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Regulating the microenvironment with nanomaterials:Potential strategies to ameliorate COVID-19

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Acta Pharmaceutica Sinica B 2023年第9期13卷 3638-3658页

作者： Zhicheng Liu Zhuolei Han Xin Jin Jusung An Jaewon Kim Wenting Chen Jong Seung Kim Ji Zheng Jun Deng Department of Urology Xinqiao HospitalThird Military Medical University(Army Medical University)Chongqing 400037China Department of Urology Urological Surgery Research InstituteSouthwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Institute of Burn Research Southwest HospitalState Key Lab of TraumaBurn and Combined InjuryChongqing Key Laboratory for Disease ProteomicsThird Military Medical University(Army Medical University)Chongqing 400038China Tianjin Key Laboratory of Composite and Functional Materials School of Materials Science and EngineeringTianjin UniversityTianjin 300350China Department of Chemistry Korea UniversitySeoul 02841South Korea Department of Rheumatology and Clinical Immunology Army Medical CenterThird Military Medical University(Army Medical University)Chongqing 400042China

COVID-19,caused by SARS-CoV-2,has resulted in serious economic and health *** treatments remain inadequate to extinguish the epidemic,and efficient therapeutic approaches for COVID-19 are urgently being ***,accumulating evidence suggests that microenvironmental disorder plays an important role in the progression of COVID-19 in *** addition,recent advances in nanomaterial technologies provide promising opportunities for alleviating the altered homeostasis induced by a viral infection,providing new insight into COVID-19 *** literature reviews focus only on certain aspects of microenvironment alterations and fail to provide a comprehensive overview of the changes in homeostasis in COVID-19 *** fill this gap,this review systematically discusses alterations of homeostasis in COVID-19 patients and potential ***,advances in nanotechnology-based strategies for promoting homeostasis restoration are ***,we discuss the challenges and prospects of using nanomaterials for COVID-19 *** review provides a new strategy and insights into treating COVID-19 and other diseases associated with microenvironment disorders.

关键词： coronavirus disease 19 Severe acute respiratory syndrome coronavirus 2 Therapeutic approaches Nanotechnology Nanomaterial technologies Microenvironment Microenvironmental disorder Altered homeostasis

Global prevalence,mortality,and main risk factors for COVID-19 associated pneumocystosis:A systematic review and meta-analysis

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Asian Pacific Journal of Tropical Medicine 2022年第10期15卷 431-441页

作者： Hossein Khodadadi Ehsan Ahmadpour Sanam Nami Rasoul Mohammadi Hanieh Hosseini Mahsa Behravan Hamid Morovati Department of Parasitology and Mycology School of MedicineShiraz University of Medical SciencesShirazIran Drug Applied Research Center Tabriz University of Medical SciencesTabrizIran Department of Medical Mycology and Parasitology School of MedicineTabriz University of Medical SciencesTabrizIran Department of Medical Parasitology and Mycology School of MedicineIsfahan University of Medical SciencesIsfahanIran Immunology Research Center Tabriz University of Medical SciencesTabrizIran Student Research Committee Shiraz University of Medical SciencesShirazIran

Objective:Pneumocystis pneumonia(PcP)is a life-threatening infection caused by the opportunistic fungi Pneumocystis *** emergence of the COVID-19 pandemic forced the focus of attention of health policymakers on these two infections due to their clinical and paraclinical similarities,which cause diagnostic *** study was undertaken to evaluate and estimate the global prevalence and main leading risk factors of coronavirus-associated pneumocystosis(CAP).Methods:We searched related databases between December 2019 and May 2022 for studies reporting ***-analysis was performed using StatsDirect software(version 2.7.9)according to the DerSimonian and Laird method applying the random-effects *** evaluated heterogeneity using theχ2-based Q statistic(significant for P75%indicative of“notable”heterogeneity).Moreover,an odds ratio(OR)analysis was performed for eligible ***:Our meta-analysis included eight studies with 923 patients hospitalized with COVID-19;among them,92 were PcP *** overall pooled prevalence of CAP was estimated at 11.5%.The mortality among CAP patients was lower than that of non-PcP patients(OR 1.93;95%CI 0.86-4.31).Long-term corticosteroid therapy(OR 28.22;95%CI 0.54-1480.84)was the most predisposing factor for PcP among COVID-19 patients,followed by pulmonary diseases(OR 1.46;95%CI 0.43-4.98),kidney diseases(OR 1.26;95%CI 0.21-7.49),and acute respiratory destruction syndrome(OR 1.22;95%CI 0.05-29.28).Conclusions:The prevalence of PcP among the COVID-19 population is almost similar to the pre-COVID ***,PcP-related mortality was decreased by the emergence of the COVID-19 *** with COVID-19 are more susceptible to PcP than *** respiratory distress syndrome,kidney diseases,pulmonary diseases,and long-term corticosteroid therapy increased the risk of PcP;however,transplantation and malignancy decreased the risk for PcP among COVID-19 *** retrospective,cas

关键词： coronavirus disease 19 COVID-19 SARS-CoV-2 Pneumocystis pneumonia(PcP) COVID-associated infections Prevalence Odds ratio Risk factors

Recent Developments in SARS-CoV-2 Neutralizing Antibody Detection Methods

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Current Medical Science 2021年第6期41卷 1052-1064页

作者： Jo-Lewis BANGA NDZOUBOUKOU Yan-di ZHANG Xiong-lin FAN Department of Pathogen Biology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

The ongoing coronavirus disease 19 pandemic has likely changed the world in ways not seen in the *** antibody(NAb)assays play an important role in the management of the severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)*** these tools,we can assess the presence and duration of antibody-mediated protection in naturally infected individuals,screen convalescent plasma preparations for donation,test the efficacy of immunotherapy,and analyze NAb titers and persistence after vaccination to predict vaccine-induced protective *** review briefly summarizes the various methods used for the detection of SARS-CoV-2 NAbs and compares their advantages and disadvantages to facilitate their development and clinical application.

