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cortical thickness abnormalities in patients with first episode psychosis:a meta-analysis of psychoradiologic studies and replication in an independent sample

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Psychoradiology 2021年第4期1卷 185-198页

作者： Keren Wen Youjin Zhao Qiyong Gong Ziyu Zhu Qian Li Nanfang Pan Shiqin Fu Joaquim Radua Eduard Vieta Poornima Kumar Graham J.Kemp Bharat B.Biswal Huaxi MR Research Center(HMRRC) Department of RadiologyWest China Hospital of Sichuan UniversityChengdu 610041SichuanChina Research Unit of Psychoradiology Chinese Academy of Medical SciencesChengdu 610041SichuanChina Functional and Molecular Imaging Key Laboratory of Sichuan Province Chengdu 610041SichuanChina Institut d’Investigacions Biom`ediques August Pi i Sunyer(IDIBAPS) Mental Health Research Networking Center(CIBERSAM)Barcelona 08036CataloniaSpain Centre for Psychiatric Research and Education Department of Clinical NeuroscienceKarolinska InstitutetSolna 171-77StockholmSweden Department of Psychosis Studies Institute of PsychiatryPsychology and NeuroscienceKing’s College LondonLondon WC2R 2LSUK Barcelona Bipolar Disorders and Depressive Unit Hospital ClinicInstitute of NeurosciencesUniversity of BarcelonaBarcelona 08036CataloniaSpain Center for Depression Anxiety and Stress ResearchMcLean HospitalBelmont 02478MAUSA Department of Psychiatry Harvard Medical SchoolBoston 02115MAUSA Liverpool Magnetic Resonance Imaging Centre(LiMRIC)and Institute of Life Course and Medical Sciences University of LiverpoolLiverpool L693GEUK Department of Biomedical Engineering New Jersey Institute of TechnologyNewark 07102NJUSA The Clinical Hospital of Chengdu Brain Science Institute MOE Key Laboratory for NeuroinformationUniversity of Electronic Science and Technology of ChinaChengdu 610054SichuanChina

Background:Abnormalities of cortical thickness(CTh)in patients with their first episode psychosis(FEP)have been frequently reported,but findings are ***:To define the most consistent CTh changes in patients with FEP by meta-analysis of publishedwholebrain ***:The meta-analysis used seed-based dmapping(SDM)software to obtain the most prominent regional CTh changes in FEP,and meta-regression analyses to explore the effects of demographics and clinical *** meta-analysis results were verified in an independent sample of 142 FEP patients and 142 age-and sex-matched healthy controls(HCs),using both a vertex-wise and a region of interest analysis,with multiple comparisons ***:The meta-analysis identified lower CTh in the rightmiddle temporal cortex(MTC)extending to superior temporal cortex(STC),insula,and anterior cingulate cortex(ACC)in FEP compared with *** significant correlations were identified between CTh alterations and demographic or clinical *** results were replicated in the independent dataset ***:This study identifies a robust pattern of cortical abnormalities in FEP and extends understanding of gray matter abnormalities and pathological mechanisms in FEP.

关键词： psychoradiology first episode psychosis early psychosis cortical thickness meta-analysis seed-based d mapping

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Longitudinal evolution of cortical thickness signature reflecting Lewy body dementia in isolated REM sleep behavior disorder:a prospective cohort study

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Translational Neurodegeneration 2023年第1期12卷 514-528页

作者： Jung Hwan Shin Heejung Kim Yu Kyeong Kim Eun Jin Yoon Hyunwoo Nam Beomseok Jeon Jee-Young Lee Department of Neurology Seoul Metropolitan Government-Seoul National University Boramae Medical Center and Seoul National University College of MedicineSeoulSouth Korea Department of Nuclear Medicine Seoul Metropolitan Government-Seoul National University Boramae Medical Center and Seoul National University College of MedicineSeoulSouth Korea Institute of Radiation Medicine Medical Research CenterSeoul National UniversitySeoulSouth Korea Department of Neurology Seoul National University Hospital and Seoul National University College of MedicineSeoulSouth Korea

