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Exploring the therapeutic effects of cortex lycii on essential hypertension

TMR Pharmacology Research 2023年第4期3卷 20-34页

作者： Xing-Yuan Chen Ju-Min Xie Hubei Key Laboratory of Renal Disease Occurrence and Intervention Hubei Polytechnic UniversityHuangshi 435003China

Background:Essential hypertension affects over a billion people *** the absence of a definitive cure,current treatments primarily aim to manage blood pressure *** is a compelling need for antihypertensive medications that offer high effectiveness,low toxicity,and minimal side ***:This study seeks to investigate the antihypertensive properties of cortex lycii by employing network pharmacology and validating the findings through molecular ***:We utilized various platforms and databases related to traditional Chinese medicine to identify the active compounds within cortex *** associated with hypertension were gathered from well-established disease-related *** targets were delineated using the ***,we conducted GO and KEGG analyses through the DAVID platform and visualized the resultant network with *** docking was carried out using Autodock Vina and ***:Our investigation revealed ten active compounds in cortex lycii that demonstrated correlation with 82 essential hypertension-associated *** shared targets were categorized into four distinct clusters,each with unique *** hub targets were singled out based on predefined selection *** analysis unveiled the participation of shared targets in various biological processes linked to *** analysis identified ten significant signaling pathways associated with hypertension *** docking analysis provided confirmation of the interaction between the selected hub targets and the active ***:cortex lycii,a traditional Chinese herb with a long history of use,exerts its antihypertensive effects through a combination of active compounds,involvement of multiple targets,regulation of various biological processes,and modulation of key signaling pathways.

关键词： cortex lycii essential hypertension molecular docking network pharmacology

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