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Comparison of corneal biomechanics among primary open-angle glaucoma with normal tension or hypertension and controls

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Chinese Medical Journal 2021年第9期134卷 1087-1092页

作者： Ya-Hui Wei Yu Cai Bonnie N.K.Choy Bai-Bing Li Ruo-Shi Li Chen Xing Xia Wang Tian Tian Yuan Fang Mei Li Ying-Zi Pan Department of Ophthalmology Peking University First HospitalBeijing 100034China Department of Ophthalmology LKS Faculty of MedicineThe University of Hong KongHong KongChina Department of Ophthalmology Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China

Background:Normal tension glaucoma(NTG)is a less pressure-dependent type of glaucoma with characteristic optic ***,the biomechanical mechanism has been thought to account for glaucomatous optic neuropathy to some *** intended to compare dynamic corneal response parameters(DCRs)among patients with primary open-angle glaucoma with normal tension or hypertension and *** correlations between DCRs and known risk factors for glaucoma were also ***:In this cross-sectional study,49 NTG subjects,45 hypertension glaucoma(HTG)subjects,and 50 control subjects were *** compared the differences in DCRs using corneal visualization Scheimpflug technology among the NTG,HTG,and control *** also analyzed the correlations between DCRs and known risk factors for glaucoma(eg,central corneal thickness[CCT],intraocular pressure[IOP],etc).Results:The maximum inverse concave radius(NTG:0.18[0.17,0.20]mm-1;control:0.17[0.16,0.18]mm-1;P=0.033),deformation amplitude ratio of 2 mm(DAR 2 mm,NTG:4.87[4.33,5.39];control:4.37[4.07,4.88];P0.05).In the univariate and multivariate analyses,some of the DCRs,such as IR,were negatively correlated with CCT and IOP,whereas SP-A1 was positively correlated with CCT and ***:The cornea was more deformable in NTG than in HTG or *** were no significant differences in corneal deformability between HTG and *** cornea was more deformable with the thinner cornea and lower

关键词： corneal biomechanics Primary open-angle glaucoma Normal tension glaucoma Hypertensive glaucoma

Consideration of corneal biomechanics in the diagnosis and management of keratoconus: is it important?

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Eye and Vision 2016年第1期3卷 141-146页

作者： FangJun Bao Brendan Geraghty QinMei Wang Ahmed Elsheikh The Affiliated Eye Hospital of Wenzhou Medical University Wenzhou City 325027China The Institution of Ocular biomechanics Wenzhou Medical UniversityWenzhou City 325027China School of Engineering University of LiverpoolLiverpool City L693GHUK NIHR Biomedical Research Centre for Ophthalmology Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of OphthalmologyLondon CityUK

Keratoconus is a bilateral,non-inflammatory,degenerative corneal *** occurrence and development of keratoconus is associated with corneal thinning and conical protrusion,which causes irregular *** the disruption of the collagen organization,the cornea loses its shape and function resulting in progressive visual ***,corneal topography is the most important tool for the diagnosis of keratoconus,which may lead to false negatives among the patient population in the subclinical ***,it is now hypothesised that biomechanical destabilisation of the cornea may take place ahead of the topographic evidence of keratoconus,hence possibly assisting with disease diagnosis and *** article provides a review of the definition,diagnosis,and management strategies for keratoconus based on corneal biomechanics.

关键词： Keratoconus In vivo corneal biomechanics corneal collagen cross-linking

Changes in corneal biomechanics and intraocular pressure following Femto-LASIK using Goldman applanation tonometry and ocular response analyzer

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International Journal of Ophthalmology(English edition) 2020年第5期13卷 782-787页

作者： Ahmed Yassin Hemida Omar M Said Asser A.E.Abdel-Meguid Mohammed Iqbal Amani E Badawi Department of Ophthalmology Fayoum Ophthalmic HospitalFayoum 63514Egypt Department of Ophthalmology Faculty of MedicineFayoum UniversityFayoum 63514Egypt Department of Ophthalmology Faculty of MedicineCairo UniversityCairo 11562Egypt Department of Ophthalmology Faculty of MedicineSohag UniversitySohag 8242Egypt Department of Ophthalmology Faculty of MedicineMansoura UniversityMansoura 35516Egypt

