The expression dynamics of IL-17 and Th17 response relative cytokines in trachea and spleen of chickens after infection with Cryptosporidium baileyi
作者单位：College of Veterinary MedicineNorthwest A&F University
会议名称：《中国畜牧兽医学会兽医寄生虫学分会第十三次学术研讨会》
会议日期：2015年
学科分类：090603[农学-临床兽医学] 09[农学] 0906[农学-兽医学]
基 金：supported by the Program for New Century Excellent Talents in University(NCET-13-0489) the Fund for Basic Scientific Research(Grant No.ZD2012010)
关 键 词：Cryptosporidium baileyi IL-17 chicken immunity
摘 要：Background Cryptosporidium baileyi is the dominant Cryptosporidium species in birds causing emerging health problem in the poultry industry,and is also a model to study biology of Cryptosporidium spp..IL-17(also called IL-17A) is a hallmark pro-inflammatory cytokine of Th17 cells that plays an important role in several human autoimmune diseases and microbial infection disease of many animals,and it may play a role in Cryptosporidium *** The present study examined the mRNA level of IL-17 and Th17 response relative cytokines in trachea and spleen of ***-infected chickens at different time points using real-time quantitative PCR(qPCR).Results All examined cytokines in trachea were up-regulated in the infected chickens compared with the uninfected control during *** *** increased IL-17 mRNA level in trachea was observed as early as 12 h post infection(pi),peaking at 24 h pi and 10 d pi,and declining *** transcription levels of IL-17 and Th17 response relative cytokines in spleen were also significantly increased at different time points during the *** IL-17 was indicated to participate in the induction of inflammation during infection of some intracellular protozoan *** results in the present study suggested that IL-17 may play a role in immunity against Cryptosporidium infection,and provided basic information for determining the role of Th17 cell in Cryptosporidium infection.