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Impact of non-alcoholic fatty liver disease on coronavirus disease 2019: A systematic review

World Journal of Hepatology 2024年第8期16卷 1185-1198页

作者： Abdul Moeed Muhammad Omar Larik Muhammad Ahmed Ali Fahim Hafsah Alim Ur Rahman Lubna Najmi Mah I Kan Changez Muhammad Moiz Javed Md Al Hasibuzzaman Department of Internal Medicine Dow University of Health SciencesKarachi 74200SindhPakistan Department of Internal Medicine Dow International Medical CollegeKarachi 74200SindhPakistan Department of Internal Medicine Ziauddin UniversityKarachi 75000SindhPakistan Department of Research Yale UniversityNew Haven 06520CTUnited States Department of Internal Medicine King Edward Medical UniversityLahore 54000PunjabPakistan Institute of Nutrition and Food Science University of DhakaDhaka 1000Bangladesh Department of Medicine The Affiliated Hospital of Medical School of Ningbo UniversityNingbo 315211Zhejiang ProvinceChina

BACKGROUND Many studies have revealed a link between non-alcoholic fatty liver disease(NA-FLD)and coronavirus disease 2019(COVID-19),making understanding the relationship between these two conditions an absolute *** To provide a qualitative synthesis on the currently present data evaluating COVID-19 and *** This systematic review was conducted in accordance with the guidelines pro-vided by preferred reporting items for systematic reviews and meta-analyses and the questionnaire utilized the population,intervention,comparison,and outcome *** search strategy was run on three separate databases,PubMed/MEDLINE,Scopus,and Cochrane Central,which were systematically searched from inception until March 2024 to select all relevant *** addition,***,***,and Google Scholar were searched to identify grey *** After retrieval of 11 studies,a total of 39282 patients data were *** was found in 11.5%and 9.4%of people in NAFLD and non-NAFLD *** all,23.2%of NAFLD patients and 22%of non-NAFLD admissions diagnosed with COVID-19 were admitted to the intensive care unit,with days of stay *** support ranged from 5%to 40.5%in the NAFLD cohort and from 3.1%to 20%in the non-NAFLD *** incidence of acute liver injury showed *** improvement on days 7 and 14 between the two classifications was *** stay ranged from 9.6 days to 18.8 days and 7.3 days to 16.4 days in the aforementioned cohorts respectively,with 73.3%and 76.3%of patients being *** rates *** Clinical outcomes except mortality consistently showed a worsening trend in patients with NAFLD and concomitant *** research in conducting prospective longitudinal studies is essential for a more powerful conclusion.

关键词： Non-alcoholic fatty liver disease coronavirus disease 2019 Mechanical ventilation Intensive care unit Acute liver injury

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Molecular Insight into the Therapeutic Promise of Xuebijing Injection against coronavirus disease 2019

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World Journal of Traditional Chinese Medicine 2020年第2期6卷 203-215页

作者： Dan Zhang Jin-Tao Lv Bing Zhang Ri-Na Sa Bing-Bing Ma Xiao-Meng Zhang Zhi-Jian Lin Department of Clinical Chinese Pharmacy School of Chinese Materia MedicaBeijing University of Chinese MedicineBeijing 100029China Center for Pharmacovigilance and Rational Use of Chinese Medicine Beijing University of Chinese MedicineBeijing Department of Pharmacy Gansu Provincial HospitalLanzhouChina

Background:The potential human-to-human transmission of the coronavirus pneumonia(coronavirus disease 2019[COVID-19])has caused an outbreak of acute respiratory *** injection is recommended as first-line treatment for the severe and critical patients with *** aim of present study is to interpret the pharmacological mechanisms and molecular connections of Xuebijing injection against COVID-19 by utilizing the approaches of network pharmacology and molecular *** and Methods:Active ingredients of Xuebijing injection were collected by Traditional Chinese Medicine Systems Pharmacology(TCMSP)database,and putative therapeutic targets were screened from TCMSP,Swiss Target Prediction,and STITCH ***,the protein–protein interactions,topological analysis,and pathway enrichment were established to distinguish the hub targets and pathways by employing STRING database,Cytoscape software,DAVID database,*** addition,the potential interaction and binding activity of candidate ingredients in Xuebijing injection with core targets were revealed by molecular docking simulation(Auto Dock software).Results:A total of 115 bioactive components in Xuebijing injection were collected,and416 targets including AKT1,TP53,VEGFA,ALB,TNF and so on were responsible for treating *** analysis revealed that matching core targets were closely associated with the inhibition of cytokine storm for its clinical beneficial effects in severe *** results of enrichment analysis indicated that PI3 K-Akt signaling pathway,human T-cell leukemia virus type 1 infection,mitogen-activated protein kinase signaling pathway,tuberculosis,focal adhesion,TNF signaling pathway,and small-cell lung cancer were represented pathways of Xuebijing injection against COVID-19 in terms of lung inflammation,virus infection,and lung ***,the active ingredients of Xuebijing injection exerted superior binding activities with 3 CLpro and ang