AIM:To compare intraocular pressure(IOP)measurements before and after laser in situ keratomileusis(LASIK)with a femtosecond laser for flap creation using ocular response analyzer(ORA)and Goldmann applanation tonometry,and to identify factors that may influence the preoperative and postoperative ***:A prospective study conducted on myopic patients who underwent LASIK using a femtosecond laser for flap *** patients were evaluated preoperatively,6 wk and 3 mo postoperatively for manifest refraction(MR),keratometric(K)readings and central corneal thickness(CCT)using a scheimpflug-based *** resistance factor(CRF),corneal hysteresis(CH),Goldmann correlated IOP(IOPg)and corneal compensated IOP(IOPcc)were measured using ORA besides IOP assessment by Goldman applanation tonometry(GAT).RESULTS:There was a statistically significant decrease in measures of IOPg by 3.35±0.83 mm Hg,followed by GAT which decreased by 2.2±0.44 mm Hg,and the least affected by operation was IOPcc which decreased only by 0.87±0.1 mm Hg after 6 *** 3 mo follow up there was a statistically significant decrease in IOPcc which decreased only by 0.76±0.4 mm Hg,followed by IOP GAT by 1.6±0.5 mm Hg,and the most affected by operation was IOPg which decreased by 2.3±0.3 mm ***,there was a statistically significant decrease in CH and CRF after 6 wk and 3 *** 3 mo,the preoperative MR and preoperative GAT were prominent significant predictors of the postoperative GAT *** prediction equation was ***:IOP measurements and corneal biomechanical factors reduce significantly after LASIK with a femtosecond laser for flap *** IOPcc values are less influenced by changes in corneal properties than IOPg and GAT,indicating that IOPcc may provide the most reliable measurement of IOP after this procedure.

关键词： intraocular pressure laser in situ keratomileusis femtosecond laser ocular response analyzer corneal biomechanics myopia

Comparison of corneal biomechanics in Sjogren's syndrome and non-Sjogren's syndrome dry eyes by Scheimpflug based device

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International Journal of Ophthalmology(English edition) 2017年第5期10卷 711-716页

作者： Qin Long Jing-Yi Wang Dong Xu Ying Li Department of Ophthalmology Peking Union Medical College Hospital Chinese Academy of Medical Sciences &Peking Union Medical College Beijing 100730 China Department of Rheumatology and Clinical Immunology Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100730 China

AIM：To compare the corneal biomechanics of Sj？gren＇s syndrome（SS） and non-SS dry eyes with corneal Visualization Scheimpflug Technology（CorV is ST）.METHODS：corneal biomechanics and tear film parameters, namely the Schirmer I test value, tear film break-up time（TBUT） and corneal staining score（CSS） were detected in 34 eyes of 34 dry eye patients with SS（SSDE group） and 34 dry eye subjects without SS（NSSDE group） using CorV is ST. The differences of the above parameters between the two groups were examined, and the relationship between corneal biomechanics and tear film parameters were observed. RESULTS：The differences in age, sex, intraocular pressure（IOP） and central corneal thickness（CCT） were not significant between the two groups（P〉0.05）. The tear film parameters had significant differences between the SSDE group and NSSDE group（all P〈0.05）. Patients in the SSDE group had significantly lower A1-time and HC-time, but higher DA（P=0.01, 0.02, and 0.02, respectively） compared with the NSSDE group. In the SSDE group, DA was negatively correlated with TBUT（rho=-0.38, P=0.03）; HC-time was negatively correlated with CSS（rho=-0.43, P=0.02）. In the NSSDE group, HC-time was again negatively correlated with CSS（rho=-0.39, P=0.02）.CONCLUSION：There are differences in corneal biomechanical properties between SSDE and NSSDE. The cornea of SSDE tends to show less ＂stiffness＂, as seen by a significantly shorter A1-time and HC-time, but larger DA, compared with the cornea of NSSDE. Biomechanical parameters can be influenced by different tear film parameters in both groups.