Background The isolated rapid-eye-movement sleep behavior disorder(iRBD)is a prodromal condition of Lewy body disease including Parkinson’s disease and dementia with Lewy bodies(DLB).We aim to investigate the longitudinal evolution of DLB-related cortical thickness signature in a prospective iRBD cohort and evaluate the possible predictive value of the cortical signature index in predicting dementia-first phenoconversion in individuals with *** We enrolled 22 DLB patients,44 healthy controls,and 50 video polysomnography-proven iRBD *** underwent 3-T magnetic resonance imaging(MRI)and clinical/neuropsychological *** characterized DLB-related whole-brain cortical thickness spatial covariance pattern(DLB-pattern)using scaled subprofile model of principal components analysis that best differentiated DLB patients from age-matched *** analyzed clinical and neuropsychological correlates of the DLB-pattern expression scores and the mean values of the whole-brain cortical thickness in DLB and iRBD *** repeated MRI data during the follow-up in our prospective iRBD cohort,we investigated the longitudinal evolution of the cortical thickness signature toward Lewy body ***,we analyzed the potential predictive value of cortical thickness signature as a biomarker of phenoconversion in iRBD *** The DLB-pattern was characterized by thinning of the temporal,orbitofrontal,and insular cortices and relative preservation of the precentral and inferior parietal *** DLB-pattern expression scores correlated with attentional and frontal executive dysfunction(Trail Making Test-A and B:R=−0.55,P=0.024 and R=−0.56,P=0.036,respectively)as well as visuospatial impairment(Rey-figure copy test:R=−0.54,P=0.0047).The longitudinal trajectory of DLB-pattern revealed an increasing pattern above the cut-off in the dementia-first phenoconverters(Pearson’s correlation,R=0.74,P=6.8×10−4)but no significant change in parki

关键词： Rapid eye movement sleep behavior disorder Dementia with Lewy bodies Lewy body disease cortical thickness Spatial covariance pattern Magnetic resonance imaging

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The pattern of cortical thickness underlying disruptive behaviors in Alzheimer’s disease

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Psychoradiology 2022年第3期2卷 113-120页

作者： Raymond M.Xiong Teng Xie Haifeng Zhang Tao Li Gaolang Gong Xin Yu Yong He Experimental High School Attached to Beijing Normal University Beijing 100032China Dementia Care&Research Center Peking University Institute of Mental Health&National Clinical Research Center for Mental DisordersBeijing 100191China State Key Laboratory of Cognitive Neuroscience and Learning Beijing 100875China Beijing Key Laboratory of Brain Imaging and Connectomics Beijing Normal UniversityBeijing 100875China IDG/McGovern Institute for Brain Research Beijing Normal UniversityBeijing 100875China

Background Disruptive behaviors,including agitation,disinhibition,irritability,and aberrant motor behaviors,are commonly observed in patients with Alzheimer’s disease(AD).However,the neuroanatomical basis of these disruptive behaviors is not fully *** To confirm the differences in cortical thickness and surface area between AD patients and healthy controls and to further investigate the features of cortical thickness and surface area associated with disruptive behaviors in patients with *** One hundred seventy-four participants(125 AD patients and 49 healthy controls)were recruited frommemory clinics at the Peking University Institute of Sixth *** behaviors,including agitation/aggression,disinhibition,irritability/lability,and aberrant motor activity subdomain scores,were evaluated using the Neuropsychiatry *** whole-brain vertex-based and region-of-interest-based cortical thickness and surface area analyses were automatically conducted with the CIVET pipeline based on structural magnetic resonance *** group-based statistical comparisons and brain-behavior association analyses were performed using general linear models,with age,sex,and education level as *** Compared with healthy controls,the AD patients exhibited widespread reduced cortical thickness,with the most significant thinning located in the medial and lateral temporal and parietal cortex,and smaller surface areas in the left fusiform and left inferior temporal *** total scores of disruptive behaviors were significantly associated with cortical thinning in several regions that are involved in sensorimotor processing,language,and expression *** total score of disruptive behaviors did not show significant associations with surface *** highlight that disruptive behaviors in patientswith AD are selectively associated with cortical thickness abnormalities in sensory,motor,and language regions,which provides

