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Molecular Insight into the Therapeutic Promise of Xuebijing Injection against Coronavirus Disease 2019

Molecular Insight into the Therapeutic Promise of Xuebijing Injection against Coronavirus Disease 2019

作     者:Dan Zhang Jin-Tao Lv Bing Zhang Ri-Na Sa Bing-Bing Ma Xiao-Meng Zhang Zhi-Jian Lin Dan Zhang;Jin-Tao Lv;Bing Zhang;Ri-Na Sa;Bing-Bing Ma;Xiao-Meng Zhang;Zhi-Jian Lin

作者机构:Department of Clinical Chinese PharmacySchool of Chinese Materia MedicaBeijing University of Chinese MedicineBeijing 100029China Center for Pharmacovigilance and Rational Use of Chinese MedicineBeijing University of Chinese MedicineBeijing Department of PharmacyGansu Provincial HospitalLanzhouChina 

出 版 物:《World Journal of Traditional Chinese Medicine》 (世界中医药杂志(英文))

年 卷 期:2020年第6卷第2期

页      面:203-215页

学科分类:100506[医学-中医内科学] 1006[医学-中西医结合] 1005[医学-中医学] 100602[医学-中西医结合临床] 10[医学] 

基  金:supported by the National Natural Science Foundation of China to BZ(Grant No.81874349) the Programs Foundation for Leading Talents in State Administration of TCM of China-“Qihuang scholars”Project(10400633210004) the National Special Support Plan for High-level Talents(Plan of ten thousand people),Famous Teacher Program to Professor Bing Zhang 

主  题:Coronavirus disease 2019 molecular docking network pharmacology therapeutic mechanism Xuebijing injection 

摘      要:Background:The potential human-to-human transmission of the coronavirus pneumonia(coronavirus disease 2019[COVID-19])has caused an outbreak of acute respiratory *** injection is recommended as first-line treatment for the severe and critical patients with *** aim of present study is to interpret the pharmacological mechanisms and molecular connections of Xuebijing injection against COVID-19 by utilizing the approaches of network pharmacology and molecular *** and Methods:Active ingredients of Xuebijing injection were collected by Traditional Chinese Medicine Systems Pharmacology(TCMSP)database,and putative therapeutic targets were screened from TCMSP,Swiss Target Prediction,and STITCH ***,the protein–protein interactions,topological analysis,and pathway enrichment were established to distinguish the hub targets and pathways by employing STRING database,Cytoscape software,DAVID database,*** addition,the potential interaction and binding activity of candidate ingredients in Xuebijing injection with core targets were revealed by molecular docking simulation(Auto Dock software).Results:A total of 115 bioactive components in Xuebijing injection were collected,and416 targets including AKT1,TP53,VEGFA,ALB,TNF and so on were responsible for treating *** analysis revealed that matching core targets were closely associated with the inhibition of cytokine storm for its clinical beneficial effects in severe *** results of enrichment analysis indicated that PI3 K-Akt signaling pathway,human T-cell leukemia virus type 1 infection,mitogen-activated protein kinase signaling pathway,tuberculosis,focal adhesion,TNF signaling pathway,and small-cell lung cancer were represented pathways of Xuebijing injection against COVID-19 in terms of lung inflammation,virus infection,and lung ***,the active ingredients of Xuebijing injection exerted superior binding activities with 3 CLpro and ang

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