检索结果-南通市图书馆

中国神经科学学会第十届全国学术会议

作者： Shu-Jing Li Jing-Jing Zheng Xiao-Di Zhang Wan-Ying Miao Xiang Yu Institute of Neuroscience and State Key Laboratory of Neuroscience Shanghai Institutes for Biological SciencesChinese Academy of Sciences University of Chinese Academy of Sciences

Objective During the early postnatal period,neural activity,both in the form of spontaneous electrical activity and natural sensory stimulation,is critical to the formation of functional neural circuits.In addition to inducing changes within the target sensory cortex,sensory experience can also crossmodally affect other brain regions.Yet,little is known about the synaptic mechanisms underlying these crossmodal changes,especially during the first two weeks of postnatal development,at the peak of synaptogenesis.Here,we investigate the crossmodal effects of natural sensory experience during the first two postnatal weeks in the sensory cortices.Methods We used whisker-deprivation,dark-rearing and enriched environment paradigms to increase or reduce neural activity,and examined their effects on synaptic transmission and neuronal excitability in layer 2/3 pyramidal neurons,as well as on the expression of various proteins in the somatosensory and visual cortices.Results We found a novel form of plasticity in neonatal mice,where early sensory experience crossmodally regulated development of all sensory cortices.Specifically,unimodal sensory deprivation from birth through whisker-deprivation or dark-rearing reduced excitatory synaptic transmission of layer2/3 pyramidal neurons both in the correspondent sensory cortex,and crossmodally in other sensory cortices.On the other hand,increasing natural sensory experience through environment enrichment significantly increased excitatory synaptic transmission in both somatosensory and visual cortices,and also increased the protein level of post-synaptic proteins GluR2 and NR2B.Screening for changes in gene expression between normal and sensory deprived mice,we found that the mRNA level of the neuropeptide oxytocin secreted from the hypothalamus was significantly reduced in samples from sensory deprived mice.Importantly,cortical oxytocin protein level was bidirectionally regulated by sensory experience.Finally,in vivo application of oxytocin elevated excitatory synaptic transmissio

关键词： neural activity synaptic transmission sensory cortices crossmodal plasticity oxytocin

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Excitatory crossmodal Input to a Widespread Population of Primary Sensory Cortical Neurons

引用

Neuroscience Bulletin 2022年第10期38卷 1139-1152页

作者： Yuan-Jie Xiao Lidan Wang Yu-Zhang Liu Jiayu Chen Haoyu Zhang Yan Gao Hua He Zheng Zhao Zhiru Wang Institute and Key Laboratory of Brain Functional Genomics of the Chinese Ministry of Education Shanghai Key Laboratory of Brain Functional GenomicsSchool of Life SciencesEast China Normal UniversityShanghai200062China Department of Neurosurgery Third Affiliated Hospital of the Navy Military Medical UniversityShanghai200438China Department of Neuroscience University of PittsburghPittsburgh15260USA

crossmodal information processing in sensory cortices has been reported in sparsely distributed neurons under normal conditions and can undergo experience-or activity-induced plasticity.Given the potential role in brain function as indicated by previous reports,crossmodal connectivity in the sensory cortex needs to be further explored.Using perforated whole-cell recording in anesthetized adult rats,we found that almost all neurons recorded in the primary somatosensory,auditory,and visual cortices exhibited significant membrane-potential responses to crossmodal stimulation,as recorded when brain activity states were pharmacologically down-regulated in light anesthesia.These crossmodal cortical responses were excitatory and subthreshold,and further seemed to be relayed primarily by the sensory thalamus,but not the sensory cortex,of the stimulated modality.Our experiments indicate a sensory cortical presence of widespread excitatory crossmodal inputs,which might play roles in brain functions involving crossmodal information processing or plasticity.

关键词： crossmodal input crossmodal response crossmodal plasticity Sensory cortex crossmodal task Sensory loss GABAergic transmission

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：