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Parametric analysis of craniocerebral injury mechanism in pedestrian trafficaccidents based on finite element methods

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Chinese Journal of Traumatology 2024年第4期27卷 187-199页

作者： Jin-Ming Wang Zheng-Dong Li Chang-Sheng Cai Ying Fan Xin-Biao Liao Fu Zhang Jian-Hua Zhang Dong-Hua Zou Academy of Forensic Science Shanghai Key Laboratory of Forensic MedicineKey Laboratory of Forensic ScienceMinistry of JusticeShanghai Forensic Service PlatformShanghai200063China School of Forensic Medicine Guizhou Medical UniversityGuiyang550004China Key Laboratory of Forensic Pathology Ministry of Public Security PR ChinaGuangzhou510050China

Purpose:The toughest challenge in pedestrian traffic accident identification lies in ascertaining *** study aimed to systematically simulate and parameterize 3 types of craniocerebral injuryincluding impact injury,fall injury,and run-over injury,to compare the injury response outcomes ofdifferent injury ***:Based on the total human model for safety(THUMS)and its enhanced human model THUMShollow structures,a total of 84 simulations with 3 injury manners,different loading directions,andloading velocities were *** Mises stress,intracranial pressure,maximum principal strain,cumulative strain damage measure,shear stress,and cranial strain were employed to analyze the injuryresponse of all areas of the *** examine the association between injury conditions and injuryconsequences,correlation analysis,principal component analysis,linear regression,and stepwise linearregression were ***:There is a significant correlation observed between each criterion of skull and brain injury(p40 km/h),the Von Mises stress on the skull waswith a high possibility exceed the threshold for skull fracture(100 MPa).When falling and makingtemporal and occipital contact with the ground,the opposite side of the impacted area experienceshigher frequency stress concentration than contact at other ***-over injuries tend to have amore comprehensive craniocerebral injury,with greater overall deformation due to more adequate kinetic energy *** mean value of maximum principal strain of brain and Von Mises stress ofcranium at run-over condition are 1.39 and 403.8 MPa,while they were 1.31,94.11 MPa and 0.64,120.5 MPa for the impact and fall conditions,*** impact velocity also plays a significant rolein craniocerebral injury in impact and fall loading conditions(the p

关键词： craniocerebral injury Finite element injury mechanism Traffic accident Biomechanism Forensic practice

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Impact of failure mode and effects analysis-based emergency management on the effectiveness of craniocerebral injury treatment

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World Journal of Clinical Cases 2022年第2期10卷 554-562页

作者： Xiao-Lan Shao Ya-Zhou Wang Xiong-Hui Chen Wen-Juan Ding Department of Emergency Surgery Ward 48 First Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina

BACKGROUND craniocerebral injuries encompass brain injuries,skull fractures,cranial soft tissue injuries,and similar ***,the incidence of craniocerebral injuries has increased dramatically due to the increased numbers of traffic accidents and aerial work injuries,threatening the physical and mental health of *** To investigate the impact of failure modes and effects analysis(FMEA)-based emergency management on craniocerebral injury treatment *** Eighty-four patients with craniocerebral injuries,treated at our hospital from November 2019 to March 2021,were selected and assigned,using the random number table method,to study(n=42)and control(n=42)*** in the control group received conventional management while those in the study group received FMEA theory-based emergency management,based on the control ***-and post-interventions,details regarding the emergency situation;levels of inflammatory stress indicators[Interleukin-6(IL-6),C-reactive protein(CRP),and procalcitonin(PCT)];incidence of complications;prognoses;and satisfaction regarding patient care were evaluated for both *** For the study group,the assessed parameters[pre-hospital emergency response time(9.13±2.37 min),time to receive a consultation(2.39±0.44 min),time needed to report imaging findings(1.15±4.44 min),and test reporting time(32.19±6.23 min)]were shorter than those for the control group(12.78±4.06 min,3.58±0.71 min,33.49±5.51 min,50.41±11.45 min,respectively;P0.05);post-intervention serum indicator levels were lower in both groups than pre-intervention ***,serum levels of IL-6(17.35±5.33 pg/mL),CRP(2.27±0.56 mg/L),and PCT(0.22±0.07 ng/mL)were low

关键词： craniocerebral injury Failure modes and effects analysis theory Emergency management Treatment effect

