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Skin cell-derived extracellular vesicles:a promising therapeutic strategy for cutaneous injury

Burns & Trauma 2022年第1期10卷 155-174页

作者： Min Wang Peipei Wu Jin Huang Wenhui Liu Hui Qian Yaoxiang Sun Hui Shi Jiangsu Key Laboratory of Medical Science and Laboratory Medicine Institute of Stem CellSchool of MedicineJiangsu UniversityZhenjiang 212000China Department of Clinical Laboratory The Affiliated Yixing Hospital of Jiangsu UniversityYixing 214200China Aoyang Institute of Cancer Affiliated Aoyang Hospital of Jiangsu University279 Jingang RoadSuzhouJiangsu 215100China

Wound healing refers to the healing process that occurs after the skin and other tissues are separated or damaged by internal or external *** is a complex combination of tissue regeneration,granulation tissue hyperplasia,and scar formation,and shows the synergistic effects of these *** skin damage,the environment around the wound and the cells at site of the damage respond immediately,and a range of cytokines and growth factors are *** cutaneous injury,extracellular vesicle(EV)signaling plays a vital role in the healing process via paracrine and endocrine *** are natural intercellular and inter-organ communication tools that carry various bioactive substances for message *** cells and stem cell EVs facilitate tissue repair,showing promising potential in regenerative ***,EVs derived from specific skin tissue cells,such as epidermal cells,fibroblasts,vascular endothelial cells and inflammatory cells,also play important roles in cutaneous tissue ***,we describe the characteristics of wound healing,concentrating on the production and functions of EVs derived from specific skin cells,and provide new ideas for wound therapy using EVs.

关键词： Extracellular vesicles Specific skin tissue cell cutaneous injury Wound healing

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Tailored biomedical materials for wound healing

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Burns & Trauma 2023年第1期11卷 746-764页

作者： Wenhui Liu Lihua Zu Shanzheng Wang Jingyao Li Xiaoyuan Fei Meng Geng Chunlei Zhu Hui Shi Clinical laboratory Affiliated Aoyang Hospital of Jiangsu University279 Jingang RoadSuzhouJiangsuChina Jiangsu Key Laboratory of Medical Science and Laboratory Medicine Institute of Stem CellDepartment of Laboratory MedicineSchool of MedicineJiangsu UniversityZhenjiangChina Department of Orthopaedics Zhongda HospitalMedical School of Southeast University87 Ding Jia Qiao RoadNanjingJiangsu 210009P.R.China Department of Orthopaedics Affiliated Aoyang Hospital of Jiangsu University279 Jingang RoadSuzhouJiangsuChina

Wound healing is a long-term,multi-stage biological process that mainly includes haemostatic,inflammatory,proliferative and tissue remodelling *** infection and inflammation and promoting tissue regeneration can contribute well to wound *** biomaterials offer significant advantages in wound healing because of their ability to control wound healing in time and *** how biomaterials are designed for different stages of wound healing will facilitate future personalized material tailoring for different wounds,making them beneficial for wound *** review summarizes the design approaches of biomaterials in the field of anti-inflammatory,antimicrobial and tissue regeneration,highlights the advanced precise control achieved by biomaterials in different stages of wound healing and outlines the clinical and practical applications of biomaterials in wound healing.

关键词： Wound healing Biomedical materials Advanced materials Tissue regeneration Inflammation Regeneration Antibacterial cutaneous injury

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The contradictory role of androgens in cutaneous and major burn wound healing

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Burns & Trauma 2021年第1期9卷 545-557页

作者： Huaikai Shi Kenny Cheer Ulla Simanainen Brian Lesmana Duncan Ma Jonathan J.Hew Roxanne J.Parungao Zhe Li Mark S.Cooper David J.Handelsman Peter K.Maitz Yiwei Wang Burns Research Group ANZAC Research InstituteUniversity of SydneyConcord HospitalGate3 Hospital roadConcordNSW 2139Australia Andrology ANZAC Research InstituteUniversity of SydneyConcord HospitalGate3 Hospital roadConcordNSW 2139Australia Adrenal Steroid Laboratory ANZAC Research InstituteUniversity of SydneyConcord HospitalGate3 Hospital roadConcordNSW 2139Australia Burns and Reconstructive Surgery Unit Concord HospitalGate3 Hospital roadConcordNSW 2139Australia

Wound healing is a complex process involving four overlapping phases:haemostasis,inflammation,cell recruitment and matrix *** mouse models,surgical,pharmacological and genetic approaches targeting androgen actions in skin have shown that androgens increase interleukin-6 and tumor necrosis factor-αproduction and reduce wound re-epithelization and matrix deposition,retarding cutaneous wound ***,clinical studies have shown that cutaneous wound healing is slower in men compared to ***,in major burn injury,which triggers not only local wound-healing processes but also systemic hypermetabolism,the role of androgens is poorly *** studies have claimed that a synthetic androgen,oxandrolone,increases protein synthesis,improves lean body mass and shortens length of hospital ***,the possible mechanisms by which oxandrolone regulates major burn injury have not been *** this review,we summarize the current findings on the roles of androgens in cutaneous and major burn wound healing,as well as androgens as a potential therapeutic treatment option for patients with major burn injuries.

关键词： Wound healing Androgen Mouse model Oxandrolone cutaneous injury Major burn injury

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