关键词： corneal biomechanics Sjogren's syndrome dry eye

Review of in-vivo characterisation of corneal biomechanics

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Medicine in Novel Technology and Devices 2021年第3期11卷 34-39页

作者： Bernardo T.Lopes FangJun Bao JunJie Wang XiaoYu Liu LiZhen Wang Ahmed Abass Ashkan Eliasy Ahmed Elsheikh School of Engineering University of LiverpoolLiverpoolUK Department of Ophthalmology Federal Univerisity of Sao Paulo(UNIFESP)Sao PauloBrazil Eye Hospital Wenzhou Medical UniversityWenzhouChina The Institution of Ocular biomechanics Wenzhou Medical UniversityWenzhouChina Key Laboratory for biomechanics and Mechanobiology of Ministry of Education School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina Beijing Advanced Innovation Centre for Biomedical Engineering Beihang UniversityBeijingChina National Institute for Health Research(NIHR)Biomedical Research Centre for Ophthalmology Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of OphthalmologyLondonUK

The study of corneal biomechanics in vivo has been evolving fast in recent *** an organised corneal structure is necessary for its transparency,resistance to occasional external insults and bearing the intraocular pressure(IOP),which several clinically relevant events can *** review focuses on three techniques that are available for clinical use,namely the Ocular Response Analyzer(Reichert Ophthalmic Instruments,Buffalo,NY,USA),the Corvis ST(Oculus Optikgerate GmbH,Wetzlar,Germany)and the Brillouin Optical Scattering System(Intelon Optics Inc.,Lexington,MA,USA).The principles and the main parameters of each device are discussed along with their strategies to improve accuracy in the IOP measurement,corneal ectasia diagnosis,evaluation of corneal cross-linking procedures,and planning of corneal refractive surgeries.

关键词： corneal biomechanics corneal diagnosis Intraocular pressure corneal ectasia corneal cross linking

Review of ex-vivo characterisation of corneal biomechanics

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Medicine in Novel Technology and Devices 2021年第3期11卷 40-46页

作者： JunJie Wang XiaoYu Liu FangJun Bao Bernardo T.Lopes LiZhen Wang Ashkan Eliasy Ahmed Abass Ahmed Elsheikh Eye Hospital Wenzhou Medical UniversityWenzhouChina The Institution of Ocular biomechanics Wenzhou Medical UniversityWenzhouChina Key Laboratory for biomechanics and Mechanobiology of Ministry of Education School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina Beijing Advanced Innovation Centre for Biomedical Engineering Beihang UniversityBeijingChina School of Engineering University of LiverpoolLiverpoolUK Department of Ophthalmology Federal Univerisity of Sao Paulo(UNIFESP)Sao PauloBrazil National Institute for Health Research(NIHR)Biomedical Research Centre for Ophthalmology Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of OphthalmologyLondonUK

The evaluation of the corneal biomechanical behaviour has important clinical *** name a few,the accuracy of the intraocular pressure measurement,the study of corneal ectatic diseases and the assessment and optimisation of corneal surgical procedures are all highly influenced by corneal *** the last 45 years different ex-vivo methods were developed to study corneal biomechanical *** tissue maintenance,support,loading systems,as well as different monitoring strategies of corneal deformations were *** this review,the most important and commonly used methods are outlined,including strip extensiometry,inflation,compression,indentation and tissue separation *** particularities,applications,pros and cons and main applications are discussed.

关键词： Ex-vivo corneal biomechanics Experimental testing

Stromal lenticule addition keratoplasty with corneal crosslinking for corneal ectasia secondary to FS-LASIK:a case series

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 596-602页

作者： Li-Xiang Wang Ying-Ping Deng Meng-Zhen Xie Ke Ma Hong-Bo Yin Qiong Wang Rui Gong Jing Tang Department of Ophthalmology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina West China School of Medicine Sichuan UniversityChengdu 610041Sichuan ProvinceChina

●AIM:To explore the clinical efficacy and safety of stromal lenticule addition keratoplasty(SLAK)with corneal crosslinking(CXL)on patients with corneal ectasia secondary to femtosecond laser-assisted in situ keratomileusis(FS-LASIK).●METHODS:A series of 5 patients undertaking SLAK with CXL for the treatment of corneal ectasia secondary to FS-LASIK were followed for *** lenticules were collected from patients undertaking small incision lenticule extraction(SMILE)for the correction of *** a stromal lenticule was aimed at improving the corneal thickness for the safe application of crosslinking and compensating for the thin cornea to improve its mechanical strength.●RESULTS:All surgeries were conducted successfully with no significant *** best corrected visual acuity(BCVA)ranged from 0.05 to 0.8-2 before *** pre-operational total corneal thickness ranged from 345-404μm and maximum keratometry(Kmax)ranged from 50.8 to *** the combination surgery,both the corneal keratometry(range 55.9 to 92.8)and total corneal thickness(range 413-482μm)significantly *** out of 5 patients had improvement of corneal biomechanical parameters(reflected by stiffness parameter A1 in Corvis ST).However,3 patients showed decreased BCVA after surgery due to the development of irregular astigmatism and transient *** the onset of corneal edema right after SLAK,the corneal topography and thickness generally stabilized after 3mo.●CONCLUSION:SLAK with CXL is a potentially beneficial and safe therapy for advanced corneal *** work needs to address the poor predictability of corneal refractometry and compare the outcomes of different surgical modes.