关键词： Disruptive behaviors Alzheimer’s disease cortical thickness surface area magnetic resonance imaging(MRI) CIVET algorithm

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Abnormal Alterations of cortical thickness in 16 Patients with Type 2 Diabetes Mellitus： A Pilot MRI Study

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Chinese Medical Sciences Journal 2017年第2期32卷 75-82页

作者： ZhiyeChen XiujuanZang MengqiLiu MengyuLiu JinfengLi ZhaoyanGu LinMa Department of Radiology Chinese PLA General Hospital Beijing 100853 China Department of Radiology 4Department of Endocrinology Hainan Branch of Chinese PLA General Hospital Sanya Hainan 572013 China Department of Radiology The Fifth People's Hospital Shizuishan Ningxia 753000 China

Objective The aim of this study is to investigate the cerebral cortical thickness changes in type 2 diabetes mellitus （T2DM） using a whole brain cortical thickness mapping system based on brain magnetic resonance imaging （MRI）. Methods High resolution three-dimensional T1-weighted fast spoiled gradient recalled echo MR images were obtained from 16 patients with T2DM, as well as from 16 normal controls. The whole brain cortical thickness maps were generated, and the cortical thickness of each brain region was calculated according to gyral based regions of interest （ROI） using an automated labeling system by the Freesurfer software. We compared mean cortical thickness at each brain region by the analysis of covariance with age and sex as covariates. The regional difference of the cortical thickness over the whole brain was compared by the analysis of surface-based cortical thickness. Results Mean cortical thicknesses analysis showed bilateral cerebrum in the patients with T2DM （left： 2.52±0.07 mm; right： 2.51±0.08 mm） were significant thinner than those in the normal controls （left： 2.56±0.09 mm; right： 2.56±0.09 mm）（both P〈0.05）. Regional cortical thinning in T2DM was demonstrated in the paracentral lobule, postcentral gyrus, lateral occipital gyrus, lingual gyrus, precuneus, superior temporal gyrus, middle temporal gyrus, inferior temporal gyrus and posterior cingulate gyrus, compared to the normal controls. The cortical thickness of left middle cingulate and right inferior temporal gyrus were negatively correlated with the disease course. Conclusion A widespread cortical thinning was revealed in patients with T2DM by the analysis of brain cortical thickness on MR. Our finding supports the idea that T2DM could lead to subtle diabetic brain structural changes.

关键词： type 2 diabetes mellitus brain cerebral cortex cortical thickness magnetic resonance imaging

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Cross-sectional associations between cortical thiclmess and physical activity in older adults with spontaneous memory complaints:The MAPT Study

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Journal of Sport and Health Science 2023年第3期12卷 324-332页

作者： Jérémy Raffin Yves Rolland Clara Fischer Jean-Francois Mangin Audrey Gabelle Bruno Vellas Philipe de Souto Barreto the MAPT/DSA Group Gérontopôle de Toulouse Institut du VieillissementCentre Hospitalo-Universitaire de ToulouseToulouse 31000France UniversitéPaul-Sabatier/Institut National de la Santéet de la Recherche Médicale UnitéMixte de Recherche 1027 Facultéde médecineUniversity of Toulouse ⅢToulouse 31000France Centre pour l'Acquisition et le Traitement des Images Multicenter Neuroimaging Platform NeurospinUniversitéParis-SaclayGif sur Yvette 91191France Memory Resources and Research Center Montpellier University HospitalMontpellier 34295France Institut National de la Santéet de la Recherche Médicale Unité1061 i-site Montpellier Universitéd'Excellence University of MontpellierMontpellier 34090France 不详

