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curcumin preconditioning enhances the efficacy of adipose-derived mesenchymal stem cells to accelerate healing of burn wounds

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Burns & Trauma 2021年第1期9卷 272-287页

作者： Maryam Azam Hafiz Ghufran Hira Butt Azra Mehmood Ramla Ashfaq Asad M.Ilyas Muhammad R.Ahmad Sheikh Riazuddin National Centre of Excellence in Molecular Biology 87-West Canal Bank RoadUniversity of the PunjabLahorePakistan Jinnah Burn and Reconstructive Surgery Centre Maulana Shaukat Ali RdQuaid-i-Azam CampusLahorePakistan

Background:Following recent findings from our group that curcumin preconditioning augments the therapeutic efficacy of adipose-derived stem cells in the healing of diabetic wounds in rats,we aimed to investigate the regenerative effects of curcumin preconditioned adipose-derived mesenchymal stem cells(ASCs)for better recovery of acid inflicted burns in this ***:ASCs were preconditioned with 5μM curcumin for 24 hours and assessed for proliferation,migration,paracrine release potential and gene expression comparative to naive ***,the healing capacity of curcumin preconditioned ASCs(Cur-ASCs)versus naive ASCs was examined using acidic wounds in *** this,acid inflicted burns of 20 mm in diameter were made on the back of male Wistar ***,2×10^(6) cells of Cur-ASCs and naive ASCs were intradermally injected in the wound periphery(n=6)for comparison with an untreated saline ***-transplantation,wounds were macroscopically analysed and photographed to evaluate the percentage of wound closure and period of *** wound biopsies were excised and used for histological evaluation and expression analysis of wound healing markers at molecular level by quantitative PCR and western ***:We found that Cur-ASCs exhibited greater proliferation,migration and paracrine potential in ***,Cur-ASCs showed more effective recovery than naive ASCs as exhibited by gross morphology,faster wound closure and earlier ***’s trichrome and hematoxylin and eosin staining demonstrated the improved architecture of the healing burns,as evidenced by reduced infiltration of inflammatory cells,compact collagen and marked granulation in Cur-ASC treated *** these findings,molecular assessment showed significantly reduced expressions of pro-inflammatory factors(interleukin-1 beta,interleukin-6,tumor necrosis factor alpha)a with striking upsurge of an oxidative marker(superoxide dismutase 1),p

关键词： Adipose-derived stem cells curcumin preconditioning Acidic burn Wound healing

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