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The expression dynamics of IL-17 and Th17 response relative cytokines in trachea and spleen of chickens after infection with cryptosporidium baileyi

The expression dynamics of IL-17 and Th17 response relative ...

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中国畜牧兽医学会兽医寄生虫学分会第十三次学术研讨会

作者： Zhao Guanghui Cheng Wenyu Lin Qing Song Junke Yu Sanke College of Veterinary Medicine Northwest A&F University

Background cryptosporidium baileyi is the dominant cryptosporidium species in birds causing emerging health problem in the poultry industry,and is also a model to study biology of cryptosporidium spp..IL-17(also called IL-17A) is a hallmark pro-inflammatory cytokine of Th17 cells that plays an important role in several human autoimmune diseases and microbial infection disease of many animals,and it may play a role in cryptosporidium *** The present study examined the mRNA level of IL-17 and Th17 response relative cytokines in trachea and spleen of ***-infected chickens at different time points using real-time quantitative PCR(qPCR).Results All examined cytokines in trachea were up-regulated in the infected chickens compared with the uninfected control during *** *** increased IL-17 mRNA level in trachea was observed as early as 12 h post infection(pi),peaking at 24 h pi and 10 d pi,and declining *** transcription levels of IL-17 and Th17 response relative cytokines in spleen were also significantly increased at different time points during the *** IL-17 was indicated to participate in the induction of inflammation during infection of some intracellular protozoan *** results in the present study suggested that IL-17 may play a role in immunity against cryptosporidium infection,and provided basic information for determining the role of Th17 cell in cryptosporidium infection.

关键词： cryptosporidium baileyi IL-17 chicken immunity

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