关键词： coronavirus disease 2019 molecular docking network pharmacology therapeutic mechanism Xuebijing injection

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Comprehensive Comparison and Analysis of the Prevention and Treatment of coronavirus disease 2019 and Severe Acute Respiratory Syndrome with Traditional Chinese Medicine

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World Journal of Traditional Chinese Medicine 2020年第2期6卷 124-131页

作者： Ying Chen Jing-Jing Zhang Yan Liu Hong-Cai Shang Key Laboratory of Chinese Internal Medicine of Ministry of Education Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China First Clinical Medical College Beijing University of Chinese MedicineBeijingChina

Since December 2019 the coronavirus disease 2019(COVID-19)has erupted in many places around the world,which is strong infectious and highly *** the outbreak of COVID-19 in China,traditional Chinese medicine(TCM)has been in the front line of the fight against the *** has shown characteristics and advantages in the prevention and treatment of *** also played an important role in the winter of 2002 and in the spring of 2003 during the outbreak of severe acute respiratory syndrome(SARS).This article compares the strategies,programs,measures,resource investments,and effects of TCM for the prevention and treatment of COVID-19 with those for *** present,the involvement of TCM has been earlier,faster,and more comprehensive in the fight against the epidemic and has shown good clinical efficacy and treatment prospects.

关键词： coronavirus disease 2019 prevention and treatment of traditional Chinese medicine severe acute respiratory syndrome

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Current Global Status and Future Development of Traditional Chinese Medicine in the Prevention and Treatment of coronavirus disease 2019

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World Journal of Traditional Chinese Medicine 2021年第2期7卷 155-166页

作者： Ze-Jia Song Wan Najbah Nik Nabil Zhi-Chao Xi Hong-Xi Xu School of Pharmacy Shanghai University of Traditional Chinese MedicineShanghaiChina Pharmaceutical Services Program Ministry of HealthPetaling JayaMalaysia Shuguang Hospital Shanghai University of Traditional Chinese MedicineShanghaiChina

Recognizing the potential of globalizing traditional Chinese medicine(TCM)for coronavirus disease 2019(COVID-19),this review summarizes the current global use of TCM for COVID-19,status of the internationalization of TCM,and strategy on globalizing TCM for ***-19 is a novel coronavirus disease that has sparked a pandemic in March 2020 affecting over 110 *** researchers have been racing to develop targeted anti-COVID-19 treatment and vaccine,they are still currently ***,in treating patients infected with COVID-19,western medicine mainly recommended symptomatic treatment and *** drugs are used in the context of clinical trials,and the FDA still not yet approved these drugs for *** the other hand,TCM proposed herbal treatment for suspected individuals to take within their observation period,as well as for confirmed COVID-19 patients to take during active phase of disease and during *** China,Integrative Chinese-Western Medicine had been used in treating 91.5%of COVID-19 patients and showed its strength in reducing disease severity,shortening recovery time,and lowering the mortality *** obstacles in globalizing TCM for the treatment of COVID-19,promoting appropriate use of locally registered TCM products may prevent disease in susceptible individuals,improve the quality of life,and assist in the recovery of COVID-19 *** increasing global acceptance,TCM may play a more important role in the battle against infectious disease in the future.

关键词： coronavirus disease 2019 coronavirus pneumonia traditional Chinese medicine traditional Chinese medicine globalization

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Traditional Chinese medicine for treatment of coronavirus disease 2019:a review

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Traditional Medicine Research 2020年第2期5卷 65-73页

