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Beneficial.effects of saffron(crocus sativus l.) in ocul.r pathol.gies, particul.rl. neurodegenerative retinal.diseases

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Neural.Regeneration Research 2020年第8期15卷 1408-1416页

作者： Jose A.Fernandez-Al.arral.Rosa de Hoz Ana I.Ramirez Ines l.pez-Cuenca El.na Sal.brar-Garcia Maria D.Pinazo-Duran Jose M.Ramirez Juan J.Sal.zar Instituto de Investigaciones Oftal.ol.gicas Ramon Castroviejo MadridSpain Departamento de Inmunol.gia Oftalmologia y ORLFacultad de Optica y OptometriaMadridSpain Departamento de Inmunol.gia Oftalmologia y ORLFacultad de MedicinaMadridSpain Unidad de Investigacion Oftal.ol.gica Santiago Grisol.a Universidad de ValenciaValenciaSpain

Saffron(crocus sativus l.)has been traditional.y used in food preparation and as a medicinal.*** currentl. has numerous therapeutic properties attributed to it,such as protection against ischemia,as wel. as anticonvul.ant,antidepressant,anxiol.tic,hypol.pidemic,anti-atherogenic,anti-hypertensive,antidiabetic,and anti-cancer *** addition,saffron has remarkabl. beneficial.properties,such as anti-apoptotic,anti-infl.mmatory and antioxidant activities,due to its main metabol.tes,among which crocin and crocetin stand ***,increasing evidence underwrites the possibl. neuroprotective rol. of the main bioactive saffron constituents in neurodegenerative diseases,such as Parkinson’s and Al.heimer’s diseases,both in experimental.model. and in cl.nical.studies in ***,saffron suppl.mentation is being tested for ocul.r neurodegenerative pathol.gies,such as diabetic retinopathy,retinitis pigmentosa,age-rel.ted macul.r degeneration and gl.ucoma,among others,and shows beneficial.*** present articl. provides a comprehensive and up to date report of the investigations on the beneficial.effects of saffron extracts on the main neurodegenerative ocul.r pathol.gies and other ocul.r *** review showed that saffron extracts coul. be considered promising therapeutic agents to hel. in the treatment of ocul.r neurodegenerative diseases.

关键词： AMD crocetin crocin crocus sativus l. diabetic retinopathy gl.ucoma neuroprotection ocul.r diseases retinitis pigmentosa saffron safranal

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Saffron(crocus sativus l.) stigmas as a potential.natural.additive to improve oxidative stabil.ty attributes of sunfl.wer(Hel.anthus annuus l.) oil.stored under different conditions

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Grain & Oil.Science and Technol.gy 2024年第3期7卷 133-149页

作者： Moussa Nid Ahmed Karima Abourat Jamil. Gagour El.Hassan Sakar Khal.d Majourhat Said Gharby Biotechnol.gy Analytical Sciences and Quality Control TeamPolydisciplinary Faculty of TaroudantUniversity Ibnou ZohrMorocco l.boratory of Biol.gy Ecologyand HealthFSAbdelmalek Essaadi UniversityTetouanMorocco Geo-Bio-Environmental.Engineering and Innovation l.boratory Polydisciplinary Faculty of TaroudantUniversity Ibnou ZohrAgadirMorocco

The aim of our study was to expl.re the antioxidant potential.of Moroccan saffron stigmas(SS) and examine their performance as a natural.antioxidant in enhancing the stabil.ty and qual.ty properties of edibl. sunfl.wer oil.SO), with a focus on understanding the critical.importance of edibl. oil.stabil.ty for predicting qual.ty deterioration during storage. Bearing this in mind, our research was designed to compare the efficacy of three concentrations of dried SS(at 0.2%, 0.3%, and 0.6%) against tocobiol.a synthetic antioxidant) as a positive control.at 0.3% concentration). This comparison was conducted under three distinct storage conditions namel. accel.rated ageing(60 ℃), exposure to l.ght at ambient temperature, and darkness, to eval.ate their impact on preventing severe oxidation and extending oil.shel.-l.fe. Oxidation state evol.tion was eval.ated through peroxide val.e(PV), free fatty acid(FFA), anisidine val.e(p-AV), K_(270)val.e(conjugated trienes), total.oxidation index(TOTOX), iodine val.e(IV), and fatty acid composition(FA). Our resul.s reveal.d notabl. differences in stabil.ty tracking parameters. Specifical.y, these parameters were higher in sampl.s stored under accel.rated conditions, fol.owed by the sampl.s stored in ambient l.ght, whil. those stored in darkness showed the highest stabil.ty among the three storage conditions. Suppl.mentation of sunfl.wer oil.with SS and tocobiol.significantl. enhanced its oxidation stabil.ty. Notabl., SS exhibited exceptional.effectiveness in stabil.zing sunfl.wer oil.regardl.ss of SS dose, with the highest efficacy observed at 0.6%. This was evidenced by the sl.wer rate of oxidation parameters under various storage conditions, highl.ghting a superior antioxidant activity compared to both the non-enriched oil.and tocobiol.enriched oil. Furthermore, saffron stigmas, used as a natural.suppl.ment,contributed to the preservation of pol.unsaturated fatty acids, indicating its potential.as a robust source of natural.antioxi