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craniocerebral injury promotes the repair of peripheral nerve injury

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Neural Regeneration Research 2014年第18期9卷 1703-1708页

作者： Wei Wang Jun Gao Lei Na Hongtao Jiang Jingfeng Xue Zhenjun Yang Pei Wang Department of Hand and Foot Surgery Affiliated Hospital of Chengde Medical College Department of Postgraduate Chengde Medical College Department of Anatomy Chengde Medical College

The increase in neurotrophic factors after craniocerebral injury has been shown to promote fracture healing. Moreover, neurotrophic factors play a key role in the regeneration and repair of peripheral nerve. However, whether craniocerebral injury alters the repair of peripheral nerve injuries remains poorly understood. Rat injury models were established by transecting the left sciatic nerve and using a free-fall device to induce craniocerebral injury. Compared with sciat- ic nerve injury alone after 6-12 weeks, rats with combined sciatic and craniocerebral injuries showed decreased sciatic functional index, increased recovery of gastrocnemius muscle wet weight, recovery of sciatic nerve ganglia and corresponding spinal cord segment neuron mor- phologies, and increased numbers of horseradish peroxidase-labeled cells. These results indicate that craniocerebral injury promotes the repair of peripheral nerve injury.

关键词： nerve regeneration craniocerebral injury peripheral nerve sciatic nerve sciatic nerveinjury nerve repair horseradish peroxidase tracer technique neural regeneration

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Early hyperbaric oxygen therapy inhibits aquaporin 4 and adrenocorticotropic hormone expression in the pituitary gland of rabbits with blast-induced craniocerebral injury

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Neural Regeneration Research 2012年第22期7卷 1729-1735页

作者： Jian Huo Jiachuan Liu Jinbiao Wang Yongming Zhang Chunlin Wang Yanyan Yang WenjiangSun Shaonian Xu Department of Neurosurgery the 105 Hospital of Chinese PLAHefei 230032Anhui ProvinceChina

In the present study, rabbits were treated with hyperbaric oxygen for 1 hour after detonator-blastinduced craniocerebral injury. Immunohistochemistry showed significantly reduced aquaporin 4 expression and adrenocorticotropic hormone expression in the pituitary gland of rabbits with craniocerebral injury. Aquaporin 4 expression was positively correlated with adrenocorticotropic hormone expression. These findings indicate that early hyperbaric oxygen therapy may suppress adrenocorticotropic hormone secretion by inhibiting aquaporin 4 expression.

关键词： hyperbaric oxygen blast-induced injury craniocerebral injury aquaporin 4 pituitary gland adrenocorticotropic hormone

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Changes in circulating inflammatory cells and the relationship to secondary brain injury in patients with craniocerebral injury

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Neural Regeneration Research 2008年第8期3卷 867-870页

作者： Xiaoping Tang Tao Zhang Yuanchuan Wang Hua Peng Ling Feng Jian Qi Wenguo Tang Zhangyang Gou Dingyong Yu Renguo Luo Department of Neurosurgery Affiliated Hospital of North Sichuan Medical University Nanchong 637000 Sichuan Province China

BACKGROUND：Recent studies have indicated that reactive encephalitis plays an important role in secondary tissue damage after craniocerebral injury. OBJECTIVE： To observe changes in white blood cells （WBC） and polymorphonuclear neutrophils （PMN） in peripheral blood, and to determine their role in secondary brain insult in patients with craniocerebral injury. DESIGN, TIME AND SETTING： A case-control study at the Department of Neurosurgery of the Affiliated Hospital North Sichuan University of Medical Sciences between August 2007 and May 2008. PARTICIPANTS： Sixty-three patients, admitted within 24 hours after craniocerebral injury and who received no surgery, were included in the study. The cohort consisted of 41 males and 22 females, aged 9–72 years, with an average age of 42 years. Ten healthy volunteers, selected from the Department of Neurosurgery, were designated as the control group. METHODS： WBC and PMN from the peripheral blood were measured 0, 24, 48, 72, and 168 hours after admission to hospital. The Glasgow coma scale, area of cerebral hemorrhage, and degree of brain edema were simultaneously determined. The Glasgow outcome scale was evaluated six months after injury. The relationship between changes in WBC and PMN were analyzed. Sixty-three patients were divided into 0, 24, 48, 72, and 168 hours groups, with admission time to hospital as the determining factor. As controls, WBC and PMN of peripheral blood were also detected in 10 healthy volunteers. MAIN OUTCOME MEASURES： The main outcome measures were WBC and PMN counts in the peripheral blood at 0, 24, 48, 72, and 168 hours after admission to hospital, the mutual relationship between GCS, WBC and PMN, and changes in brain hemorrhage volume and edema size. RESULTS： WBC peaked at 24 hours after injury, and PMN peaked at 48 hours after injury （P 〈 0.01）. These measures negatively correlated to the Glasgow coma scale （r = -0.657, -0.541, respectively, P 〈 0.05）. In patients with Glasgow coma sale 〈 8, WBC and

