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crimped nanofiber scaffold mimicking tendon-to-bone interface for fatty-infiltrated massive rotator cuff repair

Bioactive Materials 2022年第10期7卷 149-161页

作者： Liren Wang Tonghe Zhu Yuhao Kang Jianguang Zhang Juan Du Haihan Gao Sihao Chen Jia Jiang Jinzhong Zhao Department of Sports Medicine Department of OrthopedicsShanghai Institute of Microsurgery on ExtremitiesShanghai Jiao Tong University Affiliated Sixth People’s HospitalNo.600 Yishan RoadShanghai200233China Regenerative Sports Medicine and Translational Youth Science and Technology Innovation Workroom Shanghai Jiao Tong University School of MedicineNo.227 South Chongqing RoadShanghai200025China Department of Medgen Group Research Laboratory 18 Qinglan 3 RdShenzhen518118China Biofunctional Materials Research Group College of Chemistry and Chemical EngineeringMultidisciplinary Center for Advanced MaterialsInstitute of Advanced StudiesShanghai University of Engineering ScienceNo.333 Longteng RdShanghai201620China Shanghai Jiao Tong University School of Medicine No.227 South Chongqing RoadShanghai200025China Regenerative Sports Medicine Lab of the Institute of Microsurgery on Extremities Shanghai Jiao Tong University Affiliated Sixth People’HospitalNo.600 Yishan RoadShanghai200233China

Electrospun fibers,with proven ability to promote tissue regeneration,are widely being explored for rotator cuff ***,without post treatment,the microstructure of the electrospun scaffold is vastly different from that of natural extracellular matrix(ECM).Moreover,during mechanical loading,the nanofibers slip that hampers the proliferation and differentiation of migrating stem ***,electrospun nanofiber scaffolds,with crimped nanofibers and welded joints to biomimic the intricate natural microstructure of tendon-to-bone insertion,were prepared using poly(ester-urethane)urea and gelatin via electrospinning and double crosslinking by a multi-bonding network densification *** crimped nanofiber scaffold(CNS)features bionic tensile stress and induces chondrogenic differentiation,laying credible basis for in vivo *** repairing a rabbit massive rotator cuff tear using a CNS for 3 months,the continuous translational tendon-to-bone interface was fully regenerated,and fatty infiltration was simultaneously *** of micro-CT,μCT was employed to visualize the integrity and intricateness of the three-dimensional microstructure of the CNS-induced-healed tendon-to-bone interface at an ultra-high resolution of less than 1μ*** study sheds light on the correlation between nanofiber post treatment and massive rotator cuff repair and provides a general strategy for crimped nanofiber preparation and tendon-to-bone interface imaging characterization.

关键词： Massive rotator cuff tear Fatty infiltration Nanofiber scaffold crimped structure Tendon-to-bone interface

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