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cow’s milk-induced gastrointestinal disorders:From infancy to adulthood

World Journal of Clinical Pediatrics 2022年第6期11卷 437-454页

作者： Mohammed Al-Beltagi Nermin Kamal saeed Adel salah Bediwy Reem Elbeltagi Department of Pediatrics Faculty of MedicineTanta UniversityTanta 31511AlgharbiaEgypt Department of Pediatrics University Medical CenterArabian Gulf UniversityManama 26671Bahrain Department of Pathology Microbiology SectionSalmaniya Medical ComplexManama 26671Bahrain Department of Pathology Microbiology SectionRoyal College of Surgeons in Ireland-BahrainBusaiteen 15503MuharraqBahrain Department of Chest Diseases Faculty of MedicineTanta UniversityTanta 31527AlgharbiaEgypt Department of Chest Diseases University Medical CenterArabian Gulf UniversityManama 26671Bahrain Department of Medicine The Royal College of Surgeons in Ireland-BahrainBusiateen 15503MuharraqBahrain

milk is related to many gastrointestinal disorders from the cradle to the grave due to the many milk ingredients that can trigger gastrointestinal discomfort and ***’s milk protein allergy(CMPA)is the most common food allergy,especially in infancy and childhood,which may persist into *** are three main types of CMPA;immunoglobulin E(IgE)-mediated CMPA,non-IgEmediated CMPA,and mixed *** appears before the first birthday in almost all *** may start even during the neonatal period and can be severe enough to simulate neonatal ***(often non-IgE mediated)can present with symptoms of gastroesophageal reflux,eosinophilic esophagitis,hemorrhagic gastritis,food protein-induced protein-losing enteropathy,and food protein-induced enterocolitis *** CMPAs are benign and outgrown during *** is not as common in adults as in children,but when present,it is usually severe with a protracted *** intolerance is a prevalent condition characterized by the development of many symptoms related to the consumption of foods containing *** intolerance has four typical types:Developmental,congenital,primary,and *** intolerance and CMPA may be the underlying pathophysiologic mechanisms for many functional gastrointestinal disorders in children and *** are also common in inflammatory bowel *** consumption may have preventive or promoter effects on cancer *** may also become a source of microbial infection in humans,causing a wide array of diseases,and may help increase the prevalence of antimicrobial *** editorial summarizes the common milk-related disorders and their symptoms from childhood to adulthood.

关键词： cow’s milk Adults Children Functional gastrointestinal disorders cow’s milk protein allergy Lactose intolerance,Inflammatory bowel disease Zoonosis

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