关键词： craniocerebral injury inflammatory cells secondary brain injury

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Treatment of singultus following craniocerebral injury Intranasal cavity drip infusion versus intramuscular injection of aminazine

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Neural Regeneration Research 2007年第10期2卷 621-624页

作者： Shu mao Yang Ming Zhao Anguo Han Dazhao Yang Bo Su Xuxiang Sun Department of Neurosurgery Xi＇an Aerospace General HospitalXi＇an 710100Shanxi ProvinceChina Department of Neurosurgery First Affiliated Hospital of General Hospital of Chinese PLABeijing 100037China Department of Neurosurgery Third Hospital of Datong Tongmei GroupDatong 037017Shanxi ProvinceChina

craniocerebral injury always accompanies with singultus, while frequent singultus may cause increased intracranial pressure. Simultaneously, respiratory alkalosis and cerebral hypoxia induced by respiratory disorder may aggravate craniocerebral injury. OBJECTIVE： To observe the therapeutic effects of intranasal cavity drip infusion of aminazine and intramuscular injection on singultus following craniocerebral injury. DESIGN： Contrast observation. SETTING： Department ofNeurosurgery, Xi＇an Aerospace General Hospital. PARTICIPANTS： A total of 102 patients with singultus following craniocerebral injury were selected from the Department of Neurosurgery, Xi＇an Aerospace General Hospital from June 2001 to June 2006. Patients with craniocerebral injury were diagnosed with CT examination and randomly divided into nasal cavity medication group （n =62） and intramuscular injection group （n =40）. There were 44 males and 18 females in the nasal cavity medication group and their mean age was （33±4） years; while, there were 26 males and 14 females in the intramuscular injection group and their mean age was （29±4） years. All patients and their relatives provided the confirmed consent. METHODS： Patients in the nasal cavity medication group were slowly dripped aminazine solution into bilateral nasal cavity with the dosage of 12.5 mg （0.5 mL）. Patients who had no obvious effect or had mild improvement received the treatment once every 6 hours. The treatment was stopped if symptoms were also observed after the fifth medication. In addition, patients in the intramuscular injection group received intramuscular injection of 50 mg aminazine. Patients who had no obvious effect or had mild improvement received the treatment once every 6 hours. The treatment was changed if symptoms were also observed after the fifth medication. MAIN OUTCOME MEASURES： Therapeutic effects of different medications in the two groups. RESULTS： All 102 patients were involved in the final analysis. Effective rate in

关键词： craniocerebral injury singultus aminazine

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Clinical diagnosis and treatment of abdominal visceral injury complicated by craniocerebral injury

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Chinese Journal of Traumatology 2006年第2期9卷 105-107页

作者： BAO Shi-ting WANG San-ming LIN Mu-sheng Department of Hepatobiliary Surgery Affiliated Hospital of Guangdong Medical College Zhanjiang Guangdong 524001China

Objective ： To improve the cure rate of patients with abdominal visceral injury complicated by craniocerebral injury. Methods： Clinical data of 176 cases of abdominal visceral injury complicated by craniocerebral injury were retrospectively analyzed. Results： In this series, 44 cases died and the mortality was 25.0%. The main cause of death is abdominal visceral injury combined with shock and severe craniocerebral injury. Conclusions： It is essential to improve the cure rate by accurate diagnosis at early stage. Abdominal paracentesis and CT should be performed promptly and dynamically. Priority should be given to the treatment of life-threatening injuries.