关键词： corneal ectasia femtosecond laserassisted in situ keratomileusis stromal lenticule addition keratoplasty corneal crosslinking corneal thickness corneal biomechanics

Evaluation of corneal parameter changes under different accommodative stimuli with Scheimpflug imaging-based tomography

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国际眼科杂志 2024年第9期24卷 1357-1366页

作者： Farid J Bedrán-García David P Piñero Department of Optics Pharmacology and AnatomyUniversity of AlicanteAlicante 03690Spain

AIM:To evaluate the reliability of measurements of corneal changes with accommodation in healthy eyes using a Scheimpflug imaging-based system and how these measurements distribute in the normal ***:Prospective,non-randomized,comparative study including 27 healthy subjects(54 eyes),including emmetropia(13 eyes),myopia(17 eyes),hyperopia(4 eyes)and astigmatism(20 eyes)*** all cases,a complete eye examination was performed,including the analysis of corneal changes with different accommodative stimuli(+2.00,0.00 and-3.00 D)using the Pentacam AXL *** investigation was structured in 2 phases:repeatability analysis and characterization of accommodation-related corneal changes in healthy ***:In the repeatability analysis,the index of height asymmetry(IHA)showed the greatest variability with the three accommodative stimuli,being the results for the rest of parameters *** group of emmetropes showed significant differences with accommodative changes in the position of maximum keratometry(Kmax;Pcorneal thickness(MCT),corneal spherical aberration,and total and low order aberration root mean square(all Pcorneal changes between refractive ***,the consistency of the measurement

关键词： corneal biomechanics keratometry corneal thickness pachymetry corneal aberrations Pentacam accommodation

Short and long term corneal biomechanical analysis after overnight orthokeratology

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International Journal of Ophthalmology(English edition) 2022年第7期15卷 1128-1134页

作者： Amelia Nieto-Bona Paloma Porras-Ángel Adela Elena Ayllón-Gordillo Gonzalo Carracedo David P Piñero Department of Optometry&Vision Optics and Optometry FacultyComplutense University of MadridMadrid 28037Spain Department of Optics Pharmacology and AnatomyUniversity of AlicanteAlicante 03690Spain

AIM: To investigate the short and long term corneal biomechanical changes after overnight orthokeratology(OK) and compare them with those occurring in subjects not wearing contact ***: Retrospective case control study enrolling 54 subjects that were divided into three groups 18 subjects each: control group(CG), short term(15 nights) OK(STOK) group, and long term(more than 1 y of OK wear) OK(LTOK) group. corneal biomechanics were characterized using the Cor Vis? ST system(Oculus), recording parameters such as time [first/second applanation time(AT1, AT2)], speed [velocity of corneal apex at the first/second applanation time(AV1, AV2)], and amplitude of deformation(AD1, AD2) in the first and second corneal flattening, corneal stiffness(SPA1), biomechanically corrected intraocular pressure(b IOP) and corneal(CBI) and tomographic biomechanical indices(TBI).RESULTS: Significantly lower AD1 and standard deviate on of Ambrosio’s relational average thickness related to the horizontal profile(ARTh) values were found in the OK groups compared to CG(Pcorneal stif fness parameter(SPA1, P=0.97). Significant inverse correlations were found between corneal thickness and CBI in STOK(r=-0.90, Pcorneal biomechanical properties, but special care should be taken when analyzing biomechanical parameters influenced by corneal thickness such as amplitude of deformation, ARTh or CBI, because they change significantly after treatment but mainly due to the reduction and pachymetric progression induced by the corneal molding secondary to OK treatment.

关键词： overnight orthokeratology corneal biomechanics pachymetry corneal biomechanical index CorVis?ST tomographic biomechanical index