作者： Huan-Tian Cui Yu-Ting Li Li-Ying Guo Xiang-Guo Liu Lu-Shan Wang Jian-Wei Jia Jia-Bao Liao Jing Miao Zhai-Yi Zhang Li Wang Hong-Wu Wang Wei-Bo Wen Shandong Provincial Key Laboratory of Animal Cell and Developmental Biology School of Life SciencesShandong UniversityQingdao 250100China College of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Integrated Traditional and Western Medicine Tianjin Second People’s HospitalTianjin 300192China State Key Laboratory of Microbial Technology Microbial Technology InstituteShandong UniversityQingdao 266237China Department of Emergency Jiaxing Hospital of Traditional Chinese MedicineJiaxing 314001China College of Integrated Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of pharmacy Tianjin Second People’s HospitalTianjin 300192China Department of Endocrinology in Yunnan Provincial Hospital of Traditional Chinese Medicine Kunming 650021China

prevalence.A number of clinical workers and researchers have made great efforts to understand the pathogenesis and clinical characteristics and develop effective drugs for ***,no effective drugs with antiviral effects on severe acute respiratory syndrome coronavirus 2 have been discovered *** Chinese medicine(TCM)has gained abundant experience in the treatment of infectious diseases for thousands of *** this review,the authors summarized the clinical outcome,pathogensis and current application of TCM on coronavirus disease ***,we discussed the potential mechanisms and the future research directions of TCM against severe acute respiratory syndrome coronavirus 2.

关键词： Severe acute respiratory syndrome coronavirus 2 coronavirus disease 2019 Clinical outcome Angiotensin-converting enzyme 2 Traditional Chinese medicine

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Prevalence and predictors of smartphone addiction and insomnia among nurses working in the outpatient department after the second wave of the coronavirus disease 2019 pandemic

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Journal of Integrative Nursing 2023年第4期5卷 273-279页

作者： Manisha MEHRA Poonam JOSHI Surya Kant TIWARI Praveen AGGRAWAL Kamlesh CHANDELIA Srinithya RAGHAVAN Department of Nursing Services All India Institute of Medical SciencesNew DelhiIndia College of Nursing All India Institute of Medical SciencesKalyaniWest BengalIndia College of Nursing All India Institute of Medical SciencesRaebareliUttar PradeshIndia Department of Emergency Medicine All India Institute of Medical SciencesNew DelhiIndia Department of In-Service Education All India Institute of Medical SciencesNew DelhiIndia

Objectives:The present study aims to assess the prevalence and predictors of smartphone addiction and insomnia among nurses working in the outpatient department(OPD)after the second wave of the coronavirus disease 2019(COVID-19)*** and Methods:A descriptive,cross-sectional study was carried out among 117 OPD nurses between October and December 2021 using a purposive sampling *** self-reported standardized scales,the Smartphone Addiction Scale-ShortVersion and Insomnia Severity Index were ***–Smirnov test,Mann–Whitney U,and Kruskal–Wallis Htest were ***’s correlation and Scatter plot were used to determine the relationship between the study variables.A stepwise multiple linear regression analysis was also ***:The majority of participants had slight smartphone addiction(78.6%)and suffered from sub-threshold to severe forms of insomnia(73.5%).A significant mild positive correlation was found between smartphone addiction and insomnia(r=0.195,P<0.05).Stepwise multivariate logistic regression analysis predicted factors such as female gender and exposure to smartphones for more than 5 years influencing smartphone addiction.A strong influence of exposure to the smartphone for more than 5 years was found on insomnia ***:Smartphone addiction and insomnia were identified problems among nurses working in the OPD after the second wave of the COVID-19 pandemic,requiring an urgent need to identify and manage various factors responsible for smartphone addiction and insomnia such as female gender and years of exposure to smartphones.

关键词： coronavirus disease 2019 insomnia nurses sleeping disturbances smartphone addiction

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Analysis of Interventional Clinical Research Protocols Related to coronavirus disease 2019 and Future Expectations

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World Journal of Traditional Chinese Medicine 2020年第2期6卷 139-144页

作者： Ya-Feng Wang Min Du Rui Su Clinical Evidence-Based Research Guidance Center World Federation of Chinese Medicine SocietiesBejjing 100101China Scientific Research Depar tment Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijingChina

coronavirus disease 2019(COVID-19)is a newly emerging infectious *** its outbreak,researchers started a large number of clinical interventional studies,using a variety of interventions to study the different types of COVID-19 *** this article,we searched the websites of Chinese Clinical Trial Registry,Clinical ***,etc.,to study the publicly registered research *** the classification and summary of interventional methods,evaluation indicators,research design,etc.,this article provided readers with the outline of clinical research about COVID-19,and looked forward to the scientificity,feasibility,and future evidence of the clinical researches.