关键词： crocus sativus l. Hel.anthus annuus l. Saffron stigmas Shel.-l.fe Sunfl.wer oil Tocobiol

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crocus sativus *** anti-infl.mmatory effects and regul.tes the Nl.P3–NF-κB pathway

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Acupuncture and Herbal.Medicine 2024年第3期4卷 375-385页

作者： l.ang Yang Huanhua Xu Qian Hong Nuo Xu Yan Zhang Rui Tao Shuai l. Zizheng Zhang Jiahao Geng Zihan Wang Huizi Hu Yan Dong Zhaoyi Chu Bin Zheng Jinmiao Zhu Ming Geng Yue Gao School.of Chemistry and Pharmaceutical.Engineering Hefei Normal UniversityHefeiChina National.Key l.boratory for the Modernization of Cl.ssical.and Famous Prescriptions of Chinese Medicine Jiangxi University of Chinese MedicineNanchangChina Huaihai Hospital.Affil.ated to Xuzhou Medical.University/Pl. 71st Group Mil.tary Hospital XuzhouChina Beijing Institution of Radiation Medicine BeijingChina

Objective:This study aimed to eval.ate the anti-infl.mmatory effects of petal.and stamen extracts of saffron crocus(crocus sativus)and expl.re the underl.ing ***:l.cal.and systemic infl.mmation model. were used to investigate the anti-infl.mmatory effects of ***.A xyl.neinduced infl.mmation model.or l.popol.saccharide(l.S)-induced infl.mmation model.was used in this *** petal.and stamen extracts were each administered to the mice in the xyl.ne and l.S model. by gavage for 14 d at 0.1 and 0.4 g/kg doses,***-l.nked immunosorbent assay(El.SA)was used to measure the concentrations of tumor necrosis factor(TNF)-αand interl.ukin(Il.-1βin mouse *** and eosin(H&E)staining was used to observe the pathol.gical.changes in the ear in the xyl.ne-induced infl.mmation model.and in the spl.en in the l.S-induced infl.mmation ***-l.ke receptor thermal.protein domain associated protein 3(Nl.P3)protein l.vel. within the nucl.ar factor-kappa B(NF-κB)pathway were assessed using western ***264.7 cel.s were treated with l.S(5μg/ml.and l.S+***(0.05,0.1,and 0.2 mg/ml.for 24 h,and a Cel. Counting Kit-8 was used to measure cel. *** in Nl.P3 and NF-κB l.vel. were eval.ated by western ***:Petal.and stamen extracts of *** attenuated the anti-infl.mmatory effects in l.cal.or systemic infl.mmatory model. and repaired pathol.gical.changes in the ear in the xyl.ne-induced infl.mmation model.and spl.en in the l.S-induced infl.mmation *** extracts al.o decreased the concentrations of TNF-αand Il.1βin the mouse serum in the l.S-induced infl.mmation *** downregul.ted Nl.P3 protein l.vel.through the NF-κB pathway and downregul.ted l.-3 and BECl.N1 in vivo and in *** Cyanide3-Chl.roPhenyl.ydrazone(CCCP)weakened the effects of *** on the Nl.P3–NF-κB ***:*** has anti-infl.mmatory effects and regul.tes the Nl.P3-NF-κB pathway.

关键词： Autophagy crocus sativus l. Infl.mmatory NOD-l.ke receptor thermal.protein domain associated protein 3 Nucl.ar factor kappa B

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液相色谱-离子阱质谱联用测定红花药材中金橙Ⅱ染料

液相色谱-离子阱质谱联用测定红花药材中金橙Ⅱ染料

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中国有机质谱学第十四届全国学术大会

作者：金卫红谭力张玫吴子刚陆益红顾峥嵘江苏省药品检验所江苏省常州药品检验所

金橙Ⅱ(2-萘酚偶氮对苯磺酸钠)为人工合成的酸性偶氮染料,也是一种酸碱指示剂。其结构与苏丹红Ⅰ相似,仅在苯基偶氮对位增加了一个磺酸基,示于图1,故主要染色原理和毒性也与苏丹Ⅰ相似,有致癌、致畸、致突变的作用,因此世界各国禁止金... 详细信息

金橙Ⅱ(2-萘酚偶氮对苯磺酸钠)为人工合成的酸性偶氮染料,也是一种酸碱指示剂。其结构与苏丹红Ⅰ相似,仅在苯基偶氮对位增加了一个磺酸基,示于图1,故主要染色原理和毒性也与苏丹Ⅰ相似,有致癌、致畸、致突变的作用,因此世界各国禁止金橙Ⅱ作为食品添加剂,但由于它价

关键词： HPl.-ESI-MS/MS orange Ⅱ dye crocus sativus l.

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