关键词： coronavirus disease 19 severe acute respiratory syndrome coronavirus-2 neutralizing antibodies viral neutralization test plaque reduction neutralization test pseudovirus-based neutralization assays enzyme-linked immunosorbent assay lateral flow immunoassays

Epidemiological and histopathological characteristics of thyroid carcinoma in a Tunisian health care center

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第1期10卷 37-42页

作者： Maissa Ben Thayer Fatma Khanchel Imen Helal Dorra Chiboub Hedhli Raoueh Ehsen Ben Brahim Raja Jouini Aschraf Chadli-Debbiche Faculty of Medicine of Tunis Tunis El Manar UniversityTunisTunisia Depatment of Pathology Habib Thameur's HospitalTunisTunisia Department of Otorhinolaryngology-Head and Neck surgery Habib Thameur's HospitalTunisTunisia

Background:Thyroid carcinoma(TC)accounts for almost 0.5%–1%of total *** incidence is increasing rapidly *** studies have drawn up the epidemiological profile of TC and its clinical and pathological ***,to date,no similar studies have been conducted in ***:To establish an epidemiological profile of TC in a Tunisian health care institute and to analyze its clinical and histopathological characteristics in our *** and Methods:We present a retrospective study reviewing the cases of TC diagnosed in our institution in a 4-year ***:We collected a sample of 192 cases of *** consisted of 31 males and 161 females(83.8%)with a sex-ratio M/F of *** mean age was 46.4 *** thyroid carcinoma was the most frequent histological *** multifocality rate was 33.8%.The mean size of TC was 2.2±1.9 cm.60.9%of TC were staged pT1 and 20.3%had nodal *** thyroid microcarcinomas were noted in 37.5%of ***:Our results were consistent with those of the literature.A high proportion of pT1 and pN0 tumors were noted in our series,suggesting that TC's diagnosis and management was performed at an early stage of the disease in our *** addition,our study enabled us to notice the impact of the coronavirus disease 19 crisis on the management of TC in our *** studies are needed to establish the epidemiological profile of TC in Tunisia and to assess its clinical and pathological features.

关键词： coronavirus disease 19 epidemiology papillary thyroid carcinoma papillary thyroid microcarcinoma pathology thyroid carcinoma

Potential and role of artificial intelligence in current medical healthcare

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Artificial Intelligence in Cancer 2022年第1期3卷 1-10页

作者： Chao-Ming Hung Hon-Yi Shi Po-Huang Lee Chao-Sung Chang Kun-Ming Rau Hui-Ming Lee Cheng-HaoTseng Sung-Nan Pei Kuen-Jang Tsai Chong-Chi Chiu Department of General Surgery E-Da Cancer HospitalKaohsiung 82445Taiwan College of Medicine I-Shou UniversityKaohsiung 82445Taiwan Department of Healthcare Administration and Medical Informatics Kaohsiung Medical UniversityKaohsiung 80708Taiwan Department of Business Management National Sun Yat-Sen UniversityKaohsiung 80420Taiwan Department of Medical Research Kaohsiung Medical University HospitalKaohsiung 80708Taiwan Department of Medical Research China Medical University HospitalChina Medical UniversityTaichung 40402Taiwan Department of Surgery E-Da HospitalKaohsiung 82445Taiwan Department of Hematology&Oncology E-Da Cancer HospitalKaohsiung 82445Taiwan School of Medicine for International Students College of MedicineI-Shou UniversityKaohsiung 82445Taiwan School of Medicine College of MedicineI-Shou UniversityKaohsiung 82445Taiwan Department of Gastroenterology and Hepatology E-Da Cancer HospitalKaohsiung 82445Taiwan Department of Gastroenterology and Hepatology E-Da HospitalKaohsiung 82445Taiwan Department of Medical Education and Research E-Da Cancer HospitalKaohsiung 82445Taiwan

Artificial intelligence(AI)is defined as the digital computer or computer-controlled robot's ability to mimic intelligent conduct and crucial thinking commonly associated with intelligent *** application of AI technology and machine learning in medicine have allowed medical practitioners to provide patients with better quality of services;and current advancements have led to a dramatic change in the healthcare ***,many efficient applications are still in their initial stages,which need further evaluations to improve and develop these *** must recognize and acclimate themselves with the developments in AI technology to improve their delivery of healthcare services;but for this to be possible,a significant revision of medical education is needed to provide future leaders with the required *** article reviews the potential and limitations of AI in healthcare,as well as the current medical application trends including healthcare administration,clinical decision assistance,patient health monitoring,healthcare resource allocation,medical research,and public health policy ***,future possibilities for further clinical and scientific practice were also summarized.

关键词： Artificial intelligence Machine learning Potential Limitation Medical healthcare application coronavirus disease 19