Cyclophosphamide,fluorouracil and low-dose interleukin-2 and salvage combination chemotherapy in advanced cutaneous squamous cell carcinoma
作者机构：Medical Oncology and Immune-Related TumorsCentro di Riferimento Oncologico di Aviano(CRO)IRCCSAvianoPN 33081Italy Clinical PathologyAAS5 PordenonesePN 33170Italy Pharmacology and Clinical ToxicologyUniversity of MilanMilanMI 20129Italy Radiotherapy UnitCentro di Riferimento Oncologico di Aviano(CRO)IRCCSAvianoPN 33081Italy Internal MedicineAAS5 PordenonesePN 33170Italy PathologyAAS5 PordenonesePN 33170Italy Medical oncology and Cancer preventionCentro di Riferimento Oncologico di Aviano(CRO)IRCCSAvianoPN 33081Italy
出 版 物：《Journal of Cancer Metastasis and Treatment》 (癌症转移与治疗（英文版）)
年 卷 期：2020年第6卷第1期
页 面：168-176页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Cutaneous squamous cell carcinoma cyclophosphamide fluorouracil interleukin-2 regulatory T cells myeloid-derived suppressor cells
摘 要：A 70-year-old female with metastatic cutaneous squamous cell carcinoma(cSCC)and low-grade non-Hodgkin’s lymphoma,not amenable to cisplatin combination therapy,was treated with cyclophoshamide(Cyc)-fluorouracil(FU)-interleukin-2(IL-2)in light of high tumor immunogenicity and the potential activity of this regimen.Cyc 300 mg/m^(2)and FU 500 mg/m^(2)intravenously on day 1 and IL-24.5 MIU/day on days 3-6 and 17-20 subcutaneously every 4 weeks;Carboplatin(C)AUC 2 and paclitaxel(P)85 mg/m^(2)on days 1,8 and 15±capecitabine(Cape)every 4 weeks.After partial remission(PR)of lung metastases and local control with two cycles of first therapy followed by PR with five cycles of CP±Cape,right mastectomy was performed with evidence of viable tumor.Subsequently,the patient underwent 3 cycles of chlorambucil and is alive after 13 months of follow-up.Safety and activity of chemo-immunotherapy and salvage treatment can be achieved in cSCC.
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