Excitatory Crossmodal Input to a Widespread Population of Primary Sensory Cortical Neurons
作者机构：Institute and Key Laboratory of Brain Functional Genomics of the Chinese Ministry of EducationShanghai Key Laboratory of Brain Functional GenomicsSchool of Life SciencesEast China Normal UniversityShanghai200062China Department of NeurosurgeryThird Affiliated Hospital of the Navy Military Medical UniversityShanghai200438China Department of NeuroscienceUniversity of PittsburghPittsburgh15260USA
出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)
年 卷 期：2022年第38卷第10期
页 面：1139-1152页
核心收录：
学科分类：0710[理学-生物学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 071006[理学-神经生物学]
基 金：This work was supported by grants from the National Natural Science Foundation of China(31970957 and 31471078) the Shanghai Science and Technology Commission(19ZR1416600) funding from 2021-JCJQ-JJ-1089
主 题：Crossmodal input Crossmodal response Crossmodal plasticity Sensory cortex Crossmodal task Sensory loss GABAergic transmission
摘 要：Crossmodal information processing in sensory cortices has been reported in sparsely distributed neurons under normal conditions and can undergo experience-or activity-induced *** the potential role in brain function as indicated by previous reports,crossmodal connectivity in the sensory cortex needs to be further *** perforated whole-cell recording in anesthetized adult rats,we found that almost all neurons recorded in the primary somatosensory,auditory,and visual cortices exhibited significant membrane-potential responses to crossmodal stimulation,as recorded when brain activity states were pharmacologically down-regulated in light *** crossmodal cortical responses were excitatory and subthreshold,and further seemed to be relayed primarily by the sensory thalamus,but not the sensory cortex,of the stimulated *** experiments indicate a sensory cortical presence of widespread excitatory crossmodal inputs,which might play roles in brain functions involving crossmodal information processing or plasticity.
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