Background:Age-related changes in brain structure may constitute the starting point for cerebral function *** activity(PA)demonstrated favorable associations with total brain volume,but its relationship with cortical thickness(CT)remains *** investigated the cross-sectional associations between PA level and CT in community-dwelling people aged 70 years and ***:A total of 403 older adults aged 74.8±4.0 years(mean±SD)who underwent a baseline magnetic resonance imaging examination and who had data on PA and confounders were *** was assessed with a *** were categorized according to PA *** linear regressions were used to compare the brain CT(mm)of the inactive group(no PA at all)with 6 active groups(growing PA levels)in 34 regions of ***:Compared with inactive persons,people who achieved PA at a level of 1500-1999 metabolic equivalent task-min/week(i.e.,about6-7 h of brisk walking for exercise) and those who achieved it at 2000-2999 metabolic equivalent task-min/week(i.e.,8-11 h of brisk walking for exercise)had higher CT in the fusiform gyrus and the temporal ***,dose-response associations between PA and CT were found in the fusiform gyrus(B=0.011,SE=0.004,adj.p=0.035),the temporal pole(B=0.026,SE=0.009,adj.p=0.048),and the caudal middle frontal gyrus,the entorhinal,medial orbitofrontal,lateral occipital,and insular ***:This study demonstrates a positive association between PA level and CT in temporal areas such as the fusiform gyrus,a brain region often associated to Alzheimer’s disease in people aged 70 years and *** investigations focusing on PA type may help to fulfil remaining knowledge gaps in this field.

关键词： Alzheimer's disease Brain aging cortical thickness Physical activity

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Surface-based map plasticity of brain regions related to sensory motor and pain information processing after osteonecrosis of the femoral head

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Neural Regeneration Research 2022年第4期17卷 806-811页

作者： Jie Ma Xu-Yun Hua Mou-Xiong Zheng Jia-Jia Wu Bei-Bei Huo Xiang-Xin Xing Sheng-Yi Feng Bo Li Jian-Guang Xu School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Traumatology and Orthopedics Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center) Tongji UniversityShanghaiChina Center of Rehabilitation Medicine Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina

Pain is one of the manifestations of hip disorder and has been proven to lead to the remodeling of somatotopic map plasticity in the ***,most studies are volume-based which may lead to inaccurate anatomical positioning of functional *** methods that work on the cortical surface may be more sensitive than those using the full brain volume and thus be more suitable for map plasticity *** this prospective cross-sectional study performed in Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,China,20 patients with osteonecrosis of the femoral head(12 males and 8 females,aged 56.80±13.60 years)and 20 healthy controls(9 males and 11 females,aged 54.56±10.23 years)were included in this *** of resting-state functional magnetic resonance imaging were *** results revealed that compared with healthy controls,compared with the healthy controls,patients with osteonecrosis of the femoral head(ONFH)showed significantly increased surface-based regional homogeneity(Re Ho)in areas distributed mainly in the left dorsolateral prefrontal cortex,frontal eye field,right frontal eye field,and the premotor cortex and decreased surface-based Re Ho in the right primary motor cortex and primary sensory *** showing significant differences in surfacebased Re Ho values between the healthy controls and patients with ONFH were defined as the regions of ***-based functional connectivity was performed to investigate interregional functional *** the areas with decreased surface-based Re Ho in the frontal eye field and right premotor cortex were used as the regions of interest,compared with the healthy controls,the patients with ONFH displayed increased functional connectivity in the right middle frontal cortex and right inferior parietal cortex and decreased functional connectivity in the right precentral cortex and right middle occipital ***

关键词： cortical thickness functional connectivity hip disorder osteonecrosis of the femoral head Re Ho sensorimotor cortex surface-based map plasticity volume of subcortical gray matter nuclei