关键词： Clinical trial protocol coronavirus disease 2019 interventional study

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Public health preparedness and responses to the coronavirus disease 2019(COVID-19)pandemic in South Asia:a situation and policy analysis

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Global Health Journal 2020年第4期4卷 121-132页

作者： Amitabha Sarkar Guangqi Liu Yinzi Jin Zheng Xie Zhi-Jie Zheng Centre of Social Medicine and Community Health School of Social Sciences(Building-II)Jawaharlal Nehru UniversityNew Mehrauli RoadNew Delhi 110067India Department of Global Health School of Public HealthPeking University38 Xueyuan RoadHaidian DistrictBeijing 100191China Institute for Global Health Peking University38 Xueyuan RoadHaidian DistrictBeijing 100191China

Like rest of the world,the South Asian region is facing enormous challenges with the coronavirus disease 2019(COVID-19)*** socio-economic context of the eight South Asian countries is averse to any longterm lockdown program,but the region still observed stringent lockdown close to two *** paper analyzed major measures in public health preparedness and responses in those countries in the *** research was based on a situation analysis to discuss appropriate plan for epidemic preparedness,strategies for prevention and control measures,and adequate response management *** on the data from March 21 to June 26,2020,it appeared lockdown program along with other control measures were not as effective to arrest the exponential growth of fortnightly COVID-19 cases in Afghanistan,Bangladesh,India,Nepal and ***,Bhutan,Maldives and Sri Lanka have been successfully limiting the spread of the *** in-depth analysis of prevention and control measures espoused densely populated context of South Asia needs community-led intervention strategy,such as case containment,in order to reverse the growing trend,and adopt the policy of mitigation instead of suppression to formulate COVID-19 action *** the other hand,mechanism for response management encompassed a four-tier approach of governance to weave community-led local bodies with state,national and international governance actors for enhancing the countries’emergency operation *** is concluded resource-crunch countries in South Asia are unable to cope with the disproportionate demand of capital and skilled health care workforce at the time of the ***,response management needs an approach of governance maximization instead of resource *** epidemiologic management of population coupled with suitable public health prevention and control measures may be a more appropriate strategy to strike a balance between economy and population health during the t

关键词： coronavirus disease 2019 COVID-19 Pandemic Intervention strategy Epidemiological management Public health South Asia

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A short review of male genito-urinary lesions caused by coronavirus disease 2019(COVID-19)

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Current Urology 2022年第2期16卷 63-64页

作者： Xun Sun Jiaju Lyu Department of Urology Shandong Provincial HospitalShandong UniversityJinan250021China Department of Urology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinanChina

coronavirus disease 2019(COVID-19)is a novel infectious disease that has spread worldwide since it first appeared in December *** can cause pathologies in several organs of the body through direct and indirect *** more than two years of study,the effects of COVID-19 on the genitourinary system are now well-evidenced as COVID-19 has considerable effects on the kidneys,testes,vas deferens,epididymis,seminal vesicles,prostate,and *** invasion is mainly characterized by acute kidney *** invasion is characterized by orchitis,testicular epididymitis,*** COVID-19 has been suspected to spread via serum,evidence for the presence of the virus in the semen of patients is currently ***-19 also impacts the sexual function of patients to varying degrees,with some patients developing erectile *** underlying mechanisms of COVID-19 invasion into the genitourinary system have not been clearly identified,and more clinical studies are *** review discusses the impact of COVID-19 on the genitourinary system and male health.

关键词： Acute kidney injury coronavirus disease 2019 Erectile dysfunction Genitourinary system Semen

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Wunderlich syndrome,an unexpected urological complication in a patient with coronavirus disease 2019(COVID-19):A case report

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Current Urology 2022年第2期16卷 74-76页

作者： Fabrizio Presicce Marco Martini Francesco Minisola Cristina Falavolti Alessio Filianoti Department of Urology San Filippo Neri HospitalRome00135Italy

We describe the first case of Wunderlich syndrome as a hemorrhagic complication in a patient with severe acute respiratory syndrome coronavirus 2 infection and acute respiratory distress *** possible underlying pathophysiological mechanisms have been extensively *** management included selective angioembolization of the upper polar arterial branches of the left kidney and discontinuation of *** patient was discharged after 18 *** other localizations or local recurrence of bleeding occurred during the *** report suggests a broad spectrum of clinical manifestations in patients with coronavirus disease *** observed in our clinical case,in addition to thrombotic complications,bleeding is a significant cause of morbidity in coronavirus disease 2019 *** studies should determine whether these urological bleeding sequelae are a direct manifestation of the infection or an indirect effect of thromboprophylaxis.

关键词： Bleeding Coagulopathy coronavirus disease 2019 Interventional radiology Wunderlich syndrome

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