关键词： Abdominal injury craniocerebral injury Diagnosis Therapy

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Intentional Penetrating craniocerebral injury Caused by a Nail: Clinical Presentation and Management of Three Cases

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Open Journal of Modern Neurosurgery 2020年第4期10卷 458-463页

作者： Olatoundji Holden Fatigba Luphin Hodé Christian Padonou Unit of Neurosurgery Faculty of Medicine of Parakou University Parakou Benin Unit of Neurosurgery Teaching Hospital of Hubert Koutoukou Maga Cotonou Benin

The authors report on their experience in the medical and surgical management of three cases of penetrating craniocerebral injuries caused by a nail. In all three cases, it was an aggression. Two of the three patients were male. The cranial locations affected were respectively left parietal, right temporal and right frontal. The Glasgow coma score (GCS) was between 9 and 13. None of the patients had a motor deficit. A plain skull radiographs was performed for each patient. All patients underwent surgery and all received antibiotic therapy and tetanus vaccination. In two cases, post-operative outcome was simple. Recovery was complete without sequelae. The patient with a GCS of 9 died the day after surgery.

关键词： Penetrating injury craniocerebral injury Nail

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An analysis of the therapy consisting of electroacupuncture and hyperbaric oxygen to patients with cognitive impairments caused by craniocerebral injury

An analysis of the therapy consisting of electroacupuncture ...

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中国康复医学会第八届全国康复治疗学术年会

作者： Wang Wenchun,Guo Xiaoyan,Lu Yinghua,Pang Rizhao,Fu Xi,Tian Tian,Bai Ling Dai Guoqiang,Zhang Anren (Department of Rehabilitation Medicine,Chinese PLA General Hospital of Chengdu Military Region, Chengdu,610083)

＜正＞Objective:To discuss and analyse the therapeutic effect of the treatment combined with electroacupuncture and hyperbaric oxygen to patients with cognitive impairents caused by craniocerebral ***:210 cases of craniocerebral injury with cognitive impairments were randomly divided into three groups:Group A（electroacupuncture therapy only）,Group B（hyperbaric oxygen therapy only） and Group C（therapy consisting of both electroacupuncture and hyperbaric oxygen）.Before and after the treatment,assessment of cognitive functions and activities of daily living（ADL） of all the patients was achieved by Loewenstein and Modified Barthel Index（MBI）.Results:The progress in those three groups evaluated by Loewenstein and MBI revealed significant differences（P＜0.05）,and especially the improvement of cognitive functions and ADL in Group C was more obvious than odier two groups（P＜0.01）. Conclusion:The treatment of electroacupuncture in harmony with hyperbaric oxygen therapy can play a more effective role on the advancement of cognitive impairments and activities of daily living after craniocerebral injury.

关键词： craniocerebral injury Cognitive impairments Electroacupuncture Hyperbaric oxygen therapy Cognitive functions

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Correlation study of relative parameters of intracranial pressure and prognosis of patient with craniocerebral injury

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Discussion of Clinical Cases 2019年第4期6卷 20-24页

作者： Laixing Liu Yixin Deng Fuquan Liu Lei Chen Dexi Li Xiangyi Wang Department of Neurosurgery Baogang HospitalBaotouInner MongoliaChina Department of Medical Science Inner Mongolia Medical UniversityHohhotInner MongoliaChina

Objective:To analyze the correlation of the relative parameters of intracranial pressure to the prognosis in patients with craniocerebral ***:The clinical data of 80 patients with closed craniocerebral injury were retrospectively analyzed,and all of these patients underwent conventional examinations of arterial blood pressure and intracranial *** DCR system was used to monitor relative parameters of intracranial pressure from *** to the score of Glasgow outcome scale(GOS)upon discharge,they were divided into favorable prognosis group(GOSⅢ-Ⅴ,n=46)and unfavorable prognosis group(GOSⅠ-Ⅱ,n=34).The relative parameters of intracranial pressure of two groups were compared so as to analyze the correlation of the prognosis in patients to ICP-related ***:Pressure reactivity index(PRx)and intracranial pressure(ICP)of favorable prognosis group were significantly higher than those of unfavorable prognosis group(t=12.27,t=5.22,pcraniocerebral injury are risk factors for the prognosis ***,to monitor the above-mentioned indicators has an important clinical value for assessing the prognosis of craniocerebral injury.

关键词： Influence factor Prognosis Pressure reactivity index Continuous invasive ICP monitoring craniocerebral injury

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