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A Systematic Characterization of Structural Brain Changes in Schizophrenia

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Neuroscience Bulletin 2020年第10期36卷 1107-1122页

作者： Wasana Ediri Arachchi Yanmin Peng Xi Zhang Wen Qin Chuanjun Zhuo Chunshui Yu Meng Liang School of Medical Imaging and Tianjin Key Laboratory of Functional Imaging Tianjin Medical UniversityTianjin 300203China Department of Radiography and Radiotherapy Faculty of Allied Health SciencesGeneral Sir John Kotelawala Defence UniversityRatmalana 10390Sri Lanka Department of Radiology and Tianjin Key Laboratory of Functional Imaging Tianjin Medical University General HospitalTianjin 300052China Department of Psychiatric-Neuroimaging-Genetics and Comorbidity Laboratory Tianjin Mental Health CenterTianjin Anding HospitalTianjin 300222China CAS Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai 200031China

A systematic characterization of the similarities and differences among different methods for detecting structural brain abnormalities in schizophrenia,such as voxel-based morphometry(VBM),tensor-based morphometry(TBM),and projection-based thickness(PBT),is important for understanding the brain pathology in schizophrenia and for developing effective biomarkers for a diagnosis of ***,such studies are still ***,we performed VBM,TBM,and PBT analyses on T1-weighted brain MR images acquired from 116 patients with schizophrenia and 116 healthy *** found that,although all methods detected wide-spread structural changes,different methods captured different information-only 10.35%of the grey matter changes in cortex were detected by all three methods,and VBM only detected 11.36%of the white matter changes detected by ***,pattern classification between patients and controls revealed that combining different measures improved the classification accuracy(81.9%),indicating that fusion of different structural measures serves as a better neuroimaging marker for the objective diagnosis of schizophrenia.

关键词： Voxel-based morphometry Tensor-based morphometry Deformation-based morphometry cortical thickness Multivariate pattern analysis Structural MRI Schizophrenia

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Morphometric changes in the cortex following acute mild traumatic brain injury

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Neural Regeneration Research 2022年第3期17卷 587-593页

作者： Meng-Jun Li Si-Hong Huang Chu-Xin Huang Jun Liu Department of Radiology the Second Xiangya Hospital of Central South UniversityChangshaHunan ProvinceChina

Morphometric changes in cortical thickness(CT),cortical surface area(CSA),and cortical volume(CV) can reflect pathological changes after acute mild traumatic brain injury(m TBI).Most previous studies focused on changes in CT,CSA,and CV in subacute or chronic m TBI,and few studies have examined changes in CT,CSA,and CV in acute m ***,acute m TBI patients typically show transient cognitive impairment,and few studies have reported on the relationship between cerebral morphological changes and cognitive function in patients with m *** prospective cohort study included 30 patients with acute m TBI(15 males,15 females,mean age 33.7 years) and 27 matched healthy controls(12 males,15 females,mean age 37.7 years) who were recruited from the Second Xiangya Hospital of Central South University between September and December ***-resolution T1-weighted images were acquired within 7 days after the onset of m *** results of analyses using Free Surfer software revealed significantly increased CSA and CV in the right lateral occipital gyrus of acutestage m TBI patients compared with healthy controls,but no significant changes in *** acute-stage m TBI patients also showed reduced executive function and processing speed indicated by a lower score in the Digital Symbol Substitution Test,and reduced cognitive ability indicated by a longer time to complete the Trail Making *** increased CSA and CV in the right lateral occipital gyrus were negatively correlated with performance in the Trail Making Test part *** findings suggest that cognitive deficits and cortical alterations in CSA and CV can be detected in the acute stage of m TBI,and that increased CSA and CV in the right lateral occipital gyrus may be a compensatory mechanism for cognitive dysfunction in acute-stage m TBI *** study was approved by the Ethics Committee of the Second Xiangya Hospital of Central South University,China(approval No.086) on February 9,2019.

