

作者： Yuqin Hao Chunyi Kang Xin Zhang Shuxia Kang Xia Liu Department of Dermatology The Third Affiliated Hospital of Inner Mongolia Medical University(Baogang Hospital)BaotouInner MongoliaChina Inner Mongolia Medical University HohehotInner MongoliaChina

Objective:To observe the impact of activation and inhibition of mitogen activated protein kinases(MAPK)/extracellular signalregulated protein kinase(ERK)signaling pathway on the proliferation and apoptosis of Cutaneous squamous cell carcinoma(SCC).cells and investigate the interaction mechanism between MAPK/ERK signaling pathway and tumor suppressor gene P53 in SCC.Methods:Human A431 cells were cultured and divided into MAPK/ERK inhibition groups with low-,medium-and highconcentration of inhibitors(PD98059+DMSO),MAPK/ERK activation groups with low-,medium-and high-concentration of stimuli(IGF+PBS)and blank control group(DMSO).The cell proliferation in vitro was detected by MTT assay,with the cell apoptosis detected by flow cytometry(FCM)and the protein expression of P-ERK and P53 detected by western blot in each group.Results:The A431 cell proliferation was inhibited by different concentrations of PD98059 with a clear concentration-effect and time-effect relationship(pcell proliferation was promoted by the different concentrations of IGF with a clear concentration-effect and time-effect relationship(pcells which were treated with PD98059,with a clear concentration-effect relationship(pcells were treated with IGF,also with a concentration-effect relationship(pcells were treated with PD98059.With the concentration of PD98059 going up,the decrease in P-ERK and the increase in P53 were more significant(pcells were treated with IGF.With the concentration of IGF going up,the increase in P-ERK and the decrease in P53 were more significant(p<.05).According to Pearson correlation analysis,the expression of P53 was

关键词： Cutaneous squamous cell carcinoma MAPK/ERK signaling pathway P53