Craniocerebral injury promotes the repair of peripheral nerve injury

作     者：Wei Wang Jun Gao Lei Na Hongtao Jiang Jingfeng Xue Zhenjun Yang Pei Wang 

作者机构：Department of Hand and Foot SurgeryAffiliated Hospital of Chengde Medical College Department of PostgraduateChengde Medical College Department of AnatomyChengde Medical College 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2014年第9卷第18期

页      面：1703-1708页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：supported by a grant from Hebei Provincial Science and Technology Department in China No.142777105D 13277772D 

主　　题：nerve regeneration craniocerebral injury peripheral nerve sciatic nerve sciatic nerveinjury nerve repair horseradish peroxidase tracer technique neural regeneration 

摘      要：The increase in neurotrophic factors after craniocerebral injury has been shown to promote fracture healing. Moreover, neurotrophic factors play a key role in the regeneration and repair of peripheral nerve. However, whether craniocerebral injury alters the repair of peripheral nerve injuries remains poorly understood. Rat injury models were established by transecting the left sciatic nerve and using a free-fall device to induce craniocerebral injury. Compared with sciat- ic nerve injury alone after 6-12 weeks, rats with combined sciatic and craniocerebral injuries showed decreased sciatic functional index, increased recovery of gastrocnemius muscle wet weight, recovery of sciatic nerve ganglia and corresponding spinal cord segment neuron mor- phologies, and increased numbers of horseradish peroxidase-labeled cells. These results indicate that craniocerebral injury promotes the repair of peripheral nerve injury.