关键词： acute mild brain trauma injury Alzheimer's disease cognitive function cortical surface area cortical thickness cortical volume Free Surfer surface-based morphometry

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Structural remodeling in related brain regions in patients with facial synkinesis

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Neural Regeneration Research 2021年第12期16卷 2528-2533页

作者： Jia-Jia Wu Ye-Chen Lu Mou-Xiong Zheng Xu-Yun Hua Chun-Lei Shan Wei Ding Jian-Guang Xu Center of Rehabilitation Medicine Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Wound Healing Center Ruijin HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Trauma and Orthopedics Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghaiChina

Facial synkinesis is a troublesome sequelae of facial nerve *** is difficult to recover from synkinesis,despite improved surgical techniques for isolating the peripheral facial nerve ***,it remains unclear whether long-term dysfunction of motor control can lead to irreversible plasticity-induced structural brain *** case-control study thus investigated the structural brain alterations associated with facial *** study was conducted at Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,*** patients with facial synkinesis(2 male and 18 female,aged 33.35±6.97 years)and 19 healthy volunteers(2 male and 17 female,aged 33.21±6.75 years)underwent magnetic resonance imaging,and voxel-based and surface-based morphometry techniques were used to analyze *** was no significant difference in brain volume between patients with facial synkinesis and healthy *** with facial synkinesis exhibited a significantly reduced cortical thickness in the contralateral superior and inferior temporal gyri and a reduced sulcal depth of the ipsilateral precuneus compared with healthy *** addition,sulcal depth of the ipsilateral precuneus was negatively correlated with the severity of *** findings suggest that there is a structural remodeling of gray matter in patients with facial synkinesis after facial nerve *** study was approved by the Ethics Review Committee of the Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,China(approval No.2017-365-T267)on September 13,2017,and was registered with the Chinese Clinical Trial Registry(registration number:ChiCTR1800014630)on January 25,2018.

关键词： brain plasticity cortical thickness depression facial nerve paralysis facial synkinesis peripheral nerve injury sulcal depth structural remodeling surface-based morphometry voxel-based morphometry

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cortical and Subcortical Grey Matter Abnormalities in White Matter Hyperintensities and Subsequent Cognitive Impairment

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Neuroscience Bulletin 2021年第6期37卷 789-803页

作者： Wenhao Zhu Hao Huang Shiqi Yang Xiang Luo Wenzhen Zhu Shabei Xu Qi Meng Chengchao Zuo Yong Liu Wei Wang Alzheimer’s Disease Neuroimaging Initiative Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Radiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Brainnetome Center and National Laboratory of Pattern Recognition Institute of AutomationChinese Academy of SciencesBeijing 100190China School of Artificial Intelligence Beijing University of Posts and TelecommunicationsBeijing 100876China University of the Chinese Academy of Sciences Beijing 100049China 不详

Grey matter(GM)alterations may contribute to cognitive decline in individuals with white matter hyperintensities(WMH)but no consensus has yet ***,we investigated cortical thickness and grey matter volume in 23 WMH patients with mild cognitive impairment(WMH-MCI),43 WMH patients without cognitive impairment,and 55 healthy *** WMH groups showed GM atrophy in the bilateral thalamus,fronto-insular cortices,and several parietal-temporal regions,and the WMH-MCI group showed more extensive and severe GM *** GM atrophy in the thalamus and fronto-insular cortices was associated with cognitive decline in the WMH-MCI patients and may mediate the relationship between WMH and cognition in WMH ***,the main results were well replicated in an independent dataset from the Alzheimer's Disease Neuroimaging Initiative database and in other control *** comprehensive results provide robust evidence of specific GM alterations underlying WMH and subsequent cognitive impairment.

关键词： White matter hyperintensities Cognitive impairment cortical thickness Grey matter volume Replication

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