Exploring the therapeutic effects of Cortex Lycii on essential hypertension

作     者：Xing-Yuan Chen Ju-Min Xie 

作者机构：Hubei Key Laboratory of Renal Disease Occurrence and InterventionHubei Polytechnic UniversityHuangshi 435003China 

出 版 物：《TMR Pharmacology Research》 (TMR药理学研究)

年 卷 期：2023年第3卷第4期

页      面：20-34页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by Local special projects in major health of Hubei Provincial Science and Technology Department(2022BCE054) Key scientific research projects of Hubei polytechnic University(23xjz08A) 

主　　题：Cortex Lycii essential hypertension molecular docking network pharmacology 

摘      要：Background:Essential hypertension affects over a billion people *** the absence of a definitive cure,current treatments primarily aim to manage blood pressure *** is a compelling need for antihypertensive medications that offer high effectiveness,low toxicity,and minimal side ***:This study seeks to investigate the antihypertensive properties of Cortex Lycii by employing network pharmacology and validating the findings through molecular ***:We utilized various platforms and databases related to traditional Chinese medicine to identify the active compounds within Cortex *** associated with hypertension were gathered from well-established disease-related *** targets were delineated using the ***,we conducted GO and KEGG analyses through the DAVID platform and visualized the resultant network with *** docking was carried out using Autodock Vina and ***:Our investigation revealed ten active compounds in Cortex Lycii that demonstrated correlation with 82 essential hypertension-associated *** shared targets were categorized into four distinct clusters,each with unique *** hub targets were singled out based on predefined selection *** analysis unveiled the participation of shared targets in various biological processes linked to *** analysis identified ten significant signaling pathways associated with hypertension *** docking analysis provided confirmation of the interaction between the selected hub targets and the active ***:Cortex Lycii,a traditional Chinese herb with a long history of use,exerts its antihypertensive effects through a combination of active compounds,involvement of multiple targets,regulation of various biological processes,and modulation of key signaling pathways.